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Gmeb2 glucocorticoid modulatory element binding protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 83635, updated on 27-Nov-2024

Summary

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Official Symbol
Gmeb2provided by RGD
Official Full Name
glucocorticoid modulatory element binding protein 2provided by RGD
Primary source
RGD:620481
See related
EnsemblRapid:ENSRNOG00000013339 AllianceGenome:RGD:620481
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human GMEB2 (glucocorticoid modulatory element binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 62.5), Spleen (RPKM 56.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gmeb2 in Genome Data Viewer
Location:
3q43
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (188740210..188778377, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (168362650..168400788, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (176756006..176791960, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene fibronectin type III domain containing 11 Neighboring gene helicase with zinc finger 2 Neighboring gene uncharacterized LOC120101833 Neighboring gene regulator of telomere elongation helicase 1 Neighboring gene stathmin 3 Neighboring gene ARF related protein 1 Neighboring gene zinc finger CCCH-type and G-patch domain containing

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structure/activity relationships for GMEB-2: the second member of the glucocorticoid modulatory element-binding complex. Chen J, et al. Biochemistry, 2004 Jan 13. PMID 14705952
  2. Cloning and characterization of a novel binding factor (GMEB-2) of the glucocorticoid modulatory element. Zeng H, et al. J Biol Chem, 1998 Jul 10. PMID 9651376
  3. Genomic organization of human GMEB-1 and rat GMEB-2: structural conservation of two multifunctional proteins. Zeng H, et al. Nucleic Acids Res, 2000 Apr 15. PMID 10734202, Free PMC Article
  4. The factor binding to the glucocorticoid modulatory element of the tyrosine aminotransferase gene is a novel and ubiquitous heteromeric complex. Oshima H, et al. J Biol Chem, 1995 Sep 15. PMID 7665613
  5. Properties of the glucocorticoid modulatory element binding proteins GMEB-1 and -2: potential new modifiers of glucocorticoid receptor transactivation and members of the family of KDWK proteins. Kaul S, et al. Mol Endocrinol, 2000 Jul. PMID 10894151

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IC
Inferred by Curator
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glucocorticoid modulatory element-binding protein 2
Names
GMEB-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001389211.1 → NP_001376140.1  glucocorticoid modulatory element-binding protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6KM28
    Related
    ENSRNOP00000085762.2, ENSRNOT00000101387.2
    Conserved Domains (1) summary
    cl02536
    Location:7 → 51
    SAND; SAND domain

  2. NM_031803.2 → NP_113991.2  glucocorticoid modulatory element-binding protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    O88873, Q9JL86, Q9JL87, Q9JL88, Q9QUZ7
    UniProtKB/TrEMBL
    A6KM27, G3V7R3
    Related
    ENSRNOP00000049928.6, ENSRNOT00000044026.7
    Conserved Domains (1) summary
    smart00258
    Location:90 → 163
    SAND; SAND domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    188740210..188778377 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284662.1 → XP_063140732.1  glucocorticoid modulatory element-binding protein 2 isoform X1

  2. XM_063284663.1 → XP_063140733.1  glucocorticoid modulatory element-binding protein 2 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88873.1 GenPept UniProtKB/Swiss-Prot:O88873

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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