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VAD1 GRAM domain family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 839232, updated on 18-Sep-2024

Summary

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Official Symbol
VAD1
Official Full Name
GRAM domain family protein
Primary source
TAIR:AT1G02120
Locus tag
AT1G02120
See related
Araport:AT1G02120
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
T7I23.28; T7I23_28; VASCULAR ASSOCIATED DEATH1
Summary
Encodes VAD1 (Vascular Associated Death1), a regulator of cell death and defense responses in vascular tissues. VAD1 is a putative membrane associated protein and contains a GRAM domain. vad1 is a lesion mimic mutant that exhibits light conditional appearance of propagative HR (hypersensitive response)-like lesions along the vascular system.
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Genomic context

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See VAD1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
17
Sequence:
Chromosome: 1; NC_003070.9 (395689..400001)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Leucine carboxyl methyltransferase Neighboring gene bZIP domain class transcription factor (DUF630 and DUF632) Neighboring gene RAS 5 Neighboring gene ncRNA Neighboring gene miscRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An essential role for the VASt domain of the Arabidopsis VAD1 protein in the regulation of defense and cell death in response to pathogens. Khafif M, et al. PLoS One, 2017. PMID 28683084, Free PMC Article
  2. Ethylene is one of the key elements for cell death and defense response control in the Arabidopsis lesion mimic mutant vad1. Bouchez O, et al. Plant Physiol, 2007 Oct. PMID 17720753, Free PMC Article
  3. Vascular associated death1, a novel GRAM domain-containing protein, is a regulator of cell death and defense responses in vascular tissues. Lorrain S, et al. Plant Cell, 2004 Aug. PMID 15269331, Free PMC Article
  4. Putative glycosyltransferases and other plant Golgi apparatus proteins are revealed by LOPIT proteomics. Nikolovski N, et al. Plant Physiol, 2012 Oct. PMID 22923678, Free PMC Article
  5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. VAD1 acts as a negative regulator of cell death associated with the plant immune response and the VASt domain of this unknown protein plays an essential role in this function.
    Title: An essential role for the VASt domain of the Arabidopsis VAD1 protein in the regulation of defense and cell death in response to pathogens.
Submit: New GeneRIF Correction

General gene information

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NM_001331326.1
NM_100092.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to ethylene IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to salicylic acid IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in extracellular region HDA PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
GRAM domain family protein
NP_171714.2
  • VASCULAR ASSOCIATED DEATH1 (VAD1); INVOLVED IN: defense response to bacterium, negative regulation of programmed cell death; LOCATED IN: chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: GRAM (InterPro:IPR004182); BEST Arabidopsis thaliana protein match is: C2 domain-containing protein / GRAM domain-containing protein (TAIR:AT3G59660.1); Has 1155 Blast hits to 1034 proteins in 185 species: Archae - 0; Bacteria - 0; Metazoa - 619; Fungi - 222; Plants - 157; Viruses - 0; Other Eukaryotes - 157 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    395689..400001
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001331325.1 → NP_001321166.1  GRAM domain family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AQ22

  2. NM_100092.3 → NP_171714.2  GRAM domain family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_171714.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4HVW5
    UniProtKB/TrEMBL
    A0A178W223, A0A5S9S6A4, A0A654E7B3
    Conserved Domains (2) summary
    cd13220
    Location:80 → 173
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:275 → 424
    DUF4782; Domain of unknown function (DUF4782)

  3. NM_001331326.1 → NP_001321165.1  GRAM domain family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AQ01, Q8VZF8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F4HVW5.1

Gene LinkOut

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