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fumarylacetoacetase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 837757, updated on 18-Sep-2024

Summary

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Official Full Name
fumarylacetoacetase
Primary source
TAIR:AT1G12050
Locus tag
AT1G12050
See related
Araport:AT1G12050
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtFAH; F12F1.8; F12F1_8; FAH; fumarylacetoacetate hydrolase; short-day sensitive cell deathshort-day sensitive cell deathshort-day sensitive cell death 111; SSCD1
Summary
Encodes a fumarylacetoacetase that converts fumarylacetoacetate to acetoacetate and fumarate and is likely to be involved in tyrosine catabolism.
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Genomic context

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Location:
chromosome: 1
Exon count:
15
Sequence:
Chromosome: 1; NC_003070.9 (4072741..4076207)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene leucine-rich repeat/extensin 1 Neighboring gene BCL-2-associated athanogene 5 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fumarylacetoacetate hydrolase is involved in salt stress response in Arabidopsis. Huang L, et al. Planta, 2018 Aug. PMID 29785518
  2. Disruption of fumarylacetoacetate hydrolase causes spontaneous cell death under short-day conditions in Arabidopsis. Han C, et al. Plant Physiol, 2013 Aug. PMID 23743712, Free PMC Article
  3. Enzymes of tyrosine catabolism in Arabidopsis thaliana. Dixon DP, et al. Plant Sci, 2006 Sep. PMID 22980205
  4. Profiling of the Receptor for Activated C Kinase 1a (RACK1a) interaction network in Arabidopsis thaliana. Guo J, et al. Biochem Biophys Res Commun, 2019 Dec 3. PMID 31606202
  5. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_101077.6

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables fumarylacetoacetase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-phenylalanine catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within homogentisate catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within tyrosine catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
located_in extracellular region HDA PubMed 

General protein information

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Preferred Names
fumarylacetoacetase
NP_172669.2
  • fumarylacetoacetase, putative; FUNCTIONS IN: fumarylacetoacetase activity, catalytic activity; INVOLVED IN: aromatic amino acid family metabolic process, metabolic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Fumarylacetoacetase, C-terminal-like (InterPro:IPR002529), Fumarylacetoacetase, C-terminal-related (InterPro:IPR011234), Fumarylacetoacetase, N-terminal (InterPro:IPR015377), Fumarylacetoacetase (InterPro:IPR005959); Has 4441 Blast hits to 4434 proteins in 1063 species: Archae - 139; Bacteria - 2814; Metazoa - 297; Fungi - 179; Plants - 60; Viruses - 0; Other Eukaryotes - 952 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    4072741..4076207
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_101077.6 → NP_172669.2  fumarylacetoacetase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_172669.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O65374, Q8RW90
    UniProtKB/TrEMBL
    A0A654EAN4
    Conserved Domains (1) summary
    PLN02856
    Location:1 → 421
    PLN02856; fumarylacetoacetase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8RW90.1

Gene LinkOut

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