cry4 cryptochrome circadian regulator 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cry4provided by ZNC
Official Full Name: cryptochrome circadian regulator 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-010426-7
See related: Ensembl:ENSDARG00000011890 AllianceGenome:ZFIN:ZDB-GENE-010426-7
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zcry4; fi23e01; wu:fi23e01
Summary: Enables photoreceptor activity. Predicted to be involved in circadian regulation of gene expression and entrainment of circadian clock by photoperiod. Located in cytoplasm. Is expressed in several structures, including brain; eye; heart; integument; and pleuroperitoneal region. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 22

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (819650..834106, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (802686..817212, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Analysis of zebrafish cryptochrome2 and 4 expression in UV cone photoreceptors.
Title: Analysis of zebrafish cryptochrome2 and 4 expression in UV cone photoreceptors.
Exposure of type 4 CRYs leads to the formation of two-electron-reduced FADH2 (or FADH-) without a detectable intermediate of FAD anion radical.
Title: Comparative photochemistry of animal type 1 and type 4 cryptochromes.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables FAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables photoreceptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in circadian regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in entrainment of circadian clock by photoperiod	IBA Inferred from Biological aspect of Ancestor more info
NOT acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cryptochrome circadian regulator 4

Names: cry3; cryptochrome 4; cryptochrome circadian clock 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131787.1 → NP_571862.1 cryptochrome circadian regulator 4

See identical proteins and their annotated locations for NP_571862.1

Status: PROVISIONAL

Source sequence(s)

AB042253

UniProtKB/TrEMBL

Q9I912

Conserved Domains (3) summary

COG0415
Location:5 → 485

PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]

pfam00875
Location:5 → 168

DNA_photolyase; DNA photolyase

pfam03441
Location:210 → 483

FAD_binding_7; FAD binding domain of DNA photolyase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007133.7 Reference GRCz11 Primary Assembly

Range

819650..834106 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068216375.1 → XP_068072476.1 cryptochrome circadian regulator 4 isoform X3
XM_009295766.4 → XP_009294041.1 cryptochrome circadian regulator 4 isoform X2

UniProtKB/TrEMBL

A0A8M3AMN1

Conserved Domains (3) summary

COG0415
Location:5 → 485

PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]

pfam00875
Location:5 → 168

DNA_photolyase; DNA photolyase

pfam03441
Location:210 → 483

FAD_binding_7; FAD binding domain of DNA photolyase
XM_005168277.5 → XP_005168334.1 cryptochrome circadian regulator 4 isoform X1

UniProtKB/TrEMBL

A0A8M2BFK9, F1R2R7

Related

ENSDARP00000096651.4, ENSDART00000105873.6

Conserved Domains (3) summary

COG0415
Location:26 → 506

PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]

pfam00875
Location:26 → 189

DNA_photolyase; DNA photolyase

pfam03441
Location:231 → 504

FAD_binding_7; FAD binding domain of DNA photolyase