AGL8 AGAMOUS-like 8 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: AGL8
Official Full Name: AGAMOUS-like 8
Primary source: TAIR:AT5G60910
Locus tag: AT5G60910
See related: Araport:AT5G60910
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AGAMOUS-like 8; FRUITFULL; FUL; MSL3.30; MSL3_30
Summary: MADS box gene negatively regulated by APETALA1
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Genomic context

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See AGL8 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 9

Sequence:: Chromosome: 5; NC_003076.8 (24502434..24506269, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AabHLH48, a novel basic helix-loop-helix transcription factor from Adonis amurensis, promotes early flowering in Arabidopsis by activating FRUITFULL expression.
Title: AabHLH48, a novel basic helix-loop-helix transcription factor from Adonis amurensis, promotes early flowering in Arabidopsis by activating FRUITFULL expression.
Arrest, Senescence and Death of Shoot Apical Stem Cells in Arabidopsis thaliana.
Title: Arrest, Senescence and Death of Shoot Apical Stem Cells in Arabidopsis thaliana.
SEEDSTICK Controls Arabidopsis Fruit Size by Regulating Cytokinin Levels and FRUITFULL.
Title: SEEDSTICK Controls Arabidopsis Fruit Size by Regulating Cytokinin Levels and FRUITFULL.
Data show that FRUITFULL (FUL), a MADS-box gene involved in flowering and fruit development, has a key role in promoting meristem arrest, directly and negatively regulates APETALA2 expression in the shoot apical meristem.
Title: Genetic control of meristem arrest and life span in Arabidopsis by a FRUITFULL-APETALA2 pathway.
SAUR10 is repressed by FUL in stems and inflorescence branches. SAUR10 is specifically expressed at the abaxial side of these branches and this localized activity is influenced by hormones, light conditions and by FUL, which has an effect on branch angle.
Title: FRUITFULL controls SAUR10 expression and regulates Arabidopsis growth and architecture.
The sequential formation of FUL-SVP and FUL-SOC1 heterodimers may mediate the vegetative and meristem identity transitions, counteracting the repressive effect of FLC and SVP on flowering.
Title: Sequential action of FRUITFULL as a modulator of the activity of the floral regulators SVP and SOC1.
Flowering is controlled by AGL24 partly independently of SOC1 and FUL.
Title: AGL24 acts in concert with SOC1 and FUL during Arabidopsis floral transition.
Two cis-elements were involved in the repression of FUL expression. The first intron of FUL was shown to participate in the development of carpel and stamen as an enhancer.
Title: [Regulation pattern of the FRUITFULL (FUL) gene of Arabidopsis thaliana].
Data show that LEAFY, FRUITFULL, and APETALA1 are directly activated by the microRNA-targeted transcription factor SQUAMOSA PROMOTER BINDING PROTEIN-LIKE 3 (SPL3) to control the timing of flower formation.
Title: The microRNA-regulated SBP-Box transcription factor SPL3 is a direct upstream activator of LEAFY, FRUITFULL, and APETALA1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001085307.1

Supported by ESTs:

NM_125484.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in developmental growth involved in morphogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within fruit development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within maintenance of inflorescence meristem identity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of flower development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of flower development	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: AGAMOUS-like 8

NP_001078776.1

AGAMOUS-like 8 (AGL8); FUNCTIONS IN: sequence-specific DNA binding transcription factor activity; INVOLVED IN: positive regulation of flower development, maintenance of inflorescence meristem identity, fruit development; LOCATED IN: nucleus; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Transcription factor, K-box (InterPro:IPR002487); BEST Arabidopsis thaliana protein match is: K-box region and MADS-box transcription factor family protein (TAIR:AT1G69120.1); Has 3783 Blast hits to 3782 proteins in 618 species: Archae - 0; Bacteria - 2; Metazoa - 1; Fungi - 10; Plants - 3766; Viruses - 0; Other Eukaryotes - 4 (source: NCBI BLink).

NP_568929.1

AGAMOUS-like 8 (AGL8); FUNCTIONS IN: sequence-specific DNA binding transcription factor activity; INVOLVED IN: positive regulation of flower development, maintenance of inflorescence meristem identity, fruit development; LOCATED IN: nucleus; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Transcription factor, MADS-box (InterPro:IPR002100), Transcription factor, K-box (InterPro:IPR002487); BEST Arabidopsis thaliana protein match is: K-box region and MADS-box transcription factor family protein (TAIR:AT1G69120.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

24502434..24506269 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_125484.4 → NP_568929.1 AGAMOUS-like 8 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_568929.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q38876

UniProtKB/TrEMBL

A0A178UM96, A0A5S9YFW5

Conserved Domains (2) summary

cd00265
Location:2 → 79

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam01486
Location:84 → 173

K-box; K-box region
NM_001085307.1 → NP_001078776.1 AGAMOUS-like 8 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001078776.1

Status: REVIEWED

UniProtKB/TrEMBL

A8MRX9

Conserved Domains (1) summary

pfam01486
Location:22 → 109

K-box; K-box region