MAML-4 methylthioalkylmalate synthase-like 4 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: MAML-4
Official Full Name: methylthioalkylmalate synthase-like 4
Primary source: TAIR:AT1G18500
Locus tag: AT1G18500
See related: Araport:AT1G18500
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F15H18.3; F15H18_3; IPMS1; ISOPROPYLMALATE SYNTHASE 1; methylthioalkylmalate synthase-like 4
Summary: Encodes an active Arabidopsis isopropylmalate synthase IPMS1. Involved in leucine biosynthesis. Do not participate in the chain elongation of glucosinolates. Expressed constitutively throughout the plant. Loss of IPMS1 can be compensated by a second isopropylmalate synthase gene IPMS2 (At1g74040).
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Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Two isopropylmalate synthase genes from A. thaliana are described.
Title: Two Arabidopsis genes (IPMS1 and IPMS2) encode isopropylmalate synthase, the branchpoint step in the biosynthesis of leucine.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_101708.3

Function	Evidence Code	Pubs
enables 2-isopropylmalate synthase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within L-leucine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in L-leucine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within L-leucine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast stroma	HDA more info	PubMed

NP_173285.2

methylthioalkylmalate synthase-like 4 (MAML-4); FUNCTIONS IN: 2-isopropylmalate synthase activity; INVOLVED IN: leucine biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), Alpha-isopropylmalate/homocitrate synthase, conserved site (InterPro:IPR002034), 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain (InterPro:IPR013709), Pyruvate carboxyltransferase (InterPro:IPR000891), Bacterial 2-isopropylmalate synthase (InterPro:IPR005671); BEST Arabidopsis thaliana protein match is: 2-isopropylmalate synthase 1 (TAIR:AT1G74040.1); Has 16947 Blast hits to 16939 proteins in 2437 species: Archae - 505; Bacteria - 8907; Metazoa - 233; Fungi - 482; Plants - 265; Viruses - 0; Other Eukaryotes - 6555 (source: NCBI BLink).