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Crispld1 cysteine-rich secretory protein LCCL domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 83691, updated on 27-Nov-2024

Summary

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Official Symbol
Crispld1provided by MGI
Official Full Name
cysteine-rich secretory protein LCCL domain containing 1provided by MGI
Primary source
MGI:MGI:1934666
See related
Ensembl:ENSMUSG00000025776 AllianceGenome:MGI:1934666
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lcrisp1; Cocoacrisp
Summary
Acts upstream of or within hematopoietic stem cell homeostasis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including axial skeleton; bone; meninges; nose; and respiratory system. Orthologous to human CRISPLD1 (cysteine rich secretory protein LCCL domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in limb E14.5 (RPKM 4.2), CNS E11.5 (RPKM 1.9) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Crispld1 in Genome Data Viewer
Location:
1 A3; 1 5.32 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (17797276..17840350)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (17727029..17767235)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00362 Neighboring gene STARR-seq mESC enhancer starr_00364 Neighboring gene predicted gene, 25166 Neighboring gene predicted gene 28154 Neighboring gene peptidase inhibitor 15 Neighboring gene STARR-seq mESC enhancer starr_00366 Neighboring gene predicted gene 16070 Neighboring gene STARR-seq mESC enhancer starr_00368 Neighboring gene high mobility group box transcription factor 1 pseudogene Neighboring gene NLR family, pyrin domain containing 4F pseudogene Neighboring gene centromere protein E pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A six-gene expression toolbox for the glands, epithelium and chondrocytes in the mouse nasal cavity. Wan Y, et al. Gene Expr Patterns, 2018 Jan. PMID 29122676
  2. Functional screen identifies regulators of murine hematopoietic stem cell repopulation. Holmfeldt P, et al. J Exp Med, 2016 Mar 7. PMID 26880577, Free PMC Article
  3. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in face morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in face morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hematopoietic stem cell homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cysteine-rich secretory protein LCCL domain-containing 1
Names
LCCL domain containing cysteine-rich secretory protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356551.2 → NP_001343480.1  cysteine-rich secretory protein LCCL domain-containing 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC104917, AC105075
    Consensus CDS
    CCDS35519.1
    UniProtKB/Swiss-Prot
    Q8CGD2, Q8K018, Q99MM6
    Related
    ENSMUSP00000124095.2, ENSMUST00000159958.8
    Conserved Domains (3) summary
    smart00603
    Location:291 → 375
    LCCL; LCCL domain
    cd18813
    Location:62 → 207
    CAP_CRISPLD1; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory protein LCCL domain-containing 1
    pfam03815
    Location:394 → 492
    LCCL; LCCL domain

  2. NM_001421149.1 → NP_001408078.1  cysteine-rich secretory protein LCCL domain-containing 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC104917, AC105075
    UniProtKB/Swiss-Prot
    Q8CGD2, Q8K018, Q99MM6

  3. NM_031402.3 → NP_113579.2  cysteine-rich secretory protein LCCL domain-containing 1 precursor

    See identical proteins and their annotated locations for NP_113579.2

    Status: VALIDATED

    Source sequence(s)
    AC104917, AC105075
    Consensus CDS
    CCDS35519.1
    UniProtKB/Swiss-Prot
    Q8CGD2, Q8K018, Q99MM6
    Related
    ENSMUSP00000092686.5, ENSMUST00000095075.5
    Conserved Domains (3) summary
    smart00603
    Location:291 → 375
    LCCL; LCCL domain
    cd18813
    Location:62 → 207
    CAP_CRISPLD1; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory protein LCCL domain-containing 1
    pfam03815
    Location:394 → 492
    LCCL; LCCL domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    17797276..17840350
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495594.5 → XP_006495657.1  cysteine-rich secretory protein LCCL domain-containing 1 isoform X2

    Conserved Domains (3) summary
    smart00603
    Location:190 → 274
    LCCL; LCCL domain
    pfam03815
    Location:293 → 391
    LCCL; LCCL domain
    cl00133
    Location:2 → 106
    CAP; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family

  2. XM_011238410.3 → XP_011236712.1  cysteine-rich secretory protein LCCL domain-containing 1 isoform X3

    Conserved Domains (2) summary
    smart00603
    Location:105 → 189
    LCCL; LCCL domain
    pfam03815
    Location:208 → 306
    LCCL; LCCL domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CGD2.1 GenPept UniProtKB/Swiss-Prot:Q8CGD2

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