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AOX2 alternative oxidase 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 836542, updated on 18-Sep-2024

Summary

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Official Symbol
AOX2
Official Full Name
alternative oxidase 2
Primary source
TAIR:AT5G64210
Locus tag
AT5G64210
See related
Araport:AT5G64210
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ALTERNATIVE OXIDASE; alternative oxidase 2; MSJ1.5; MSJ1_5
Summary
encodes an isoform of alternative oxidase, which is expressed in rosettes, stems, and roots. Transcript accumulates in dry seeds and decreased upon germination and is not affected by actinomycin A. Protein is localized to mitochondria.
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Genomic context

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See AOX2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
5
Sequence:
Chromosome: 5; NC_003076.8 (25683770..25685731, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene tropomyosin Neighboring gene neuronal PAS domain protein Neighboring gene serine/arginine-rich splicing factor-like protein, putative Neighboring gene Calmodulin-binding transcription activator protein with CG-1 and Ankyrin domain Neighboring gene 1,8-cineole synthase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The gene for alternative oxidase-2 (AOX2) from Arabidopsis thaliana consists of five exons unlike other AOX genes and is transcribed at an early stage during germination. Saish D, et al. Genes Genet Syst, 2001 Apr. PMID 11434463
  2. Alternative oxidases (AOX1a and AOX2) can functionally substitute for plastid terminal oxidase in Arabidopsis chloroplasts. Fu A, et al. Plant Cell, 2012 Apr. PMID 22534126, Free PMC Article
  3. The role of cyanoalanine synthase and alternative oxidase in promoting salt stress tolerance in Arabidopsis thaliana. Xu F, et al. BMC Plant Biol, 2023 Mar 27. PMID 36973660, Free PMC Article
  4. Functional Relationship of Arabidopsis AOXs and PTOX Revealed via Transgenic Analysis. Wang D, et al. Front Plant Sci, 2021. PMID 34367216, Free PMC Article
  5. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The role of cyanoalanine synthase and alternative oxidase in promoting salt stress tolerance in Arabidopsis thaliana.
    Title: The role of cyanoalanine synthase and alternative oxidase in promoting salt stress tolerance in Arabidopsis thaliana.
  2. The ability of AOX1a and AOX2 to substitute for PTOX in the correct physiological and developmental contexts is a striking example of the capacity of a mitochondrial protein to replace the function of a chloroplast protein.
    Title: Alternative oxidases (AOX1a and AOX2) can functionally substitute for plastid terminal oxidase in Arabidopsis chloroplasts.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables alternative oxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables superoxide-generating NADPH oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquinol:oxygen oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within alternative respiration ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
alternative oxidase 2
NP_201226.2
  • alternative oxidase 2 (AOX2); CONTAINS InterPro DOMAIN/s: Alternative oxidase (InterPro:IPR002680); BEST Arabidopsis thaliana protein match is: alternative oxidase 1A (TAIR:AT3G22370.1); Has 1305 Blast hits to 1305 proteins in 244 species: Archae - 0; Bacteria - 111; Metazoa - 12; Fungi - 191; Plants - 373; Viruses - 0; Other Eukaryotes - 618 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    25683770..25685731 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_125817.3 → NP_201226.2  alternative oxidase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_201226.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O22049, Q4PS98
    UniProtKB/TrEMBL
    A0A178UJF5, A0A5S9YGV6, A0A7G2FIP6
    Conserved Domains (1) summary
    PLN02478
    Location:19 → 353
    PLN02478; alternative oxidase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O22049.2

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