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EDR1 Protein kinase superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 837393, updated on 18-Sep-2024

Summary

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Official Symbol
EDR1
Official Full Name
Protein kinase superfamily protein
Primary source
TAIR:AT1G08720
Locus tag
AT1G08720
See related
Araport:AT1G08720
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATEDR1; ENHANCED DISEASE RESISTANCE 1; F22O13.20; F22O13_20; MAPKK KINASE EDR1
Summary
enhanced disease resistance 1 (EDR1) confers resistance to powdery mildew disease caused by the fungus Erysiphe cichoracearum
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Genomic context

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See EDR1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
12
Sequence:
Chromosome: 1; NC_003070.9 (2773941..2779308)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Presenilin-1 Neighboring gene F-box family protein Neighboring gene Myosin family protein with Dil domain-containing protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. EDR1 associates with its homologs to synergistically regulate plant immunity in Arabidopsis. Zhong G, et al. Plant Sci, 2023 May. PMID 36737004
  2. Overexpression of a kinase-deficient form of the EDR1 gene enhances powdery mildew resistance and ethylene-induced senescence in Arabidopsis. Tang D, et al. Plant J, 2002 Dec. PMID 12492839
  3. Arabidopsis EDR1 Protein Kinase Regulates the Association of EDS1 and PAD4 to Inhibit Cell Death. Neubauer M, et al. Mol Plant Microbe Interact, 2020 Apr. PMID 31876224, Free PMC Article
  4. Mutations in the EDR1 Gene Alter the Response of Arabidopsis thaliana to Phytophthora infestans and the Bacterial PAMPs flg22 and elf18. Geissler K, et al. Mol Plant Microbe Interact, 2015 Feb. PMID 25353364
  5. Cloning, overexpression, purification and preliminary X-ray analysis of the protein kinase domain of enhanced disease resistance 1 (EDR1) from Arabidopsis thaliana. Kaljunen H, et al. Acta Crystallogr F Struct Biol Commun, 2014 Jul. PMID 25005098, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MITOGEN-ACTIVATED PROTEIN KINASE3 enhances disease resistance of edr1 mutants by phosphorylating MAPKKK5.
    Title: MITOGEN-ACTIVATED PROTEIN KINASE3 enhances disease resistance of edr1 mutants by phosphorylating MAPKKK5.
  2. EDR1 associates with its homologs to synergistically regulate plant immunity in Arabidopsis.
    Title: EDR1 associates with its homologs to synergistically regulate plant immunity in Arabidopsis.
  3. Plant defensin expression triggered by fungal pathogen invasion depends on EDR1 protein kinase and ORA59 transcription factor in Arabidopsis thaliana.
    Title: Plant defensin expression triggered by fungal pathogen invasion depends on EDR1 protein kinase and ORA59 transcription factor in Arabidopsis thaliana.
  4. EDR4 associates with CHC2 and modulates plant immunity by regulating the relocation of EDR1 in Arabidopsis.
    Title: ENHANCED DISEASE RESISTANCE4 associates with CLATHRIN HEAVY CHAIN2 and modulates plant immunity by regulating relocation of EDR1 in Arabidopsis.
  5. ATL1 is a positive regulator of programmed cell death and EDR1 negatively regulates ATL1 activity at the TGN/EE and thus controls stress responses initiated by ATL1-mediated ubiquitination events.
    Title: The Arabidopsis EDR1 protein kinase negatively regulates the ATL1 E3 ubiquitin ligase to suppress cell death.
  6. A natural edr1 mutant in the background of C24, was identified.
    Title: Natural loss-of-function mutation of EDR1 conferring resistance to tomato powdery mildew in Arabidopsis thaliana accession C24.
  7. It was concluded that EDR1 contributes to the defense response of A. thaliana against P. infestans; these data position EDR1 as a negative regulator in postinvasive nonhost resistance.
    Title: Mutations in the EDR1 Gene Alter the Response of Arabidopsis thaliana to Phytophthora infestans and the Bacterial PAMPs flg22 and elf18.
  8. A catalytically inactive form of the EDR1 kinase domain was successfully crystallized in the presence of the ATP analogue AMP-PNP.
    Title: Cloning, overexpression, purification and preliminary X-ray analysis of the protein kinase domain of enhanced disease resistance 1 (EDR1) from Arabidopsis thaliana.
  9. our data indicate that EDR1 physically associates with MKK4/MKK5 and negatively regulates the MAPK cascade to fine-tune plant innate immunity.
    Title: EDR1 physically interacts with MKK4/MKK5 and negatively regulates a MAP kinase cascade to modulate plant innate immunity.
  10. EDR1 functions as a positive regulator of non-host resistance independently of PEN2, and is critical for pathogen-induced expression of plant defensins.
    Title: Roles of EDR1 in non-host resistance of Arabidopsis.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_100745.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables MAP kinase kinase kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables MAP kinase kinase kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine/tyrosine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in defense response to oomycetes IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of abscisic acid-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of defense response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of salicylic acid mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to ethylene IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in response to ethylene NAS
Non-traceable Author Statement
more info
  
acts_upstream_of_or_within response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to water deprivation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
NOT located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network transport vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Protein kinase superfamily protein
NP_563824.1
  • ENHANCED DISEASE RESISTANCE 1 (EDR1); FUNCTIONS IN: protein serine/threonine/tyrosine kinase activity, MAP kinase kinase kinase activity, kinase activity; INVOLVED IN: in 7 processes; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: Protein kinase superfamily protein (TAIR:AT5G11850.1); Has 120792 Blast hits to 119043 proteins in 4682 species: Archae - 98; Bacteria - 12672; Metazoa - 46002; Fungi - 10646; Plants - 32815; Viruses - 475; Other Eukaryotes - 18084 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    2773941..2779308
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001331786.1 → NP_001322729.1  Protein kinase superfamily protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AUW3, B2BDB9

  2. NM_100745.2 → NP_563824.1  Protein kinase superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_563824.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FPR3, Q9FRR5
    UniProtKB/TrEMBL
    A0A5S9TD59, A0A654E983, B2BDA5, B2BDA6, B2BDB9, B2BDC2
    Conserved Domains (3) summary
    cd13999
    Location:675 → 921
    STKc_MAP3K-like; Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine/Threonine kinases
    pfam07714
    Location:669 → 921
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14381
    Location:129 → 327
    EDR1; Ethylene-responsive protein kinase Le-CTR1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FPR3.1

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