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Disease resistance protein (TIR-NBS-LRR class) family [ Arabidopsis thaliana (thale cress) ]

Gene ID: 838336, updated on 18-Sep-2024

Summary

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Official Full Name
Disease resistance protein (TIR-NBS-LRR class) family
Primary source
TAIR:AT1G17600
Locus tag
AT1G17600
See related
Araport:AT1G17600
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F1L3.30; F1L3_30
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Genomic context

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Location:
chromosome: 1
Exon count:
5
Sequence:
Chromosome: 1; NC_003070.9 (6052936..6058114, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene myosin 1 Neighboring gene nuclear factor Y, subunit A8 Neighboring gene Disease resistance protein (TIR-NBS class) Neighboring gene Disease resistance protein (TIR-NBS class) Neighboring gene Late embryogenesis abundant (LEA) hydroxyproline-rich glycoprotein family

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. E3 ligase SAUL1 serves as a positive regulator of PAMP-triggered immunity and its homeostasis is monitored by immune receptor SOC3. Tong M, et al. New Phytol, 2017 Sep. PMID 28691210
  2. Temperature-dependent autoimmunity mediated by chs1 requires its neighboring TNL gene SOC3. Zhang Y, et al. New Phytol, 2017 Feb. PMID 27699788
  3. TIR-NB-LRR immune receptor SOC3 pairs with truncated TIR-NB protein CHS1 or TN2 to monitor the homeostasis of E3 ligase SAUL1. Liang W, et al. New Phytol, 2019 Mar. PMID 30317650
  4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. By using CRISPR/Cas9 technology, genetic analysis and biochemical assays, it was discovered that SOC3 pairs with different truncated TN proteins, CHS1 or TN2, to monitor either the disappearance or overaccumulation of SAUL1, respectively. The differential pairing results in autoimmunity with distinct morphological outcomes. [SOC3]
    Title: TIR-NB-LRR immune receptor SOC3 pairs with truncated TIR-NB protein CHS1 or TN2 to monitor the homeostasis of E3 ligase SAUL1.
  2. the E3 ligase SAUL1 serves as a positive regulator of PAMP-triggered immunity and its homeostasis is monitored by the SOC3.[SOC3]
    Title: E3 ligase SAUL1 serves as a positive regulator of PAMP-triggered immunity and its homeostasis is monitored by immune receptor SOC3.
  3. This study reveals that the TN protein CHS1 interacts with the TNL protein SOC3 to modulate temperature-dependent autoimmunity.[SOC3]
    Title: Temperature-dependent autoimmunity mediated by chs1 requires its neighboring TNL gene SOC3.
Submit: New GeneRIF Correction

General gene information

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Homology

NM_101622.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ADP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of innate immune response IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Disease resistance protein (TIR-NBS-LRR class) family
NP_173203.2
  • Disease resistance protein (TIR-NBS-LRR class) family; FUNCTIONS IN: transmembrane receptor activity, ATP binding; INVOLVED IN: signal transduction, defense response, apoptosis, innate immune response; LOCATED IN: intrinsic to membrane; EXPRESSED IN: leaf whorl, leaf; EXPRESSED DURING: LP.10 ten leaves visible; CONTAINS InterPro DOMAIN/s: NB-ARC (InterPro:IPR002182), Toll-Interleukin receptor (InterPro:IPR000157), Disease resistance protein (InterPro:IPR000767); BEST Arabidopsis thaliana protein match is: Disease resistance protein (TIR-NBS-LRR class) family (TAIR:AT5G40100.1); Has 24331 Blast hits to 16604 proteins in 714 species: Archae - 19; Bacteria - 1452; Metazoa - 3934; Fungi - 232; Plants - 17994; Viruses - 0; Other Eukaryotes - 700 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    6052936..6058114 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_101622.3 → NP_173203.2  Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_173203.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WJH2, A0A5S9UWG8, F4I901
    Conserved Domains (2) summary
    PLN03210
    Location:1 → 976
    PLN03210; Resistant to P. syringae 6; Provisional
    sd00033
    Location:798 → 820
    LRR_RI; leucine-rich repeat [structural motif]
Nucleotide Protein
Heading Accession and Version

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