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PHR1 photolyase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 837792, updated on 18-Sep-2024

Summary

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Official Symbol
PHR1
Official Full Name
photolyase 1
Primary source
TAIR:AT1G12370
Locus tag
AT1G12370
See related
Araport:AT1G12370
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F5O11.9; F5O11_9; photolyase 1; TYPE II CPD PHOTOLYASE; UV RESISTANCE 2; UVR2
Summary
encodes an amino acid sequence with significant homology to the recently characterized type II photolyases. The uvr2-1 mutant is unable to remove CPDs in vivo, and plant extracts lack detectable photolyase activity, is sensitive to UV-B and is an allele
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Genomic context

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See PHR1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
9
Sequence:
Chromosome: 1; NC_003070.9 (4206360..4208999, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Cornichon family protein Neighboring gene 4-phospho-panto-thenoylcysteine synthetase Neighboring gene Sec1/munc18-like (SM) proteins superfamily Neighboring gene uncharacterized protein Neighboring gene Cornichon family protein Neighboring gene Nucleotide excision repair, TFIIH, subunit TTDA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. UVR2 ensures transgenerational genome stability under simulated natural UV-B in Arabidopsis thaliana. Willing EM, et al. Nat Commun, 2016 Dec 1. PMID 27905394, Free PMC Article
  2. Light-induced activation of class II cyclobutane pyrimidine dimer photolyases. Okafuji A, et al. DNA Repair (Amst), 2010 May 4. PMID 20227927
  3. Increased expression of the MYB-related transcription factor, PHR1, leads to enhanced phosphate uptake in Arabidopsis thaliana. Nilsson L, et al. Plant Cell Environ, 2007 Dec. PMID 17927693
  4. An enzyme similar to animal type II photolyases mediates photoreactivation in Arabidopsis. Ahmad M, et al. Plant Cell, 1997 Feb. PMID 9061951, Free PMC Article
  5. An Arabidopsis photolyase mutant is hypersensitive to ultraviolet-B radiation. Landry LG, et al. Proc Natl Acad Sci U S A, 1997 Jan 7. PMID 8990208, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. germline-specific UVR2 activity occurs during late flower development, and is important for ensuring low mutation rates in male and female cell lineages.
    Title: UVR2 ensures transgenerational genome stability under simulated natural UV-B in Arabidopsis thaliana.
  2. a different, but also effective, electron-transfer cascade is conserved among the class II photolyases
    Title: Light-induced activation of class II cyclobutane pyrimidine dimer photolyases.
  3. The phr1 knockout mutant has an altered phosphate allocation between root and shoot; accumulates less anthocyanins, sugars and starch than P-starved WT; has a lower AGPase activity; and is impaired in induction of a subset of Pi starvation-induced genes.
    Title: Increased expression of the MYB-related transcription factor, PHR1, leads to enhanced phosphate uptake in Arabidopsis thaliana.
Submit: New GeneRIF Correction

General gene information

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Homology

NM_001332032.1
NM_101109.1
NM_179320.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA photolyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables deoxyribodipyrimidine photo-lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within UV protection IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within photoreactive repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in plastid IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
photolyase 1
NP_563906.1
  • photolyase 1 (PHR1); CONTAINS InterPro DOMAIN/s: Rossmann-like alpha/beta/alpha sandwich fold (InterPro:IPR014729), DNA photolyase, N-terminal (InterPro:IPR006050), DNA photolyase, FAD-binding/Cryptochrome, C-terminal (InterPro:IPR005101), DNA photolyase, class 2 (InterPro:IPR008148); Has 1792 Blast hits to 1788 proteins in 474 species: Archae - 23; Bacteria - 644; Metazoa - 122; Fungi - 53; Plants - 107; Viruses - 39; Other Eukaryotes - 804 (source: NCBI BLink).
NP_849651.1
  • photolyase 1 (PHR1); CONTAINS InterPro DOMAIN/s: Rossmann-like alpha/beta/alpha sandwich fold (InterPro:IPR014729), DNA photolyase, N-terminal (InterPro:IPR006050), DNA photolyase, FAD-binding/Cryptochrome, C-terminal (InterPro:IPR005101), DNA photolyase, class 2 (InterPro:IPR008148); Has 2452 Blast hits to 2448 proteins in 660 species: Archae - 33; Bacteria - 979; Metazoa - 129; Fungi - 60; Plants - 123; Viruses - 39; Other Eukaryotes - 1089 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    4206360..4208999 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_179320.2 → NP_849651.1  photolyase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_849651.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O24374, Q94CC5, Q9LNA9, Q9SB00
    UniProtKB/TrEMBL
    A0A178WLR2, A0A5S9U2T1
    Conserved Domains (1) summary
    TIGR00591
    Location:5 → 467
    phr2; photolyase PhrII

  2. NM_001332032.1 → NP_001321694.1  photolyase 1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WLR2, A0A1P8ARP1

  3. NM_101109.1 → NP_563906.1  photolyase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_563906.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WLR2
    Conserved Domains (2) summary
    TIGR00591
    Location:5 → 461
    phr2; photolyase PhrII
    pfam00875
    Location:30 → 193
    DNA_photolyase; DNA photolyase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SB00.1

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