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TOP3A topoisomerase 3alpha [ Arabidopsis thaliana (thale cress) ]

Gene ID: 836513, updated on 18-Sep-2024

Summary

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Official Symbol
TOP3A
Official Full Name
topoisomerase 3alpha
Primary source
TAIR:AT5G63920
Locus tag
AT5G63920
See related
Araport:AT5G63920
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtTOP3alpha; MGI19.16; topoisomerase 3alpha
Summary
Encodes topoisomerase 3alpha. Suppresses somatic crossovers. Essential for resolution of meiotic recombination intermediates.
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Genomic context

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See TOP3A in Genome Data Viewer
Location:
chromosome: 5
Exon count:
24
Sequence:
Chromosome: 5; NC_003076.8 (25574419..25581433)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene farnesylcysteine lyase Neighboring gene Leucine-rich repeat protein kinase family protein Neighboring gene kinase with adenine nucleotide alpha hydrolases-like domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The topoisomerase 3α zinc-finger domain T1 of Arabidopsis thaliana is required for targeting the enzyme activity to Holliday junction-like DNA repair intermediates. Dorn A, et al. PLoS Genet, 2018 Sep. PMID 30222730, Free PMC Article
  2. Topoisomerase 3alpha and RMI1 suppress somatic crossovers and are essential for resolution of meiotic recombination intermediates in Arabidopsis thaliana. Hartung F, et al. PLoS Genet, 2008 Dec. PMID 19096507, Free PMC Article
  3. Multiple mechanisms limit meiotic crossovers: TOP3α and two BLM homologs antagonize crossovers in parallel to FANCM. Séguéla-Arnaud M, et al. Proc Natl Acad Sci U S A, 2015 Apr 14. PMID 25825745, Free PMC Article
  4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A. thaliana TOP3alpha conserved zinc-finger domain (ZFD) T1 is specifically required for targeting the topoisomerase activity to Holliday junction like recombination intermediates to enable their processing. In the case of an inactivated enzyme, this leads to cell death due to the masking of these intermediates, hindering their resolution by MUS81.
    Title: The topoisomerase 3α zinc-finger domain T1 of Arabidopsis thaliana is required for targeting the enzyme activity to Holliday junction-like DNA repair intermediates.
  2. Data indicate that both topoisomerase3alpha (TOP3alpha) and RECQ4A/B helicases act independently of the anti-meiotic crossovers (COs) Fanconi anemia of complementation group M (FANCM) helicase.
    Title: Multiple mechanisms limit meiotic crossovers: TOP3α and two BLM homologs antagonize crossovers in parallel to FANCM.
  3. AtTOP3alpha and AtRMI1 are involved in the suppression of crossover recombination in somatic cells and DNA repair.
    Title: Topoisomerase 3alpha and RMI1 suppress somatic crossovers and are essential for resolution of meiotic recombination intermediates in Arabidopsis thaliana.
Submit: New GeneRIF Correction

General gene information

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NM_125788.7

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA topoisomerase type I (single strand cut, ATP-independent) activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA topological change IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within resolution of meiotic recombination intermediates IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
topoisomerase 3alpha
NP_201197.1
  • topoisomerase 3alpha (TOP3A); FUNCTIONS IN: DNA topoisomerase activity, DNA topoisomerase type I activity, DNA binding, zinc ion binding, nucleic acid binding; INVOLVED IN: in 7 processes; LOCATED IN: chromosome; EXPRESSED IN: 17 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DNA topoisomerase, type IA, zn finger (InterPro:IPR013498), DNA topoisomerase, type IA, core (InterPro:IPR000380), DNA topoisomerase, type IA, domain 2 (InterPro:IPR003601), DNA topoisomerase, type IA, DNA-binding (InterPro:IPR003602), DNA topoisomerase, type IA, central (InterPro:IPR013497), Zinc finger, GRF-type (InterPro:IPR010666), DNA topoisomerase, type IA, central region, subdomain 3 (InterPro:IPR013826), Toprim domain, subgroup (InterPro:IPR006154), DNA topoisomerase, type IA, central region, subdomain 1 (InterPro:IPR013824), Toprim domain (InterPro:IPR006171), Zinc finger, CCHC-type (InterPro:IPR001878); BEST Arabidopsis thaliana protein match is: DNA topoisomerase, type IA, core (TAIR:AT2G32000.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    25574419..25581433
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_125788.7 → NP_201197.1  topoisomerase 3alpha [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_201197.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LVP1
    UniProtKB/TrEMBL
    A0A5S9YGZ2, A0A654GDT9
    Conserved Domains (2) summary
    PRK07219
    Location:10 → 702
    PRK07219; DNA topoisomerase I; Validated
    pfam06839
    Location:804 → 844
    zf-GRF; GRF zinc finger
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LVP1.1

Gene LinkOut

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