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NAD(P)-binding Rossmann-fold superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 837570, updated on 18-Sep-2024

Summary

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Official Full Name
NAD(P)-binding Rossmann-fold superfamily protein
Primary source
TAIR:AT1G10310
Locus tag
AT1G10310
See related
Araport:AT1G10310
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F14N23.19; F14N23_19
Summary
encodes a NADPH-dependent pterin aldehyde reductase that accepts pterin aldehyde as well as dihydropterin aldehyde as substrates involved in metabolism and salvage of folate and its derivatives.
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Genomic context

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Location:
chromosome: 1
Exon count:
5
Sequence:
Chromosome: 1; NC_003070.9 (3381447..3384003, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene dynamin-like protein 6 Neighboring gene Nucleolar GTP-binding protein Neighboring gene Zinc finger C-x8-C-x5-C-x3-H type family protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Folate salvage in plants: pterin aldehyde reduction is mediated by multiple non-specific aldehyde reductases. Noiriel A, et al. Plant J, 2007 Aug. PMID 17550420
  2. Conserved and plant-specific histone acetyltransferase complexes cooperate to regulate gene transcription and plant development. Wu CJ, et al. Nat Plants, 2023 Mar. PMID 36879016
  3. Large-scale reverse genetics in Arabidopsis: case studies from the Chloroplast 2010 Project. Ajjawi I, et al. Plant Physiol, 2010 Feb. PMID 19906890, Free PMC Article
  4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutation of gene At1g10310 causes decreased seed 18:19 delta9 fatty acids.
    Title: Large-scale reverse genetics in Arabidopsis: case studies from the Chloroplast 2010 Project.
  2. typical of the generalist NADPH-linked reductases required for pterin aldehyde salvage in plants
    Title: Folate salvage in plants: pterin aldehyde reduction is mediated by multiple non-specific aldehyde reductases.
Submit: New GeneRIF Correction

General gene information

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NM_100905.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within folic acid-containing compound metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
NAD(P)-binding Rossmann-fold superfamily protein
NP_563866.1
  • NAD(P)-binding Rossmann-fold superfamily protein; CONTAINS InterPro DOMAIN/s: Short-chain dehydrogenase/reductase, conserved site (InterPro:IPR020904), NAD(P)-binding domain (InterPro:IPR016040), Glucose/ribitol dehydrogenase (InterPro:IPR002347), Short-chain dehydrogenase/reductase SDR (InterPro:IPR002198); BEST Arabidopsis thaliana protein match is: NAD(P)-binding Rossmann-fold superfamily protein (TAIR:AT3G55290.2); Has 116138 Blast hits to 115933 proteins in 3618 species: Archae - 897; Bacteria - 77623; Metazoa - 6898; Fungi - 5998; Plants - 2845; Viruses - 2; Other Eukaryotes - 21875 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    3381447..3384003 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_100905.4 → NP_563866.1  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_563866.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8LA87, Q9SY73
    UniProtKB/TrEMBL
    A0A178WMY3, A0A5S9TP45
    Conserved Domains (1) summary
    cd05233
    Location:20 → 205
    SDR_c; classical (c) SDRs
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SY73.1

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