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GAMMA-ADAPTIN 1 gamma-adaptin 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 839001, updated on 18-Sep-2024

Summary

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Official Symbol
GAMMA-ADAPTIN 1
Official Full Name
gamma-adaptin 1
Primary source
TAIR:AT1G23900
Locus tag
AT1G23900
See related
Araport:AT1G23900
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
Gamma-adaptin; gamma-adaptin 1; Gamma-ADR
Summary
Encodes large subunit of the heterotetrameric adaptor protein complex AP-1. AP-1 is required for clathrin coated vesicles budding from the trans-Golgi network or plasma membrane
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Genomic context

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See GAMMA-ADAPTIN 1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
18
Sequence:
Chromosome: 1; NC_003070.9 (8441073..8447681)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene trehalose-phosphatase/synthase 9 Neighboring gene NHL domain-containing protein Neighboring gene NHL domain-containing protein Neighboring gene Polyketide cyclase/dehydrase and lipid transport superfamily protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phylogenetic analysis of components of the eukaryotic vesicle transport system reveals a common origin of adaptor protein complexes 1, 2, and 3 and the F subcomplex of the coatomer COPI. Schledzewski K, et al. J Mol Evol, 1999 Jun. PMID 10229581
  2. Arabidopsis μ-adaptin subunit AP1M of adaptor protein complex 1 mediates late secretory and vacuolar traffic and is required for growth. Park M, et al. Proc Natl Acad Sci U S A, 2013 Jun 18. PMID 23733933, Free PMC Article
  3. Regulation of ADL6 activity by its associated molecular network. Lam BC, et al. Plant J, 2002 Sep. PMID 12207647
  4. Trans-Golgi network-located AP1 gamma adaptins mediate dileucine motif-directed vacuolar targeting in Arabidopsis. Wang X, et al. Plant Cell, 2014 Oct. PMID 25351491, Free PMC Article
  5. Arabidopsis EPSIN1 plays an important role in vacuolar trafficking of soluble cargo proteins in plant cells via interactions with clathrin, AP-1, VTI11, and VSR1. Song J, et al. Plant Cell, 2006 Sep. PMID 16905657, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_102238.2
NM_179370.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of AP-1 adaptor complex IEA
Inferred from Electronic Annotation
more info
  
part_of AP-1 adaptor complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
gamma-adaptin 1
NP_173802.1
  • gamma-adaptin 1 (GAMMA-ADAPTIN 1); FUNCTIONS IN: protein transporter activity, clathrin binding, binding; INVOLVED IN: vesicle-mediated transport; LOCATED IN: AP-1 adaptor complex; CONTAINS InterPro DOMAIN/s: Adaptor protein complex AP-1, gamma subunit (InterPro:IPR017107), Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain (InterPro:IPR008152), Armadillo-like helical (InterPro:IPR011989), Armadillo-type fold (InterPro:IPR016024), Clathrin adaptor, gamma-adaptin, appendage (InterPro:IPR008153), Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain (InterPro:IPR013041), Clathrin/coatomer adaptor, adaptin-like, N-terminal (InterPro:IPR002553); BEST Arabidopsis thaliana protein match is: Adaptor protein complex AP-1, gamma subunit (TAIR:AT1G60070.1); Has 3543 Blast hits to 3448 proteins in 308 species: Archae - 0; Bacteria - 4; Metazoa - 1517; Fungi - 967; Plants - 387; Viruses - 0; Other Eukaryotes - 668 (source: NCBI BLink).
NP_849701.1
  • gamma-adaptin 1 (GAMMA-ADAPTIN 1); FUNCTIONS IN: protein transporter activity, clathrin binding, binding; INVOLVED IN: vesicle-mediated transport; LOCATED IN: AP-1 adaptor complex; CONTAINS InterPro DOMAIN/s: Adaptor protein complex AP-1, gamma subunit (InterPro:IPR017107), Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain (InterPro:IPR008152), Armadillo-like helical (InterPro:IPR011989), Armadillo-type fold (InterPro:IPR016024), Clathrin adaptor, gamma-adaptin, appendage (InterPro:IPR008153), Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain (InterPro:IPR013041), Clathrin/coatomer adaptor, adaptin-like, N-terminal (InterPro:IPR002553); BEST Arabidopsis thaliana protein match is: Adaptor protein complex AP-1, gamma subunit (TAIR:AT1G60070.1); Has 3543 Blast hits to 3448 proteins in 308 species: Archae - 0; Bacteria - 4; Metazoa - 1517; Fungi - 967; Plants - 387; Viruses - 0; Other Eukaryotes - 668 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    8441073..8447681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001332624.1 → NP_001322140.1  gamma-adaptin 1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WHX1, A0A1P8AT76

  2. NM_179370.4 → NP_849701.1  gamma-adaptin 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_849701.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O81227, Q84K16, Q9LRA3, Q9XFS0
    UniProtKB/TrEMBL
    A0A178WHX1
    Conserved Domains (5) summary
    smart00809
    Location:763 → 873
    Alpha_adaptinC2; Adaptin C-terminal domain
    pfam01602
    Location:26 → 580
    Adaptin_N; Adaptin N terminal region
    pfam12717
    Location:317 → 450
    Cnd1; non-SMC mitotic condensation complex subunit 1
    pfam14796
    Location:718 → 801
    AP3B1_C; Clathrin-adaptor complex-3 beta-1 subunit C-terminal
    sd00044
    Location:314 → 338
    HEAT; HEAT repeat [structural motif]

  3. NM_102238.2 → NP_173802.1  gamma-adaptin 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_173802.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O81227, Q84K16, Q9LRA3, Q9XFS0
    UniProtKB/TrEMBL
    A0A178WHX1
    Conserved Domains (5) summary
    smart00809
    Location:763 → 873
    Alpha_adaptinC2; Adaptin C-terminal domain
    pfam01602
    Location:26 → 580
    Adaptin_N; Adaptin N terminal region
    pfam12717
    Location:317 → 450
    Cnd1; non-SMC mitotic condensation complex subunit 1
    pfam14796
    Location:718 → 801
    AP3B1_C; Clathrin-adaptor complex-3 beta-1 subunit C-terminal
    sd00044
    Location:314 → 338
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q84K16.1

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