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SHA SH2 domain protein A [ Arabidopsis thaliana (thale cress) ]

Gene ID: 838274, updated on 18-Sep-2024

Summary

Official Symbol
SHA
Official Full Name
SH2 domain protein A
Primary source
TAIR:AT1G17040
Locus tag
AT1G17040
See related
Araport:AT1G17040
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS THALIANA SH2 DOMAIN PROTEIN A; ATSHA; F20D23.26; F20D23_26; SH2 domain protein A; STAT-TYPE LINKER-SH2 DOMAIN FACTOR A; STATLA
Summary
Encodes a protein that contains an SH2 domain. It can pull down a 120-kD tyrosine-phosphorylated protein in vitro. It is predicted to act as a transcription factor.
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Genomic context

See SHA in Genome Data Viewer
Location:
chromosome: 1
Exon count:
11
Sequence:
Chromosome: 1; NC_003070.9 (5824771..5828266)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene senescence-related gene 1 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene solanesyl diphosphate synthase 2 Neighboring gene uncharacterized protein Neighboring gene cytochrome p450 72c1

General gene information

NM_001198089.1
NM_101564.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
 

General protein information

Preferred Names
SH2 domain protein A
NP_001185018.1
  • SH2 domain protein A (SHA); FUNCTIONS IN: sequence-specific DNA binding transcription factor activity, signal transducer activity; INVOLVED IN: signal transduction, regulation of transcription, DNA-dependent; LOCATED IN: nucleus; EXPRESSED IN: 11 plant structures; EXPRESSED DURING: 4 anthesis, C globular stage, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: SH2 motif (InterPro:IPR000980), STAT transcription factor, core (InterPro:IPR001217), Concanavalin A-like lectin/glucanase (InterPro:IPR008985); BEST Arabidopsis thaliana protein match is: SH2 domain protein B (TAIR:AT1G78540.1).
NP_173147.2
  • SH2 domain protein A (SHA); FUNCTIONS IN: sequence-specific DNA binding transcription factor activity, signal transducer activity; INVOLVED IN: signal transduction, regulation of transcription, DNA-dependent; LOCATED IN: nucleus; EXPRESSED IN: 11 plant structures; EXPRESSED DURING: 4 anthesis, C globular stage, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: SH2 motif (InterPro:IPR000980), STAT transcription factor, core (InterPro:IPR001217), Concanavalin A-like lectin/glucanase (InterPro:IPR008985); BEST Arabidopsis thaliana protein match is: SH2 domain protein B (TAIR:AT1G78540.1); Has 341 Blast hits to 335 proteins in 60 species: Archae - 0; Bacteria - 0; Metazoa - 258; Fungi - 0; Plants - 45; Viruses - 0; Other Eukaryotes - 38 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    5824771..5828266
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001332274.1NP_001321275.1  SH2 domain protein A [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WKF6
  2. NM_101564.4NP_173147.2  SH2 domain protein A [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_173147.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A1P8AQE5, B5X561, F4I632, Q9SHG3
    UniProtKB/TrEMBL
    A0A178WKF6
    Conserved Domains (2) summary
    cd10338
    Location:536641
    SH2_SHA; Src homology 2 (SH2) domain found in SH2 adaptor proteins A (SHA) Signal transducers
    cl22861
    Location:20168
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  3. NM_001198089.1NP_001185018.1  SH2 domain protein A [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001185018.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WKF6
    Conserved Domains (2) summary
    cd10338
    Location:546651
    SH2_SHA; Src homology 2 (SH2) domain found in SH2 adaptor proteins A (SHA) Signal transducers
    cl22861
    Location:20178
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...