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SNRK2.4 Protein kinase superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 837637, updated on 18-Sep-2024

Summary

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Official Symbol
SNRK2.4
Official Full Name
Protein kinase superfamily protein
Primary source
TAIR:AT1G10940
Locus tag
AT1G10940
See related
Araport:AT1G10940
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS SERINE/THREONINE KINASE 1; ARABIDOPSIS SKP1 HOMOLOGUE 1; ASK1; SNF1-related protein kinase 2.4; SNRK2-4; SRK2A; SUCROSE NONFERMENTING 1-RELATED PROTEIN KINASE 2-4
Summary
Encodes a plant protein kinase similar to the calcium/calmodulin-dependent protein kinase subfamily and the SNF1 kinase subfamily (SnRK2) whose activity is activated by ionic (salt) and non-ionic (mannitol) osmotic stress. Kinase activity of its homolog in tobacco is induced by hyperosmotic condition within 1 minute.
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Genomic context

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See SNRK2.4 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
10
Sequence:
Chromosome: 1; NC_003070.9 (3655673..3658612, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Phosphatidylinositol-4-phosphate 5-kinase family protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene NB-ARC domain-containing disease resistance protein Neighboring gene DNA helicase (RECQl4A) Neighboring gene transmembrane nine 1 Neighboring gene ferredoxin 1 Neighboring gene zinc transporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and functional characterization of the Arabidopsis Snf1-related protein kinase SnRK2.4 phosphatidic acid-binding domain. Julkowska MM, et al. Plant Cell Environ, 2015 Mar. PMID 25074439
  2. SNF1-related protein kinases type 2 are involved in plant responses to cadmium stress. Kulik A, et al. Plant Physiol, 2012 Oct. PMID 22885934, Free PMC Article
  3. SNF1-Related Protein Kinases SnRK2.4 and SnRK2.10 Modulate ROS Homeostasis in Plant Response to Salt Stress. Szymańska KP, et al. Int J Mol Sci, 2019 Jan 2. PMID 30609769, Free PMC Article
  4. Phosphatase ABI1 and okadaic acid-sensitive phosphoprotein phosphatases inhibit salt stress-activated SnRK2.4 kinase. Krzywińska E, et al. BMC Plant Biol, 2016 Jun 13. PMID 27297076, Free PMC Article
  5. The Snf1-related protein kinases SnRK2.4 and SnRK2.10 are involved in maintenance of root system architecture during salt stress. McLoughlin F, et al. Plant J, 2012 Nov. PMID 22738204, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Arabidopsis sucrose non-fermenting-1-related protein kinase AtSnRK2.4 interacts with a transcription factor, AtMYB21, that is involved in salt tolerance.
    Title: The Arabidopsis sucrose non-fermenting-1-related protein kinase AtSnRK2.4 interacts with a transcription factor, AtMYB21, that is involved in salt tolerance.
  2. SNRK2.4 is involved in the regulation of ROS homeostasis in response to salinity.
    Title: SNF1-Related Protein Kinases SnRK2.4 and SnRK2.10 Modulate ROS Homeostasis in Plant Response to Salt Stress.
  3. Phosphatase ABI1 and okadaic acid-sensitive phosphatases of the PPP family are negative regulators of salt stress-activated SnRK2.4.
    Title: Phosphatase ABI1 and okadaic acid-sensitive phosphoprotein phosphatases inhibit salt stress-activated SnRK2.4 kinase.
  4. Biochemical characterization of the PA-SnRK2.4 interaction and shows that functionality of the SnRK2.4 primary PA-binding domain (PABD) affects root development.
    Title: Identification and functional characterization of the Arabidopsis Snf1-related protein kinase SnRK2.4 phosphatidic acid-binding domain.
  5. SnRK2.4 and -2.10 play a role in root growth and architecture in saline conditions.
    Title: The Snf1-related protein kinases SnRK2.4 and SnRK2.10 are involved in maintenance of root system architecture during salt stress.
  6. SnRK2.4 regulates level of reactive oxygen species produced in Arabidopsis roots in response to cadmium ions.
    Title: SNF1-related protein kinases type 2 are involved in plant responses to cadmium stress.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001035944.2
NM_100969.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within primary root development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to osmotic stress IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to osmotic stress IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to salt stress IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Protein kinase superfamily protein
NP_001031021.2
  • Protein kinase superfamily protein; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635), Serine/threonine-protein kinase-like, plant (InterPro:IPR015740); BEST Arabidopsis thaliana protein match is: SNF1-related protein kinase 2.10 (TAIR:AT1G60940.2).
NP_172563.1
  • SNF1-related protein kinase 2.4 (SNRK2.4); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636), Serine/threonine-protein kinase-like, plant (InterPro:IPR015740); BEST Arabidopsis thaliana protein match is: SNF1-related protein kinase 2.10 (TAIR:AT1G60940.2); Has 111412 Blast hits to 109617 proteins in 3021 species: Archae - 114; Bacteria - 12857; Metazoa - 41430; Fungi - 12032; Plants - 25317; Viruses - 521; Other Eukaryotes - 19141 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    3655673..3658612 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_100969.4 → NP_172563.1  Protein kinase superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_172563.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P43291
    UniProtKB/TrEMBL
    A0A178W429, A0A178W474, A0A5S9TQU3, A0A5S9WRD1
    Conserved Domains (1) summary
    cd14662
    Location:3 → 259
    STKc_SnRK2; Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 2

  2. NM_001035944.2 → NP_001031021.2  Protein kinase superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031021.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178W429, A0A5S9WRD1, F4I7B6
    Conserved Domains (2) summary
    smart00220
    Location:4 → 268
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14662
    Location:3 → 267
    STKc_SnRK2; Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43291.1

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