FNR2 ferredoxin-NADP[+]-oxidoreductase 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: FNR2
Official Full Name: ferredoxin-NADP[+]-oxidoreductase 2
Primary source: TAIR:AT1G20020
Locus tag: AT1G20020
See related: Araport:AT1G20020
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATLFNR2; ferredoxin-NADP(+)-oxidoreductase 2; FERREDOXIN:NADP(H) OXIDOREDUCTASE; LEAF FNR 2; leaf-type chloroplast-targeted FNR 2; LFNR2; T20H2.20; T20H2_20
Summary: Encodes a leaf-type ferredoxin:NADP(H) oxidoreductase. It is present in both chloroplast stroma and thylakoid membranes but is more abundant in the stroma
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Genomic context

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See FNR2 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 9

Sequence:: Chromosome: 1; NC_003070.9 (6942625..6945091)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of photosynthetic electron flow on dark to light transition by ferredoxin:NADP(H) oxidoreductase interactions.
Title: Regulation of photosynthetic electron flow on dark to light transition by ferredoxin:NADP(H) oxidoreductase interactions.
The dynamic, multilayer regulation of AtFNR exemplifies the complex regulatory network systems controlling chloroplast proteins by a range of posttranslational modifications.
Title: Posttranslational modifications of FERREDOXIN-NADP+ OXIDOREDUCTASE in Arabidopsis chloroplasts.
FNR2 mutants have enhanced tolerance against oxidative stress and low temperatures.
Title: Comparative analysis of leaf-type ferredoxin-NADP oxidoreductase isoforms in Arabidopsis thaliana.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001084097.1

Supported by ESTs:

NM_001332422.1

Supported by ESTs:

NM_101857.6

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables NADPH dehydrogenase activity	IDA Inferred from Direct Assay more info
enables ferredoxin-NADP+ reductase activity	IEA Inferred from Electronic Annotation more info
enables poly(U) RNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to fungus	IDA Inferred from Direct Assay more info	PubMed
involved_in photosynthesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apoplast	HDA more info	PubMed
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast stroma	HDA more info	PubMed
located_in chloroplast stroma	IDA Inferred from Direct Assay more info
located_in chloroplast thylakoid	HDA more info	PubMed
located_in chloroplast thylakoid membrane	HDA more info	PubMed
located_in chloroplast thylakoid membrane	IDA Inferred from Direct Assay more info
part_of chloroplast thylakoid membrane protein complex	ISS Inferred from Sequence or Structural Similarity more info
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in thylakoid	HDA more info	PubMed

General protein information

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Preferred Names: ferredoxin-NADP[+]-oxidoreductase 2

NP_001077566.1

LEAF FNR 2 (ATLFNR2); FUNCTIONS IN: oxidoreductase activity, poly(U) RNA binding, NADPH dehydrogenase activity; INVOLVED IN: oxidation reduction, defense response to fungus, incompatible interaction, defense response to bacterium; LOCATED IN: thylakoid, chloroplast thylakoid membrane, apoplast, chloroplast stroma, chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Ferredoxin reductase-type FAD-binding domain (InterPro:IPR017927), Oxidoreductase, FAD-binding domain (InterPro:IPR008333), Ferredoxin--NADP reductase (InterPro:IPR012146), Oxidoreductase FAD/NAD(P)-binding (InterPro:IPR001433), Riboflavin synthase-like beta-barrel (InterPro:IPR017938), Ferredoxin Reductase (InterPro:IPR015701), Flavoprotein pyridine nucleotide cytochrome reductase (InterPro:IPR001709); BEST Arabidopsis thaliana protein match is: ferredoxin-NADP(+)-oxidoreductase 1 (TAIR:AT5G66190.1); Has 6779 Blast hits to 6779 proteins in 1702 species: Archae - 20; Bacteria - 3601; Metazoa - 804; Fungi - 729; Plants - 614; Viruses - 0; Other Eukaryotes - 1011 (source: NCBI BLink).

NP_001319047.1

LEAF FNR 2 (ATLFNR2); FUNCTIONS IN: oxidoreductase activity, poly(U) RNA binding, NADPH dehydrogenase activity; INVOLVED IN: oxidation reduction, defense response to fungus, incompatible interaction, defense response to bacterium; LOCATED IN: thylakoid, chloroplast thylakoid membrane, apoplast, chloroplast stroma, chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Oxidoreductase FAD/NAD(P)-binding (InterPro:IPR001433), Riboflavin synthase-like beta-barrel (InterPro:IPR017938), Ferredoxin Reductase (InterPro:IPR015701), Flavoprotein pyridine nucleotide cytochrome reductase (InterPro:IPR001709), Ferredoxin--NADP reductase (InterPro:IPR012146); BEST Arabidopsis thaliana protein match is: ferredoxin-NADP(+)-oxidoreductase 1 (TAIR:AT5G66190.1); Has 6542 Blast hits to 6542 proteins in 1635 species: Archae - 18; Bacteria - 3429; Metazoa - 796; Fungi - 693; Plants - 607; Viruses - 0; Other Eukaryotes - 999 (source: NCBI BLink).

NP_173431.1

ferredoxin-NADP(+)-oxidoreductase 2 (FNR2); FUNCTIONS IN: oxidoreductase activity, poly(U) RNA binding, NADPH dehydrogenase activity; INVOLVED IN: oxidation reduction, defense response to fungus, incompatible interaction, defense response to bacterium; LOCATED IN: thylakoid, chloroplast thylakoid membrane, apoplast, chloroplast stroma, chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Oxidoreductase FAD/NAD(P)-binding (InterPro:IPR001433), Ferredoxin reductase-type FAD-binding domain (InterPro:IPR017927), Oxidoreductase, FAD-binding domain (InterPro:IPR008333), Riboflavin synthase-like beta-barrel (InterPro:IPR017938), Ferredoxin Reductase (InterPro:IPR015701), Flavoprotein pyridine nucleotide cytochrome reductase (InterPro:IPR001709), Ferredoxin--NADP reductase (InterPro:IPR012146); BEST Arabidopsis thaliana protein match is: ferredoxin-NADP(+)-oxidoreductase 1 (TAIR:AT5G66190.1); Has 6774 Blast hits to 6774 proteins in 1708 species: Archae - 20; Bacteria - 3604; Metazoa - 802; Fungi - 759; Plants - 616; Viruses - 0; Other Eukaryotes - 973 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

6942625..6945091

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_101857.6 → NP_173431.1 ferredoxin-NADP[+]-oxidoreductase 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_173431.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A8MRF7, A8MRG5, Q8W493, Q9LNS9

UniProtKB/TrEMBL

A0A178WE91, A0A5S9VAW4

Conserved Domains (1) summary

PLN03115
Location:1 → 369

PLN03115; ferredoxin--NADP(+) reductase; Provisional
NM_001332422.1 → NP_001319047.1 ferredoxin-NADP[+]-oxidoreductase 2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

C0Z2A8
NM_001084097.1 → NP_001077566.1 ferredoxin-NADP[+]-oxidoreductase 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001077566.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8W493

Conserved Domains (2) summary

cd06208
Location:85 → 369

CYPOR_like_FNR; These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer ...

PLN03115
Location:1 → 369

PLN03115; ferredoxin--NADP(+) reductase; Provisional