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GLYR2 glyoxylate reductase 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 838342, updated on 18-Sep-2024

Summary

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Official Symbol
GLYR2
Official Full Name
glyoxylate reductase 2
Primary source
TAIR:AT1G17650
Locus tag
AT1G17650
See related
Araport:AT1G17650
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtGLYR2; F11A6.12; glyoxylate reductase 2; GLYOXYLATE REDUCTASE 2; GR2
Summary
Glyoxylate reductase located in chloroplasts.
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Genomic context

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See GLYR2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
12
Sequence:
Chromosome: 1; NC_003070.9 (6069424..6072140, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Late embryogenesis abundant (LEA) hydroxyproline-rich glycoprotein family Neighboring gene Pentatricopeptide repeat (PPR-like) superfamily protein Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene CA-responsive protein Neighboring gene tRNA-Asp

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of catalytically important amino acid residues for enzymatic reduction of glyoxylate in plants. Hoover GJ, et al. Biochim Biophys Acta, 2013 Dec. PMID 24076009
  2. Identification and characterization of a plastid-localized Arabidopsis glyoxylate reductase isoform: comparison with a cytosolic isoform and implications for cellular redox homeostasis and aldehyde detoxification. Simpson JP, et al. J Exp Bot, 2008. PMID 18495639, Free PMC Article
  3. Gamma-hydroxybutyrate accumulation in Arabidopsis and tobacco plants is a general response to abiotic stress: putative regulation by redox balance and glyoxylate reductase isoforms. Allan WL, et al. J Exp Bot, 2008. PMID 18495640, Free PMC Article
  4. Quantitative proteomics of a chloroplast SRP54 sorting mutant and its genetic interactions with CLPC1 in Arabidopsis. Rutschow H, et al. Plant Physiol, 2008 Sep. PMID 18633119, Free PMC Article
  5. AT_CHLORO, a comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins. Ferro M, et al. Mol Cell Proteomics, 2010 Jun. PMID 20061580, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sequence and activity comparisons indicated that AtGLYR1 and AtGLYR2 possess structural features that are absent in Arabidopsis hydroxypyruvate reductases and probably account for their stronger preference for glyoxylate over hydroxypyruvate.
    Title: Identification of catalytically important amino acid residues for enzymatic reduction of glyoxylate in plants.
  2. GR1 and GR2 are involved in the regulation of Succinic semialdehyde detoxification in plants. [glyoxylate reductase 2] [AtGR2]
    Title: Gamma-hydroxybutyrate accumulation in Arabidopsis and tobacco plants is a general response to abiotic stress: putative regulation by redox balance and glyoxylate reductase isoforms.
  3. GR2 is glyoxylate reductase isoform that is localized to plastids. Kinetic studies revealed that the substrate preference for GR2 was similar to that reported for GR1. [GR2]
    Title: Identification and characterization of a plastid-localized Arabidopsis glyoxylate reductase isoform: comparison with a cytosolic isoform and implications for cellular redox homeostasis and aldehyde detoxification.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001332318.1
NM_101628.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables glyoxylate reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast stroma HDA PubMed 
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
glyoxylate reductase 2
NP_564030.2
  • glyoxylate reductase 2 (GLYR2); FUNCTIONS IN: phosphogluconate dehydrogenase (decarboxylating) activity, glyoxylate reductase (NADP) activity; INVOLVED IN: oxidation reduction, pentose-phosphate shunt, metabolic process; LOCATED IN: chloroplast stroma, chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: 6-phosphogluconate dehydrogenase, NAD-binding (InterPro:IPR006115), Dehydrogenase, multihelical (InterPro:IPR013328), 6-phosphogluconate dehydrogenase, C-terminal-like (InterPro:IPR008927), 3-hydroxyacid dehydrogenase/reductase (InterPro:IPR015815), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: glyoxylate reductase 1 (TAIR:AT3G25530.1); Has 16115 Blast hits to 16085 proteins in 2099 species: Archae - 147; Bacteria - 9815; Metazoa - 317; Fungi - 434; Plants - 311; Viruses - 1; Other Eukaryotes - 5090 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    6069424..6072140 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_101628.4 → NP_564030.2  glyoxylate reductase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_564030.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4I907, Q8RWF1
    UniProtKB/TrEMBL
    A0A178WM95, A0A5S9UV28, A0A654ELI4
    Conserved Domains (1) summary
    COG2084
    Location:68 → 351
    MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]

  2. NM_001332318.1 → NP_001321828.1  glyoxylate reductase 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AS42, A0A654ELI4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F4I907.1

Gene LinkOut

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