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CIP8 COP1-interacting protein 8 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 836616, updated on 18-Sep-2024

Summary

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Official Symbol
CIP8
Official Full Name
COP1-interacting protein 8
Primary source
TAIR:AT5G64920
Locus tag
AT5G64920
See related
Araport:AT5G64920
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
COP1-interacting protein 8; COP1-INTERACTING PROTEIN CIP8; MXK3.15; MXK3_15
Summary
Encodes a RING-H2 protein that interacts with the RING finger domain of COP1. CIP8 exhibits a strong interaction with the E2 ubiquitin conjugating enzyme AtUBC8 through its N-terminal domain and promotes ubiquitination in an E2-dependent fashion in vitro. It is possible that the AtUBC8-CIP8 module might interact with COP1 in vivo, thereby participating in proteasome-mediated degradation of HY5.
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Genomic context

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See CIP8 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
1
Sequence:
Chromosome: 5; NC_003076.8 (25943888..25945442, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene precursor of peptide 1 Neighboring gene elicitor peptide 3 precursor Neighboring gene Serine/Threonine-kinase Neighboring gene ncRNA Neighboring gene CPR5 protein Neighboring gene ABC2 homolog 13

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The RING finger motif of photomorphogenic repressor COP1 specifically interacts with the RING-H2 motif of a novel Arabidopsis protein. Torii KU, et al. J Biol Chem, 1999 Sep 24. PMID 10488108
  2. LAF1 ubiquitination by COP1 controls photomorphogenesis and is stimulated by SPA1. Seo HS, et al. Nature, 2003 Jun 26. PMID 12827204
  3. Biochemical evidence for ubiquitin ligase activity of the Arabidopsis COP1 interacting protein 8 (CIP8). Hardtke CS, et al. Plant J, 2002 May. PMID 12028569
  4. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
  5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_125891.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
COP1-interacting protein 8
NP_201297.1
  • COP1-interacting protein 8 (CIP8); CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957); BEST Arabidopsis thaliana protein match is: RING/U-box superfamily protein (TAIR:AT5G01980.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    25943888..25945442 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_125891.3 → NP_201297.1  COP1-interacting protein 8 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_201297.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9SPL2
    UniProtKB/TrEMBL
    A0A178UJC6, A0A384L1Y1, A0A654GF77, A6XFC3
    Conserved Domains (3) summary
    cd00162
    Location:257 → 297
    RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]
    pfam14369
    Location:14 → 46
    zinc_ribbon_9; zinc-ribbon
    cl17238
    Location:257 → 298
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SPL2.1

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