ARA-2 Ras-related small GTP-binding family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ARA-2
Official Full Name: Ras-related small GTP-binding family protein
Primary source: TAIR:AT1G06400
Locus tag: AT1G06400
See related: Araport:AT1G06400
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARA2; ARABIDOPSIS THALIANA RAB GTPASE HOMOLOG A1A; ATRAB11E; ATRABA1A; SMALL GTP-BINDING PROTEIN; T2D23.10; T2D23_10
Summary: small GTP-binding protein (ara-2)
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Genomic context

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See ARA-2 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 2

Sequence:: Chromosome: 1; NC_003070.9 (1950596..1952880, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Involved in determining the composition of the cell wall, particularly with respect to pectin content, possibly through regulating trafficking of pectin from the Golgi to the apoplast. [RABA1A]
Title: Null mutants of individual RABA genes impact the proportion of different cell wall components in stem tissue of Arabidopsis thaliana.
ARA2 is an essential component of a pathway that couples auxin signaling to plant growth and development.
Title: Altered ARA2 (RABA1a) expression in Arabidopsis reveals the involvement of a Rab/YPT family member in auxin-mediated responses.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_100520.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell wall biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to auxin	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Ras-related small GTP-binding family protein

NP_172128.1

ARA-2; FUNCTIONS IN: GTP binding; INVOLVED IN: protein transport, small GTPase mediated signal transduction; LOCATED IN: plasma membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Ras GTPase (InterPro:IPR001806), Small GTP-binding protein (InterPro:IPR005225), Small GTPase (InterPro:IPR020851), Ras (InterPro:IPR013753), Ras small GTPase, Rab type (InterPro:IPR003579), Rab11-related (InterPro:IPR015595); BEST Arabidopsis thaliana protein match is: RAB GTPase homolog A1C (TAIR:AT5G45750.1); Has 26542 Blast hits to 26487 proteins in 734 species: Archae - 28; Bacteria - 140; Metazoa - 13950; Fungi - 3642; Plants - 2996; Viruses - 20; Other Eukaryotes - 5766 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

1950596..1952880 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_100520.4 → NP_172128.1 Ras-related small GTP-binding family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_172128.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P28185

UniProtKB/TrEMBL

A0A178W910, A0A5S9SZA5

Conserved Domains (1) summary

cd01868
Location:11 → 175

Rab11_like; Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25