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ECA3 endoplasmic reticulum-type calcium-transporting ATPase 3 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 837550, updated on 18-Sep-2024

Summary

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Official Symbol
ECA3
Official Full Name
endoplasmic reticulum-type calcium-transporting ATPase 3
Primary source
TAIR:AT1G10130
Locus tag
AT1G10130
See related
Araport:AT1G10130
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS THALIANA ER-TYPE CA2+-ATPASE 3; ATECA3; endoplasmic reticulum-type calcium-transporting ATPase 3; T27I1.16; T27I1_16
Summary
Encodes a golgi localized P2A-type Ca2+ ATPase involved in Mn nutrition and homeostasis.
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Genomic context

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See ECA3 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
34
Sequence:
Chromosome: 1; NC_003070.9 (3310930..3322269)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene F-box family protein Neighboring gene ncRNA Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene ncRNA Neighboring gene Uncharacterized conserved protein UCP031279 Neighboring gene Carbohydrate-binding protein Neighboring gene phloem protein 2-A10

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ECA3, a Golgi-localized P2A-type ATPase, plays a crucial role in manganese nutrition in Arabidopsis. Mills RF, et al. Plant Physiol, 2008 Jan. PMID 18024560, Free PMC Article
  2. A distinct endosomal Ca2+/Mn2+ pump affects root growth through the secretory process. Li X, et al. Plant Physiol, 2008 Aug. PMID 18567829, Free PMC Article
  3. Genomic comparison of P-type ATPase ion pumps in Arabidopsis and rice. Baxter I, et al. Plant Physiol, 2003 Jun. PMID 12805592, Free PMC Article
  4. Two additional type IIA Ca(2+)-ATPases are expressed in Arabidopsis thaliana: evidence that type IIA sub-groups exist. Pittman JK, et al. Gene, 1999 Aug 5. PMID 10433975
  5. Isolation and proteomic characterization of the Arabidopsis Golgi defines functional and novel components involved in plant cell wall biosynthesis. Parsons HT, et al. Plant Physiol, 2012 May. PMID 22430844, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AtECA3 supports Ca(2+)-stimulated root growth and the detoxification of high Mn(2+).
    Title: A distinct endosomal Ca2+/Mn2+ pump affects root growth through the secretory process.
  2. It was proposed that ECA3 is important for manganese and calcium homeostasis, possibly functioning in the transport of these ions into the Golgi.
    Title: ECA3, a Golgi-localized P2A-type ATPase, plays a crucial role in manganese nutrition in Arabidopsis.
Submit: New GeneRIF Correction

General gene information

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NM_100887.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ABC-type manganese transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables P-type calcium transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables P-type calcium transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within calcium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within manganese ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within manganese ion transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within root development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus HDA PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endomembrane system IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome HDA PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in trans-Golgi network HDA PubMed 

General protein information

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Preferred Names
endoplasmic reticulum-type calcium-transporting ATPase 3
NP_563860.1
  • endoplasmic reticulum-type calcium-transporting ATPase 3 (ECA3); FUNCTIONS IN: manganese-transporting ATPase activity, calcium-transporting ATPase activity, calmodulin binding; INVOLVED IN: manganese ion transport, calcium ion transport, root development, manganese ion homeostasis; LOCATED IN: endomembrane system, Golgi apparatus; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, P-type, ATPase-associated domain (InterPro:IPR008250), ATPase, P-type, calcium-transporting (InterPro:IPR005782), ATPase, P-type, H+ transporting proton pump (InterPro:IPR000695), ATPase, P-type cation-transporter, N-terminal (InterPro:IPR004014), Haloacid dehalogenase-like hydrolase (InterPro:IPR005834), ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (InterPro:IPR001757), ATPase, P-type phosphorylation site (InterPro:IPR018303), ATPase, P-type cation-transporter, C-terminal (InterPro:IPR006068); BEST Arabidopsis thaliana protein match is: endomembrane-type CA-ATPase 4 (TAIR:AT1G07670.1); Has 52019 Blast hits to 33942 proteins in 3233 species: Archae - 1100; Bacteria - 36533; Metazoa - 4334; Fungi - 2931; Plants - 2474; Viruses - 3; Other Eukaryotes - 4644 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    3310930..3322269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_100887.3 → NP_563860.1  endoplasmic reticulum-type calcium-transporting ATPase 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_563860.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0WP80, Q6DQH3, Q9SAV5, Q9SMX2, Q9SWS8, Q9SY55
    UniProtKB/TrEMBL
    A0A654E9M6
    Conserved Domains (1) summary
    cd02083
    Location:5 → 975
    P-type_ATPase_SERCA; sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SY55.3

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