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MLO4 Seven transmembrane MLO family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 837643, updated on 18-Sep-2024

Summary

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Official Symbol
MLO4
Official Full Name
Seven transmembrane MLO family protein
Primary source
TAIR:AT1G11000
Locus tag
AT1G11000
See related
Araport:AT1G11000
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATMLO4; MILDEW RESISTANCE LOCUS O 4; T19D16.26; T19D16_26
Summary
A member of a large family of seven-transmembrane domain proteins specific to plants, homologs of the barley mildew resistance locus o (MLO) protein. The Arabidopsis genome contains 15 genes encoding MLO proteins, with localization in plasma membrane. Phylogenetic analysis revealed four clades of closely-related AtMLO genes. ATMLO4 belongs to the clade I, with AtMLO11 and AtMLO14. The gene is expressed during early seedling growth, in roots and lateral root primordia, in flower and fruit abscission zone, in vascular system of root, cotyledons and young leaves, it was not expressed in mature rosette leaves, as shown by GUS activity patterns. The expression of several phylogenetically closely-related AtMLO genes showed similar or overlapping tissue specificity and analogous responsiveness to external stimuli, suggesting functional redundancy, co-function, or antagonistic function(s).
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Genomic context

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See MLO4 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
16
Sequence:
Chromosome: 1; NC_003070.9 (3671756..3676133, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Lung seven transmembrane receptor family protein Neighboring gene uncharacterized protein Neighboring gene tRNA-Met Neighboring gene RING/FYVE/PHD zinc finger superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Physiological characterization and genetic modifiers of aberrant root thigmomorphogenesis in mutants of Arabidopsis thaliana MILDEW LOCUS O genes. Bidzinski P, et al. Plant Cell Environ, 2014 Dec. PMID 24738718
  2. Two seven-transmembrane domain MILDEW RESISTANCE LOCUS O proteins cofunction in Arabidopsis root thigmomorphogenesis. Chen Z, et al. Plant Cell, 2009 Jul. PMID 19602625, Free PMC Article
  3. A membrane protein/signaling protein interaction network for Arabidopsis version AMPv2. Lalonde S, et al. Front Physiol, 2010. PMID 21423366, Free PMC Article
  4. Uncovering Arabidopsis membrane protein interactome enriched in transporters using mating-based split ubiquitin assays and classification models. Chen J, et al. Front Plant Sci, 2012. PMID 22737156, Free PMC Article
  5. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. mlo4/mlo11-conditioned root curling is not dependent upon light and endogenous flavonoids, but is pH-sensitive and affected by exogenous calcium levels.
    Title: Physiological characterization and genetic modifiers of aberrant root thigmomorphogenesis in mutants of Arabidopsis thaliana MILDEW LOCUS O genes.
  2. The results demonstrate that the exaggerated root curling phenotypes of the mlo4 and mlo11 mutants depend on auxin gradients and suggest that MLO4 and MLO11 cofunction as modulators of touch-induced root tropism.
    Title: Two seven-transmembrane domain MILDEW RESISTANCE LOCUS O proteins cofunction in Arabidopsis root thigmomorphogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001331947.1
NM_100975.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Seven transmembrane MLO family protein
NP_563882.1
  • MILDEW RESISTANCE LOCUS O 4 (MLO4); FUNCTIONS IN: calmodulin binding; INVOLVED IN: cell death, defense response; LOCATED IN: integral to membrane, plasma membrane; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: Mlo-related protein (InterPro:IPR004326); BEST Arabidopsis thaliana protein match is: Seven transmembrane MLO family protein (TAIR:AT5G53760.2); Has 528 Blast hits to 517 proteins in 50 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 522; Viruses - 0; Other Eukaryotes - 6 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    3671756..3676133 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001331948.1 → NP_001320916.1  Seven transmembrane MLO family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O23693, Q94KB8
    UniProtKB/TrEMBL
    A0A5S9TTS0, A0A654E9P2
    Conserved Domains (1) summary
    pfam03094
    Location:8 → 461
    Mlo; Mlo family

  2. NM_100975.3 → NP_563882.1  Seven transmembrane MLO family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_563882.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O23693, Q94KB8
    UniProtKB/TrEMBL
    A0A5S9TTS0, A0A654E9P2
    Conserved Domains (1) summary
    pfam03094
    Location:8 → 461
    Mlo; Mlo family

  3. NM_001331947.1 → NP_001320915.1  Seven transmembrane MLO family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8APG9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O23693.2

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