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ALC basic helix-loop-helix (bHLH) DNA-binding superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 836846, updated on 18-Sep-2024

Summary

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Official Symbol
ALC
Official Full Name
basic helix-loop-helix (bHLH) DNA-binding superfamily protein
Primary source
TAIR:AT5G67110
Locus tag
AT5G67110
See related
Araport:AT5G67110
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ALCATRAZ; K21H1.7; K21H1_7
Summary
encodes a myc/bHLH transcription factor-like protein. Gene product is involved in fruit dehiscence. Mutant siliques fail to dehisce.
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Genomic context

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See ALC in Genome Data Viewer
Location:
chromosome: 5
Exon count:
5
Sequence:
Chromosome: 5; NC_003076.8 (26785106..26786431, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ralf-like 34 Neighboring gene mitogen-activated protein kinase kinase kinase 19 Neighboring gene Subtilisin-like serine endopeptidase family protein Neighboring gene DNA-directed DNA polymerase Neighboring gene RING/U-box superfamily protein Neighboring gene PLC-like phosphodiesterases superfamily protein Neighboring gene F-box/RNI-like superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Arabidopsis myc/bHLH gene ALCATRAZ enables cell separation in fruit dehiscence. Rajani S, et al. Curr Biol, 2001 Dec 11. PMID 11747817
  2. SPATULA and ALCATRAZ, are partially redundant, functionally diverging bHLH genes required for Arabidopsis gynoecium and fruit development. Groszmann M, et al. Plant J, 2011 Dec. PMID 21801252
  3. Novel nuclear protein ALC-INTERACTING PROTEIN1 is expressed in vascular and mesocarp cells in Arabidopsis. Wang F, et al. J Integr Plant Biol, 2008 Jul. PMID 18713402
  4. Conservation of fruit dehiscence pathways between Lepidium campestre and Arabidopsis thaliana sheds light on the regulation of INDEHISCENT. Lenser T, et al. Plant J, 2013 Nov. PMID 24004048
  5. Gibberellins control fruit patterning in Arabidopsis thaliana. Arnaud N, et al. Genes Dev, 2010 Oct 1. PMID 20889713, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Over-expression of ALCATRAZ can partially compensate for a loss of SPATULA function, and over-expression of SPATULA can fully compensate for loss of ALCATRAZ function.
    Title: SPATULA and ALCATRAZ, are partially redundant, functionally diverging bHLH genes required for Arabidopsis gynoecium and fruit development.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001085341.1
NM_001085342.1
NM_126111.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within fruit dehiscence IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
basic helix-loop-helix (bHLH) DNA-binding superfamily protein
NP_001078810.1
  • ALCATRAZ (ALC); CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: basic helix-loop-helix (bHLH) DNA-binding superfamily protein (TAIR:AT4G00050.1); Has 515 Blast hits to 509 proteins in 24 species: Archae - 0; Bacteria - 0; Metazoa - 1; Fungi - 0; Plants - 514; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).
NP_001078811.1
  • ALCATRAZ (ALC); CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: basic helix-loop-helix (bHLH) DNA-binding superfamily protein (TAIR:AT4G36930.1); Has 312 Blast hits to 312 proteins in 18 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 312; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).
NP_201512.1
  • ALCATRAZ (ALC); CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: basic helix-loop-helix (bHLH) DNA-binding superfamily protein (TAIR:AT4G36930.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    26785106..26786431 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_126111.4 → NP_201512.1  basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_201512.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8MRE6, A8MS60, Q9FHA2
    UniProtKB/TrEMBL
    A0A5S9YHR0, A0A654GEV2, Q680B1, Q8LFU9
    Conserved Domains (1) summary
    cd11445
    Location:94 → 156
    bHLH_AtPIF_like; basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana phytochrome interacting factors (PIFs) and similar proteins

  2. NM_001085342.1 → NP_001078811.1  basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001078811.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q680B1, Q8LFU9
    Conserved Domains (1) summary
    smart00353
    Location:91 → 126
    HLH; helix loop helix domain

  3. NM_001085341.1 → NP_001078810.1  basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001078810.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UQY8
    Conserved Domains (1) summary
    cd00083
    Location:98 → 137
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FHA2.1

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