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RING/FYVE/PHD zinc finger superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 838600, updated on 18-Sep-2024

Summary

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Official Full Name
RING/FYVE/PHD zinc finger superfamily protein
Primary source
TAIR:AT1G20110
Locus tag
AT1G20110
See related
Araport:AT1G20110
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
FYVE-domain protein 1; FYVE1; T20H2.10; T20H2_10
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Genomic context

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Location:
chromosome: 1
Exon count:
10
Sequence:
Chromosome: 1; NC_003070.9 (6971424..6975130)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene RHO-related protein from plants 2 Neighboring gene DNA ligase-like protein Neighboring gene GDSL-like Lipase/Acylhydrolase superfamily protein Neighboring gene GDSL-like Lipase/Acylhydrolase superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The plant unique ESCRT component FREE1 regulates autophagosome closure. Zeng Y, et al. Nat Commun, 2023 Mar 30. PMID 36997511, Free PMC Article
  2. Autophagy Mediates the Degradation of Plant ESCRT Component FREE1 in Response to Iron Deficiency. Zhang T, et al. Int J Mol Sci, 2021 Aug 16. PMID 34445480, Free PMC Article
  3. The plant ESCRT component FREE1 shuttles to the nucleus to attenuate abscisic acid signalling. Li H, et al. Nat Plants, 2019 May. PMID 30962512
  4. Functional Analysis of Plant FYVE Domain Proteins in Endosomal Trafficking. Shen W, et al. Methods Mol Biol, 2020. PMID 32632807
  5. RST1 Is a FREE1 Suppressor That Negatively Regulates Vacuolar Trafficking in Arabidopsis. Zhao Q, et al. Plant Cell, 2019 Sep. PMID 31221737, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The plant unique ESCRT component FREE1 regulates autophagosome closure.
    Title: The plant unique ESCRT component FREE1 regulates autophagosome closure.
  2. Autophagy Mediates the Degradation of Plant ESCRT Component FREE1 in Response to Iron Deficiency.
    Title: Autophagy Mediates the Degradation of Plant ESCRT Component FREE1 in Response to Iron Deficiency.
  3. SINAT E3 Ubiquitin Ligases Mediate FREE1 and VPS23A Degradation to Modulate Abscisic Acid Signaling.
    Title: SINAT E3 Ubiquitin Ligases Mediate FREE1 and VPS23A Degradation to Modulate Abscisic Acid Signaling.
  4. Functional Analysis of Plant FYVE Domain Proteins in Endosomal Trafficking.
    Title: Functional Analysis of Plant FYVE Domain Proteins in Endosomal Trafficking.
  5. Analysis of Membrane Proteins Transport from Endosomal Compartments to Vacuoles.
    Title: Analysis of Membrane Proteins Transport from Endosomal Compartments to Vacuoles.
  6. The effect of ABRE BINDING FACTOR 4-mediated FYVE1 on salt stress tolerance in Arabidopsis.
    Title: The effect of ABRE BINDING FACTOR 4-mediated FYVE1 on salt stress tolerance in Arabidopsis.
  7. RST1 is a negative regulator controlling membrane protein homeostasis and FREE1-mediated functions in plants.
    Title: RST1 Is a FREE1 Suppressor That Negatively Regulates Vacuolar Trafficking in Arabidopsis.
  8. study demonstrates the crosstalk between endomembrane trafficking and ABA signalling at the transcriptional level and highlights the moonlighting properties of the plant ESCRT subunit FREE1, which has evolved unique non-endosomal functions in the nucleus besides its roles in membrane trafficking in the cytoplasm. [FREE1]
    Title: The plant ESCRT component FREE1 shuttles to the nucleus to attenuate abscisic acid signalling.
  9. FYVE1 is essential for plant growth and development and place FYVE1 as a key regulator of intracellular trafficking and vacuole biogenesis.
    Title: FYVE1 is essential for vacuole biogenesis and intracellular trafficking in Arabidopsis.
  10. FREE1 binds to phosphatidylinositol-3-phosphate (PI3P) and ubiquitin and specifically interacts with Vps23 via PTAP-like tetrapeptide motifs to be incorporated into the ESCRT-I complex.
    Title: A unique plant ESCRT component, FREE1, regulates multivesicular body protein sorting and plant growth.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_101865.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables mRNA binding HDA PubMed 
enables phosphatidylinositol binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within intralumenal vesicle formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multivesicular body assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of abscisic acid-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cellular response to alkaline pH IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of ESCRT I complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in late endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
RING/FYVE/PHD zinc finger superfamily protein
NP_564103.1
  • RING/FYVE/PHD zinc finger superfamily protein; FUNCTIONS IN: phosphoinositide binding; INVOLVED IN: signal transduction; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, FYVE-type (InterPro:IPR000306), Zinc finger, FYVE-related (InterPro:IPR017455), Zinc finger, FYVE/PHD-type (InterPro:IPR011011); BEST Arabidopsis thaliana protein match is: phosphatidylinositol-4-phosphate 5-kinase family protein (TAIR:AT3G14270.1); Has 29282 Blast hits to 20083 proteins in 828 species: Archae - 11; Bacteria - 1932; Metazoa - 10999; Fungi - 6486; Plants - 4104; Viruses - 590; Other Eukaryotes - 5160 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    6971424..6975130
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_101865.4 → NP_564103.1  RING/FYVE/PHD zinc finger superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_564103.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q940J6, Q9ASS2
    UniProtKB/TrEMBL
    A0A5S9V994, A0A654EBJ8
    Conserved Domains (2) summary
    smart00064
    Location:449 → 515
    FYVE; Protein present in Fab1, YOTB, Vac1, and EEA1
    cd00934
    Location:297 → 363
    PTB; Phosphotyrosine-binding (PTB) PH-like fold
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ASS2.1

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