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NRAMP4 natural resistance associated macrophage protein 4 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 836868, updated on 18-Sep-2024

Summary

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Official Symbol
NRAMP4
Official Full Name
natural resistance associated macrophage protein 4
Primary source
TAIR:AT5G67330
Locus tag
AT5G67330
See related
Araport:AT5G67330
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS THALIANA NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 4; ATNRAMP4; K8K14.5; K8K14_5; METAL TRANSPORTER NRAMP4; natural resistance associated macrophage protein 4
Summary
Encodes a member of the Nramp2 metal transporter family; like its homolog Atnramp3, localized in vacuolar membrane. Seedlings of double mutant, atnramp3-1 atnramp4-1, were arrested at early germination.
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Genomic context

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See NRAMP4 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
3
Sequence:
Chromosome: 5; NC_003076.8 (26861266..26863897)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene myb domain protein r1 Neighboring gene ncRNA Neighboring gene cytochrome P450, family 81, subfamily G, polypeptide 1 Neighboring gene WD-40 repeat family protein Neighboring gene ARM repeat superfamily protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Vacuolar Iron Stores Gated by NRAMP3 and NRAMP4 Are the Primary Source of Iron in Germinating Seeds. Bastow EL, et al. Plant Physiol, 2018 Jul. PMID 29784767, Free PMC Article
  2. Sorting of Arabidopsis NRAMP3 and NRAMP4 depends on adaptor protein complex AP4 and a dileucine-based motif. Müdsam C, et al. Traffic, 2018 Jul. PMID 29573093
  3. Bypassing Iron Storage in Endodermal Vacuoles Rescues the Iron Mobilization Defect in the natural resistance associated-macrophage protein3natural resistance associated-macrophage protein4 Double Mutant. Mary V, et al. Plant Physiol, 2015 Sep. PMID 26232490, Free PMC Article
  4. Export of vacuolar manganese by AtNRAMP3 and AtNRAMP4 is required for optimal photosynthesis and growth under manganese deficiency. Lanquar V, et al. Plant Physiol, 2010 Apr. PMID 20181755, Free PMC Article
  5. Mobilization of vacuolar iron by AtNRAMP3 and AtNRAMP4 is essential for seed germination on low iron. Lanquar V, et al. EMBO J, 2005 Dec 7. PMID 16270029, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NRAMP4 expression in the germinating seeds and its role in iron metabolism.
    Title: Vacuolar Iron Stores Gated by NRAMP3 and NRAMP4 Are the Primary Source of Iron in Germinating Seeds.
  2. Sorting of NRAMP4 depends on N-terminal dileucine-based motif and adaptor protein complex AP4.
    Title: Sorting of Arabidopsis NRAMP3 and NRAMP4 depends on adaptor protein complex AP4 and a dileucine-based motif.
  3. analysis of subcellular Fe localization indicates that simultaneous disruption of AtVIT1, AtNRAMP3, and AtNRAMP4 limits Fe accumulation in vacuolar globoids.
    Title: Bypassing Iron Storage in Endodermal Vacuoles Rescues the Iron Mobilization Defect in the natural resistance associated-macrophage protein3natural resistance associated-macrophage protein4 Double Mutant.
  4. The Cadmium (Cd) hypersensitivity of nramp3nramp4 mutant highlights the critical role of vacuolar metal stores to supply essential metals to plastids and maintain photosynthetic function under Cd and oxidative stresses.
    Title: Mutants impaired in vacuolar metal mobilization identify chloroplasts as a target for cadmium hypersensitivity in Arabidopsis thaliana.
  5. results presented here suggest an important role for AtNRAMP3/AtNRAMP4-dependent Mn transit through the vacuole prior to the import into chloroplasts of mesophyll cells
    Title: Export of vacuolar manganese by AtNRAMP3 and AtNRAMP4 is required for optimal photosynthesis and growth under manganese deficiency.
  6. AtNRAMP3 and AtNRAMP4 are involved in Arabidopsis thaliana resistance against the bacterial pathogen E. chrysanthemi.
    Title: NRAMP genes function in Arabidopsis thaliana resistance to Erwinia chrysanthemi infection.
  7. Mobilization of vacuolar iron (Fe) stores by AtNRAMP4 is crucial to support Arabidopsis early development until efficient systems for Fe acquisition from the soil take over.
    Title: Mobilization of vacuolar iron by AtNRAMP3 and AtNRAMP4 is essential for seed germination on low iron.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_126133.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables inorganic anion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables manganese ion transmembrane transporter activity TAS
Traceable Author Statement
more info
 PubMed 
enables metal ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion transmembrane transporter activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cadmium ion transport TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intracellular iron ion homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within intracellular monoatomic cation homeostasis NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within lead ion transport TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within manganese ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within manganese ion transport TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within metal ion transport TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of reactive oxygen species metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to iron ion IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to nematode HEP PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in plant-type vacuole HDA PubMed 
located_in plastid HDA PubMed 
located_in vacuolar membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vacuole HDA PubMed 

General protein information

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Preferred Names
natural resistance associated macrophage protein 4
NP_201534.1
  • natural resistance associated macrophage protein 4 (NRAMP4); FUNCTIONS IN: manganese ion transmembrane transporter activity, inorganic anion transmembrane transporter activity, metal ion transmembrane transporter activity; INVOLVED IN: in 11 processes; LOCATED IN: vacuolar membrane, vacuole; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Natural resistance-associated macrophage protein (InterPro:IPR001046); BEST Arabidopsis thaliana protein match is: natural resistance-associated macrophage protein 3 (TAIR:AT2G23150.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    26861266..26863897
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_126133.4 → NP_201534.1  natural resistance associated macrophage protein 4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_201534.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0WWH0, Q9FN18, Q9SNV8
    UniProtKB/TrEMBL
    A0A178UJ02, A0A5S9YI31
    Conserved Domains (1) summary
    cl00456
    Location:50 → 428
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FN18.1

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