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WAK1 cell wall-associated kinase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 838721, updated on 18-Sep-2024

Summary

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Official Symbol
WAK1
Official Full Name
cell wall-associated kinase
Primary source
TAIR:AT1G21250
Locus tag
AT1G21250
See related
Araport:AT1G21250
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtWAK1; cell wall-associated kinase; cell wall-associated kinase 1; F16F4.6; F16F4_6; PRO25; SERINE THREONINE KINASE
Summary
cell wall-associated kinase, may function as a signaling receptor of extracellular matrix component such as oligogalacturonides.
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Genomic context

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See WAK1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
3
Sequence:
Chromosome: 1; NC_003070.9 (7439171..7442113)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene wall associated kinase 3 Neighboring gene Protein kinase superfamily protein Neighboring gene pseudo Neighboring gene wall-associated kinase 2 Neighboring gene Copia-like polyprotein/retrotransposon

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A domain swap approach reveals a role of the plant wall-associated kinase 1 (WAK1) as a receptor of oligogalacturonides. Brutus A, et al. Proc Natl Acad Sci U S A, 2010 May 18. PMID 20439716, Free PMC Article
  2. In vitro characterization of the homogalacturonan-binding domain of the wall-associated kinase WAK1 using site-directed mutagenesis. Decreux A, et al. Phytochemistry, 2006 Jun. PMID 16631829
  3. Wall-associated kinase WAK1 interacts with cell wall pectins in a calcium-induced conformation. Decreux A, et al. Plant Cell Physiol, 2005 Feb. PMID 15769808
  4. WAKs: cell wall-associated kinases linking the cytoplasm to the extracellular matrix. Anderson CM, et al. Plant Mol Biol, 2001 Sep. PMID 11554472
  5. A cell wall-associated, receptor-like protein kinase. He ZH, et al. J Biol Chem, 1996 Aug 16. PMID 8702686

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a positive function of WAK1 and a negative function of GRP-3 and KAPP in the oligogalacturonides-triggered expression of defence genes and the production of an oxidative burst, is reported.
    Title: GRP-3 and KAPP, encoding interactors of WAK1, negatively affect defense responses induced by oligogalacturonides and local response to wounding.
  2. we also show that grp3-1 exhibits an enhanced Aluminum (Al) tolerance, a feature also described in AtWAK1 overexpressing plants. Together, these results implicate AtGRP3 function root size determination during development and in Al stress.
    Title: AtGRP3 Is Implicated in Root Size and Aluminum Response Pathways in Arabidopsis.
  3. The plant wall-associated kinase 1 (WAK1) functions as a oligogalacturonide receptor.
    Title: A domain swap approach reveals a role of the plant wall-associated kinase 1 (WAK1) as a receptor of oligogalacturonides.
  4. non-covalent link between WAK(67-254) and cell wall pectins is discussed in terms of cell elongation, cell differentiation and host-pathogen interactions
    Title: Wall-associated kinase WAK1 interacts with cell wall pectins in a calcium-induced conformation.
  5. Characterization of the homogalacturonan-binding domain of WAK1.
    Title: In vitro characterization of the homogalacturonan-binding domain of the wall-associated kinase WAK1 using site-directed mutagenesis.
  6. WAKs may thus provide a molecular mechanism linking cell wall sensing (via pectin attachment) to regulation of solute metabolism.
    Title: An Arabidopsis cell wall-associated kinase required for invertase activity and cell growth.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_101978.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables polysaccharide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell surface receptor signaling pathway IPI
Inferred from Physical Interaction
more info
 PubMed 
acts_upstream_of_or_within defense response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within response to salicylic acid IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to virus IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in plant-type cell wall IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plant-type vacuole HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
cell wall-associated kinase
NP_564137.1
  • cell wall-associated kinase (WAK1); FUNCTIONS IN: kinase activity; INVOLVED IN: cell surface receptor linked signaling pathway, response to virus, defense response to fungus, response to salicylic acid stimulus; LOCATED IN: plasma membrane, vacuole, plant-type cell wall; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: EGF-like calcium-binding (InterPro:IPR001881), EGF-like, type 3 (InterPro:IPR000742), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), EGF-like calcium-binding, conserved site (InterPro:IPR018097), EGF-type aspartate/asparagine hydroxylation site (InterPro:IPR000152), EGF calcium-binding (InterPro:IPR013091), EGF-like (InterPro:IPR006210); BEST Arabidopsis thaliana protein match is: wall associated kinase 3 (TAIR:AT1G21240.1); Has 130372 Blast hits to 120319 proteins in 4569 species: Archae - 123; Bacteria - 13482; Metazoa - 56283; Fungi - 9380; Plants - 33196; Viruses - 438; Other Eukaryotes - 17470 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    7439171..7442113
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_101978.5 → NP_564137.1  cell wall-associated kinase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_564137.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O81820, Q39191, Q56WT2, Q9LMP0
    UniProtKB/TrEMBL
    A0A5S9VDS8
    Conserved Domains (3) summary
    smart00179
    Location:282 → 323
    EGF_CA; Calcium-binding EGF-like domain
    cd14066
    Location:415 → 682
    STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs
    pfam13947
    Location:32 → 88
    GUB_WAK_bind; Wall-associated receptor kinase galacturonan-binding
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q39191.2

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