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ARR4 response regulator 4 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 837587, updated on 18-Sep-2024

Summary

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Official Symbol
ARR4
Official Full Name
response regulator 4
Primary source
TAIR:AT1G10470
Locus tag
AT1G10470
See related
Araport:AT1G10470
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATRR1; IBC7; INDUCED BY CYTOKININ 7; maternal effect embryo arrest 7; MEE7; RESPONCE REGULATOR 1; response regulator 4; T10O24.8; T10O24_8
Summary
Encodes a two-component response regulator. Acts redundantly with ARR3 in the control of circadian period in a cytokinin-independent manner.
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Genomic context

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See ARR4 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
5
Sequence:
Chromosome: 1; NC_003070.9 (3441988..3444360, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene B3 DNA-binding domain protein Neighboring gene germin-like protein 7 Neighboring gene zinc finger protein 5 Neighboring gene GNAT acetyltransferase (DUF699) Neighboring gene chloroplast-localized ISCA-like protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DEG9, a serine protease, modulates cytokinin and light signaling by regulating the level of ARABIDOPSIS RESPONSE REGULATOR 4. Chi W, et al. Proc Natl Acad Sci U S A, 2016 Jun 21. PMID 27274065, Free PMC Article
  2. EXO70D isoforms mediate selective autophagic degradation of type-A ARR proteins to regulate cytokinin sensitivity. Acheampong AK, et al. Proc Natl Acad Sci U S A, 2020 Oct 27. PMID 33051300, Free PMC Article
  3. Two genes with similarity to bacterial response regulators are rapidly and specifically induced by cytokinin in Arabidopsis. Brandstatter I, et al. Plant Cell, 1998 Jun. PMID 9634588, Free PMC Article
  4. Interaction of the response regulator ARR4 with phytochrome B in modulating red light signaling. Sweere U, et al. Science, 2001 Nov 2. PMID 11691995
  5. Stress-responsive expression of genes for two-component response regulator-like proteins in Arabidopsis thaliana. Urao T, et al. FEBS Lett, 1998 May 8. PMID 9607306

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EXO70D isoforms mediate selective autophagic degradation of type-A ARR proteins to regulate cytokinin sensitivity.
    Title: EXO70D isoforms mediate selective autophagic degradation of type-A ARR proteins to regulate cytokinin sensitivity.
  2. genetic evidence shows that DEG9 acts upstream of ARR4 and regulates the activity of ARR4 in cytokinin and light-signaling pathways
    Title: DEG9, a serine protease, modulates cytokinin and light signaling by regulating the level of ARABIDOPSIS RESPONSE REGULATOR 4.
  3. Mutating selected interface residues of ARR4 either abolished or destabilized the interaction. D45A and Y96A mutations weakened interaction with AHP1, and exhibited weaker rescue of root elongation in the hextuple mutants.
    Title: Destabilization of interaction between cytokinin signaling intermediates AHP1 and ARR4 modulates Arabidopsis development.
  4. Cross-talk between cytokinin and light signalling is mediated by ARR4.
    Title: Functional cross-talk between two-component and phytochrome B signal transduction in Arabidopsis.
  5. Results suggest that ARR3 and ARR4 are critical for proper circadian period and define an additional level of regulation of the circadian clock in Arabidopsis.
    Title: Arabidopsis response regulators ARR3 and ARR4 play cytokinin-independent roles in the control of circadian period.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001331908.1
NM_001331909.1
NM_100921.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables phosphorelay response regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables phosphorelay response regulator activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity HDA PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within circadian rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytokinin-activated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cytokinin-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cytokinin-activated signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within embryo development ending in seed dormancy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphorelay signal transduction system IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein autophosphorylation HDA PubMed 
acts_upstream_of_or_within red or far-red light signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within regulation of circadian rhythm IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to cytokinin IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to red light IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
response regulator 4
NP_172517.1
  • response regulator 4 (ARR4); CONTAINS InterPro DOMAIN/s: CheY-like (InterPro:IPR011006), Signal transduction response regulator, receiver domain (InterPro:IPR001789); BEST Arabidopsis thaliana protein match is: response regulator 3 (TAIR:AT1G59940.1); Has 56806 Blast hits to 56102 proteins in 2778 species: Archae - 292; Bacteria - 49762; Metazoa - 41; Fungi - 583; Plants - 1526; Viruses - 7; Other Eukaryotes - 4595 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    3441988..3444360 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_100921.3 → NP_172517.1  response regulator 4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_172517.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O82798
    UniProtKB/TrEMBL
    A0A178WJ74, A0A384KIL5, A0A7G2DRR3, Q2HIV3
    Conserved Domains (1) summary
    cd17581
    Location:36 → 157
    REC_typeA_ARR; phosphoacceptor receiver (REC) domain of type A Arabidopsis response regulators (ARRs) and similar proteins

  2. NM_001331909.1 → NP_001321924.1  response regulator 4 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8ASD9, A0A7G2DRR3

  3. NM_001331908.1 → NP_001321923.1  response regulator 4 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8ASI6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O82798.1

Gene LinkOut

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