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COB COBRA-like extracellular glycosyl-phosphatidyl inositol-anchored protein family [ Arabidopsis thaliana (thale cress) ]

Gene ID: 836213, updated on 18-Sep-2024

Summary

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Official Symbol
COB
Official Full Name
COBRA-like extracellular glycosyl-phosphatidyl inositol-anchored protein family
Primary source
TAIR:AT5G60920
Locus tag
AT5G60920
See related
Araport:AT5G60920
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
COBRA; MSL3.40; MSL3_40
Summary
Encodes a glycosylphosphatidylinositol-anchored protein localized primarily in the plasma membrane of the longitudinal sides of root cells. Necessary for oriented cell expansion in Arabidopsis. Cob mutants have abnormal roots that expand radially rather than longitudinally under certain growth conditions.
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Genomic context

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See COB in Genome Data Viewer
Location:
chromosome: 5
Exon count:
7
Sequence:
Chromosome: 5; NC_003076.8 (24511152..24514338, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene receptor-like protein kinase 1 Neighboring gene AGAMOUS-like 8 Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene Transducin/WD40 repeat-like superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cell identity mediates the response of Arabidopsis roots to abiotic stress. Dinneny JR, et al. Science, 2008 May 16. PMID 18436742
  2. Loss of function of COBRA, a determinant of oriented cell expansion, invokes cellular defence responses in Arabidopsis thaliana. Ko JH, et al. J Exp Bot, 2006. PMID 16873454
  3. Establishing and maintaining axial growth: wall mechanical properties and the cytoskeleton. Wasteneys GO, et al. J Plant Res, 2006 Jan. PMID 16284708
  4. COBRA encodes a putative GPI-anchored protein, which is polarly localized and necessary for oriented cell expansion in Arabidopsis. Schindelman G, et al. Genes Dev, 2001 May 1. PMID 11331607, Free PMC Article
  5. Identification of MEDIATOR16 as the Arabidopsis COBRA suppressor MONGOOSE1. Sorek N, et al. Proc Natl Acad Sci U S A, 2015 Dec 29. PMID 26655738, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that mutations in MEDIATOR16 (MED16) reduce the number of misregulated genes in cobra (cob-6) mutants and suppress the phenotypes.
    Title: Identification of MEDIATOR16 as the Arabidopsis COBRA suppressor MONGOOSE1.
  2. COBRA's function in maintaining anisotropic expansion may be microtubule-dependent.
    Title: Establishing and maintaining axial growth: wall mechanical properties and the cytoskeleton.
  3. Mutations within the COBRA gene that result in a loss of function result in abnormal cell growth throughout the entire plant body and the accumulation of massive amounts of stress response chemicals such as anthocyanins and callose.
    Title: Loss of function of COBRA, a determinant of oriented cell expansion, invokes cellular defence responses in Arabidopsis thaliana.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001345435.1
NM_125485.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cellulose microfibril organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellulose microfibril organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multidimensional cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to salt stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in longitudinal side of cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in plant-type cell wall IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
COBRA-like extracellular glycosyl-phosphatidyl inositol-anchored protein family
NP_568930.1
  • COBRA (COB); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: response to salt stress, multidimensional cell growth, cellulose microfibril organization; LOCATED IN: in 6 components; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Glycosyl-phosphatidyl inositol-anchored, plant (InterPro:IPR006918), COBRA-like (InterPro:IPR017391); BEST Arabidopsis thaliana protein match is: COBRA-like protein 1 precursor (TAIR:AT3G02210.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    24511152..24514338 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_125485.4 → NP_568930.1  COBRA-like extracellular glycosyl-phosphatidyl inositol-anchored protein family [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_568930.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O81811, Q8LDZ4, Q94KT8
    UniProtKB/TrEMBL
    A0A178UFZ7, A0A5S9YG34
    Conserved Domains (1) summary
    pfam04833
    Location:60 → 223
    COBRA; COBRA-like protein

  2. NM_001345435.1 → NP_001330939.1  COBRA-like extracellular glycosyl-phosphatidyl inositol-anchored protein family [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8BCB5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q94KT8.1

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