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EBS5 HCP-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 838406, updated on 18-Sep-2024

Summary

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Official Symbol
EBS5
Official Full Name
HCP-like superfamily protein
Primary source
TAIR:AT1G18260
Locus tag
AT1G18260
See related
Araport:AT1G18260
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
EMS-mutagenized bri1 suppressor 5; HRD3A; T10O22.22; T10O22_22
Summary
Encodes an Arabidopsis homolog of the yeast Hrd3/mammlian Sel1L protein. Involved in ERAD (Endoplasmic reticulum-associated degradation).
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Genomic context

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See EBS5 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
6
Sequence:
Chromosome: 1; NC_003070.9 (6278788..6282144, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Pathogenesis-related thaumatin superfamily protein Neighboring gene zein-binding protein (Protein of unknown function, DUF593) Neighboring gene ketose-bisphosphate aldolase class-II family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The endoplasmic reticulum-associated degradation is necessary for plant salt tolerance. Liu L, et al. Cell Res, 2011 Jun. PMID 21187857, Free PMC Article
  2. The Arabidopsis homolog of the mammalian OS-9 protein plays a key role in the endoplasmic reticulum-associated degradation of misfolded receptor-like kinases. Su W, et al. Mol Plant, 2012 Jul. PMID 22516478, Free PMC Article
  3. A context-independent N-glycan signal targets the misfolded extracellular domain of Arabidopsis STRUBBELIG to endoplasmic-reticulum-associated degradation. Hüttner S, et al. Biochem J, 2014 Dec 15. PMID 25251695, Free PMC Article
  4. Conserved endoplasmic reticulum-associated degradation system to eliminate mutated receptor-like kinases in Arabidopsis. Su W, et al. Proc Natl Acad Sci U S A, 2011 Jan 11. PMID 21187394, Free PMC Article
  5. EBS7 is a plant-specific component of a highly conserved endoplasmic reticulum-associated degradation system in Arabidopsis. Liu Y, et al. Proc Natl Acad Sci U S A, 2015 Sep 29. PMID 26371323, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_101684.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ERAD pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ERAD pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hyperosmotic salinity response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 

General protein information

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Preferred Names
HCP-like superfamily protein
NP_564049.1
  • HCP-like superfamily protein; FUNCTIONS IN: binding; INVOLVED IN: biological_process unknown; LOCATED IN: endoplasmic reticulum, membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide-like helical (InterPro:IPR011990), Sel1-like (InterPro:IPR006597); BEST Arabidopsis thaliana protein match is: HCP-like superfamily protein (TAIR:AT1G73570.1); Has 24350 Blast hits to 8436 proteins in 1359 species: Archae - 0; Bacteria - 17163; Metazoa - 848; Fungi - 960; Plants - 547; Viruses - 27; Other Eukaryotes - 4805 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    6278788..6282144 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_101684.4 → NP_564049.1  HCP-like superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_564049.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94BN9, Q9LM25
    UniProtKB/TrEMBL
    A0A5S9UZM5, A0A654ECV0
    Conserved Domains (4) summary
    smart00671
    Location:540 → 570
    SEL1; Sel1-like repeats
    COG0790
    Location:226 → 472
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:262 → 291
    SLR; SLR repeat [structural motif]
    pfam08238
    Location:279 → 313
    Sel1; Sel1 repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LM25.1

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