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SR45 arginine/serine-rich 45 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 838230, updated on 5-Jan-2025

Summary

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Official Symbol
SR45
Official Full Name
arginine/serine-rich 45
Primary source
TAIR:AT1G16610
Locus tag
AT1G16610
See related
Araport:AT1G16610
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
arginine/serine-rich 45; ARGININE/SERINE-RICH PROTEIN SR45; AtSR45; F19K19.9; F19K19_9; RNPS1
Summary
Encodes SR45, a member of the highly conserved family of serine/arginine-rich (SR) proteins, which play key roles in pre-mRNA splicing and other aspects of RNA metabolism. SR45 is a spliceosome protein, interacts with SR33 and the U1-70K protein of the U1 snRNP. Also involved in plant sugar response. sr45-1 mutation confers hypersensitivity to glucose during early seedling growth.
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Genomic context

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See SR45 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
12
Sequence:
Chromosome: 1; NC_003070.9 (5675495..5678873, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene DNA-binding HORMA family protein Neighboring gene miscRNA Neighboring gene pseudo Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ABA signaling prevents phosphodegradation of the SR45 splicing factor to alleviate inhibition of early seedling development in Arabidopsis. Albuquerque-Martins R, et al. Plant Commun, 2023 Mar 13. PMID 36419364, Free PMC Article
  2. The plant-specific SR45 protein negatively regulates glucose and ABA signaling during early seedling development in Arabidopsis. Carvalho RF, et al. Plant Physiol, 2010 Oct. PMID 20699397, Free PMC Article
  3. The Arabidopsis SR45 splicing factor bridges the splicing machinery and the exon-exon junction complex. Fanara S, et al. J Exp Bot, 2024 Apr 15. PMID 38180875
  4. The Arabidopsis splicing regulator SR45 confers salt tolerance in a splice isoform-dependent manner. Albaqami M, et al. Plant Mol Biol, 2019 Jul. PMID 30968308
  5. Transcriptome-Wide Identification of RNA Targets of Arabidopsis SERINE/ARGININE-RICH45 Uncovers the Unexpected Roles of This RNA Binding Protein in RNA Processing. Xing D, et al. Plant Cell, 2015 Dec. PMID 26603559, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Arabidopsis SR45 splicing factor bridges the splicing machinery and the exon-exon junction complex.
    Title: The Arabidopsis SR45 splicing factor bridges the splicing machinery and the exon-exon junction complex.
  2. The loss of SR45 results in enhanced sensitivity to salt stress and changes in expression and splicing of genes involved in regulating salt stress response.Only the long isoform (SR45.1) rescued the salt-sensitive phenotype as well as the altered gene expression and splicing patterns in the mutant.
    Title: The Arabidopsis splicing regulator SR45 confers salt tolerance in a splice isoform-dependent manner.
  3. Data demonstrate that SR45 regulates alternative splicing of the Arabidopsis 5PTase13 gene, which encodes an inositol polyphosphate 5-phosphatase previously shown to interact with and regulate the stability of SnRK1 in vitro, thus providing a mechanistic link between SR45 function and the modulation of degradation of the SnRK1 energy sensor in response to sugars.
    Title: The Arabidopsis SR45 Splicing Factor, a Negative Regulator of Sugar Signaling, Modulates SNF1-Related Protein Kinase 1 Stability.
  4. SR45 plays an unexpected role in mRNA processing of intronless genes, and numerous abscisic acid (ABA) signaling genes are targeted for regulation at the posttranscriptional level.
    Title: Transcriptome-Wide Identification of RNA Targets of Arabidopsis SERINE/ARGININE-RICH45 Uncovers the Unexpected Roles of This RNA Binding Protein in RNA Processing.
  5. SR45 recruits U1snRNP and U2AF to 5' and 3' splice sites, respectively, by interacting with pre-mRNA, U1-70K and U2AF(35) and modulates alternative splicing (AS).
    Title: Interactions of SR45, an SR-like protein, with spliceosomal proteins and an intronic sequence: insights into regulated splicing.
  6. Subcellular and subnuclear distribution of atSR45a and atSR30
    Title: Subcellular and subnuclear distribution of high-light responsive serine/arginine-rich proteins, atSR45a and atSR30, in Arabidopsis thaliana.
  7. DNA methylation establishment and maintenance defects present in sr45-1 mutants are enhanced in dcl3-1 mutant background, suggesting a synergistic cooperation between SR45 and DICER-LIKE3 (DCL3) in the RdDM pathway.
    Title: The splicing factor SR45 affects the RNA-directed DNA methylation pathway in Arabidopsis.
  8. SR45 is a negative regulator of sugar signaling during early seedling development and is involved in the repression of glucose-induced ABA accumulation and down-regulation of ABA biosynthesis
    Title: The plant-specific SR45 protein negatively regulates glucose and ABA signaling during early seedling development in Arabidopsis.
  9. The two alternatively spliced isoforms of SR$% have distinct biological functions.
    Title: Two alternatively spliced isoforms of the Arabidopsis SR45 protein have distinct roles during normal plant development.
  10. atSR45a proteins help to form the bridge between 5' and 3' splice sites in the spliceosome assembly.
    Title: Plant-specific SR-related protein atSR45a interacts with spliceosomal proteins in plant nucleus.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001198085.1
NM_001332238.1
NM_001332239.1
NM_001332240.1
NM_001332241.1
NM_101523.4
NM_202115.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within mRNA splicing, via spliceosome IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to abscisic acid IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sugar mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sugar mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
arginine/serine-rich 45
NP_001185014.1
  • arginine/serine-rich 45 (SR45); CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: arginine/serine-rich protein-related (TAIR:AT1G79100.1).
NP_173107.1
  • arginine/serine-rich 45 (SR45); FUNCTIONS IN: protein binding, RNA binding; INVOLVED IN: sugar mediated signaling pathway, nuclear mRNA splicing, via spliceosome, RNA splicing; LOCATED IN: nucleoplasm, nuclear speck, nucleolus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: arginine/serine-rich protein-related (TAIR:AT1G79100.1); Has 62425 Blast hits to 38843 proteins in 1486 species: Archae - 39; Bacteria - 6019; Metazoa - 27409; Fungi - 8585; Plants - 6560; Viruses - 1329; Other Eukaryotes - 12484 (source: NCBI BLink).
NP_973844.1
  • arginine/serine-rich 45 (SR45); FUNCTIONS IN: protein binding, RNA binding; INVOLVED IN: sugar mediated signaling pathway, nuclear mRNA splicing, via spliceosome, RNA splicing; LOCATED IN: nucleoplasm, nuclear speck, nucleolus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: arginine/serine-rich protein-related (TAIR:AT1G79100.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    5675495..5678873 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_202115.3 → NP_973844.1  arginine/serine-rich 45 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_973844.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178W7Y0, A0A5S9UQN2
    Conserved Domains (2) summary
    COG0724
    Location:96 → 199
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12365
    Location:100 → 172
    RRM_RNPS1; RNA recognition motif in RNA-binding protein with serine-rich domain 1 (RNPS1) and similar proteins

  2. NM_001332238.1 → NP_001321127.1  arginine/serine-rich 45 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8APW3

  3. NM_101523.4 → NP_173107.1  arginine/serine-rich 45 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_173107.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4I4H8, Q5E925, Q94AS1, Q9SEE9
    Conserved Domains (2) summary
    COG0724
    Location:96 → 199
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12365
    Location:100 → 172
    RRM_RNPS1; RNA recognition motif in RNA-binding protein with serine-rich domain 1 (RNPS1) and similar proteins

  4. NM_001332239.1 → NP_001321128.1  arginine/serine-rich 45 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8APZ4

  5. NM_001332241.1 → NP_001321126.1  arginine/serine-rich 45 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8APZ9

  6. NM_001332240.1 → NP_001321125.1  arginine/serine-rich 45 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8APZ9

  7. NM_001198085.1 → NP_001185014.1  arginine/serine-rich 45 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001185014.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178W7W5
    Conserved Domains (2) summary
    COG0724
    Location:96 → 199
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12365
    Location:100 → 172
    RRM_RNPS1; RNA recognition motif in RNA-binding protein with serine-rich domain 1 (RNPS1) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SEE9.1

Gene LinkOut

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