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OGG1 8-oxoguanine-DNA glycosylase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 838775, updated on 18-Sep-2024

Summary

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Official Symbol
OGG1
Official Full Name
8-oxoguanine-DNA glycosylase 1
Primary source
TAIR:AT1G21710
Locus tag
AT1G21710
See related
Araport:AT1G21710
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
8-oxoguanine-DNA glycosylase 1; ARABIDOPSIS 8-OXOGUANINE-DNA GLYCOSYLASE 1; ATOGG1; F8K7.14; F8K7_14
Summary
Encodes 8-oxoguanine-DNA glycosylase. DNA repair enzyme.
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Genomic context

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See OGG1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
3
Sequence:
Chromosome: 1; NC_003070.9 (7624320..7626138)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene hydroxyproline-rich glycoprotein family protein Neighboring gene SWITCH/sucrose nonfermenting 3C Neighboring gene proteasome beta subunit C1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overexpression of AtOGG1, a DNA glycosylase/AP lyase, enhances seed longevity and abiotic stress tolerance in Arabidopsis. Chen H, et al. J Exp Bot, 2012 Jun. PMID 22473985
  2. Arabidopsis thaliana Ogg1 protein excises 8-hydroxyguanine and 2,6-diamino-4-hydroxy-5-formamidopyrimidine from oxidatively damaged DNA containing multiple lesions. Morales-Ruiz T, et al. Biochemistry, 2003 Mar 18. PMID 12627976
  3. Arabidopsis ZDP DNA 3'-phosphatase and ARP endonuclease function in 8-oxoG repair initiated by FPG and OGG1 DNA glycosylases. Córdoba-Cañero D, et al. Plant J, 2014 Sep. PMID 24934622
  4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Arabidopsis cells use both FPG and OGG1 to repair 8-oxoG in a pathway that requires ZDP and ARP in downstream steps.
    Title: Arabidopsis ZDP DNA 3'-phosphatase and ARP endonuclease function in 8-oxoG repair initiated by FPG and OGG1 DNA glycosylases.
  2. Overexpression of OGG1 enhances seed longevity and abiotic stress tolerance.
    Title: Overexpression of AtOGG1, a DNA glycosylase/AP lyase, enhances seed longevity and abiotic stress tolerance in Arabidopsis.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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NM_102020.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables damaged DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidized purine nucleobase lesion DNA N-glycosylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in base-excision repair IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
8-oxoguanine-DNA glycosylase 1
NP_173590.1
  • 8-oxoguanine-DNA glycosylase 1 (OGG1); FUNCTIONS IN: oxidized purine base lesion DNA N-glycosylase activity; INVOLVED IN: DNA repair, base-excision repair; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: DNA glycosylase (InterPro:IPR011257), Helix-hairpin-helix DNA-binding motif, class 1 (InterPro:IPR003583), Transcription factor TFIID, C-terminal/DNA glycosylase, N-terminal (InterPro:IPR012294), 8-oxoguanine DNA glycosylase, N-terminal (InterPro:IPR012904), HhH-GPD domain (InterPro:IPR003265); Has 951 Blast hits to 936 proteins in 417 species: Archae - 106; Bacteria - 332; Metazoa - 176; Fungi - 163; Plants - 46; Viruses - 0; Other Eukaryotes - 128 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    7624320..7626138
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_102020.4 → NP_173590.1  8-oxoguanine-DNA glycosylase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_173590.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FNY7, Q9XI06
    UniProtKB/TrEMBL
    A0A178WC14, A0A5S9VFB0
    Conserved Domains (1) summary
    TIGR00588
    Location:39 → 332
    ogg; 8-oxoguanine DNA-glycosylase (ogg)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FNY7.1

Gene LinkOut

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