PXY Leucine-rich repeat protein kinase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PXY
Official Full Name: Leucine-rich repeat protein kinase family protein
Primary source: TAIR:AT5G61480
Locus tag: AT5G61480
See related: Araport:AT5G61480
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: MCI2.4; MCI2_4; PHLOEM INTERCALATED WITH XYLEM; TDIF receptor; TDR
Summary: Encodes PXY, a receptor-like kinase essential for maintaining polarity during plant vascular-tissue development.
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Genomic context

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See PXY in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 2

Sequence:: Chromosome: 5; NC_003076.8 (24724337..24728244, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A PXY-Mediated Transcriptional Network Integrates Signaling Mechanisms to Control Vascular Development in Arabidopsis.
Title: A PXY-Mediated Transcriptional Network Integrates Signaling Mechanisms to Control Vascular Development in Arabidopsis.
Loss of function by T-DNA insertion in C-terminally encoded peptide receptor 2 (CEPR2) together with phloem intercalated with xylem (PXY) and PXY-Like 2 (PXL2) led to abscisic acid (ABA) hypersensitivity, while CEPR2 overexpression led to ABA insensitivity compared with the wild type, indicating the redundant and negative roles of CEPR2, PXY, and PXL2 in ABA signaling.
Title: CEPR2 phosphorylates and accelerates the degradation of PYR/PYLs in Arabidopsis.
a conserved TDIF-recognition mechanism of TDR among plant species, is reported.
Title: Crystal structure of the plant receptor-like kinase TDR in complex with the TDIF peptide.
the crystal structure of TDIF in complex with its receptor PXY, a leucine-rich repeat receptor kinase (LRR-RK), is reported.
Title: Crystal structure of PXY-TDIF complex reveals a conserved recognition mechanism among CLE peptide-receptor pairs.
structures provide insights about the ligand perception and specific interactions between the CLE peptides and their cognate receptors
Title: Differential CLE peptide perception by plant receptors implicated from structural and functional analyses of TDIF-TDR interactions.
Data demonstrate that the PXY-CLE pathway has evolved to regulate secondary growth and manipulating this pathway can result in dramatically increased tree growth and productivity.
Title: Wood Formation in Trees Is Increased by Manipulating PXY-Regulated Cell Division.
This study delineates a TDIF-TDR-BIN2 signalling cascade that controls regulation of ARF and AUX/IAA interaction independent of auxin perception during lateral root development. [TDR]
Title: A secreted peptide acts on BIN2-mediated phosphorylation of ARFs to potentiate auxin response during lateral root development.
PXY and receptor kinase ERECTA (ER) affect the organisation of the vascular tissue but not the rate of cell division
Title: WOX4 and WOX14 act downstream of the PXY receptor kinase to regulate plant vascular proliferation independently of any role in vascular organisation.
We propose a model whereby vascular cell division is regulated both by PXY signalling and ethylene/ERF signalling
Title: Plant vascular cell division is maintained by an interaction between PXY and ethylene signalling.
Auxin-dependent stimulation of cambium activity depends on WOX4 and its upstream regulator PXY.
Title: WOX4 imparts auxin responsiveness to cambium cells in Arabidopsis.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_125541.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell division	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cell division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phloem or xylem histogenesis	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within phloem or xylem histogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in procambium histogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within secondary shoot formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xylem development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Leucine-rich repeat protein kinase family protein

NP_200956.1

PHLOEM INTERCALATED WITH XYLEM (PXY); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: plasma membrane; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: Leucine-rich repeat transmembrane protein kinase family protein (TAIR:AT4G28650.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

24724337..24728244 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_125541.2 → NP_200956.1 Leucine-rich repeat protein kinase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_200956.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9FII5

UniProtKB/TrEMBL

A0A178U8Y0, A0A5S9YH83, A0A654GD75

Conserved Domains (3) summary

PLN00113
Location:61 → 1000

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00031
Location:491 → 513

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:227 → 250

LRR_RI; leucine-rich repeat [structural motif]