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BON3 Calcium-dependent phospholipid-binding Copine family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 837408, updated on 18-Sep-2024

Summary

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Official Symbol
BON3
Official Full Name
Calcium-dependent phospholipid-binding Copine family protein
Primary source
TAIR:AT1G08860
Locus tag
AT1G08860
See related
Araport:AT1G08860
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
BONZAI 3; F7G19.25; F7G19_25
Summary
Encodes a copine-like protein, which is a member of a newly identified class of calcium-dependent, phospholipid binding proteins that are present in a wide range of organisms. Overexpression of this gene suppresses bon1-1 phenotypes. Double mutant analyses with bon1-1 suggest that BON1 and BON3 have overlapping functions in maintaining cellular homeostasis and inhibiting cell death.
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Genomic context

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See BON3 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
16
Sequence:
Chromosome: 1; NC_003070.9 (2841969..2846350)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene copper/zinc superoxide dismutase 1 Neighboring gene DNA replication helicase Neighboring gene Ribosomal L18p/L5e family protein Neighboring gene tRNA-Ala Neighboring gene Histone superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multiple R-like genes are negatively regulated by BON1 and BON3 in arabidopsis. Li Y, et al. Mol Plant Microbe Interact, 2009 Jul. PMID 19522566
  2. BON1 interacts with the protein kinases BIR1 and BAK1 in modulation of temperature-dependent plant growth and cell death in Arabidopsis. Wang Z, et al. Plant J, 2011 Sep. PMID 21623975
  3. Opposing Effects on Two Phases of Defense Responses from Concerted Actions of HEAT SHOCK COGNATE70 and BONZAI1 in Arabidopsis. Gou M, et al. Plant Physiol, 2015 Nov. PMID 26408532, Free PMC Article
  4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables calcium-dependent phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent phospholipid binding NAS
Non-traceable Author Statement
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular homeostasis NAS
Non-traceable Author Statement
more info
  
acts_upstream_of_or_within negative regulation of programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cellular defense response NAS
Non-traceable Author Statement
more info
  
acts_upstream_of_or_within stomatal closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Calcium-dependent phospholipid-binding Copine family protein
NP_172362.3
  • BONZAI 3 (BON3); FUNCTIONS IN: calcium-dependent phospholipid binding; INVOLVED IN: N-terminal protein myristoylation, cellular homeostasis, positive regulation of cellular defense response, negative regulation of cell death; EXPRESSED IN: sperm cell, male gametophyte, flower, pollen tube; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, 4 anthesis, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: C2 membrane targeting protein (InterPro:IPR018029), C2 calcium/lipid-binding domain, CaLB (InterPro:IPR008973), Copine (InterPro:IPR010734), C2 calcium-dependent membrane targeting (InterPro:IPR000008), von Willebrand factor, type A (InterPro:IPR002035); BEST Arabidopsis thaliana protein match is: DCD (Development and Cell Death) domain protein (TAIR:AT5G61910.4); Has 1559 Blast hits to 1479 proteins in 107 species: Archae - 0; Bacteria - 0; Metazoa - 903; Fungi - 12; Plants - 319; Viruses - 0; Other Eukaryotes - 325 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    2841969..2846350
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_100759.4 → NP_172362.3  Calcium-dependent phospholipid-binding Copine family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_172362.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O04042, Q1KS96, Q5XQC7
    UniProtKB/TrEMBL
    A0A178WMW0, A0A5S9TED8
    Conserved Domains (3) summary
    cd04047
    Location:197 → 302
    C2B_Copine; C2 domain second repeat in Copine
    cd04048
    Location:52 → 177
    C2A_Copine; C2 domain first repeat in Copine
    cd01459
    Location:312 → 567
    vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XQC7.1

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