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FOLB2 Dihydroneopterin aldolase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 836418, updated on 18-Sep-2024

Summary

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Official Symbol
FOLB2
Official Full Name
Dihydroneopterin aldolase
Primary source
TAIR:AT5G62980
Locus tag
AT5G62980
See related
Araport:AT5G62980
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
MJH22.3; MJH22_3
Summary
Encodes an enzyme that can act as a aldolase or an epimerase for 7,8-dihydroneopterin and 7,8-dihydromonapterin in vitro. It is likely to act in folate biosynthesis as a homooctamer in vivo.
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Genomic context

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See FOLB2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
3
Sequence:
Chromosome: 5; NC_003076.8 (25276017..25277293)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ubiquitin carboxyl-terminal hydrolase family protein Neighboring gene miscRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Folate shapes plant root architecture by affecting auxin distribution. Li Y, et al. Plant J, 2023 Mar. PMID 36587293
  2. Folate biosynthesis in higher plants. cDNA cloning, heterologous expression, and characterization of dihydroneopterin aldolases. Goyer A, et al. Plant Physiol, 2004 May. PMID 15107504, Free PMC Article
  3. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

NM_125692.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables dihydroneopterin aldolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in folic acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intracellular auxin homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tetrahydrofolate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Dihydroneopterin aldolase
NP_201103.1
  • FOLB2; FUNCTIONS IN: dihydroneopterin aldolase activity; INVOLVED IN: folic acid and derivative metabolic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Dihydroneopterin aldolase (InterPro:IPR006157), Dihydroneopterin aldolase subgroup (InterPro:IPR006156); BEST Arabidopsis thaliana protein match is: Dihydroneopterin aldolase (TAIR:AT3G11750.1); Has 2737 Blast hits to 2737 proteins in 1212 species: Archae - 4; Bacteria - 2338; Metazoa - 0; Fungi - 0; Plants - 88; Viruses - 0; Other Eukaryotes - 307 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    25276017..25277293
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001345573.1 → NP_001332160.1  Dihydroneopterin aldolase [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FM54
    UniProtKB/TrEMBL
    A0A178U7H3, A0A5S9YGG6, A0A654GDJ6
    Conserved Domains (1) summary
    cd00534
    Location:10 → 126
    DHNA_DHNTPE; Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and ...

  2. NM_125692.4 → NP_201103.1  Dihydroneopterin aldolase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_201103.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FM54
    UniProtKB/TrEMBL
    A0A178U7H3, A0A5S9YGG6, A0A654GDJ6
    Conserved Domains (1) summary
    cd00534
    Location:10 → 126
    DHNA_DHNTPE; Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FM54.1

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