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RGF1 root meristem growth factor 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 836202, updated on 18-Sep-2024

Summary

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Official Symbol
RGF1
Official Full Name
root meristem growth factor 1
Primary source
TAIR:AT5G60810
Locus tag
AT5G60810
See related
Araport:AT5G60810
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
GLV11; GOLVEN 11; MAE1.14; MAE1_14; root meristem growth factor 1
Summary
Encodes a root meristem growth factor (RGF). Belongs to a family of functionally redundant homologous peptides that are secreted, tyrosine-sulfated, and expressed mainly in the stem cell area and the innermost layer of central columella cells. RGFs are required for maintenance of the root stem cell niche and transit amplifying cell proliferation. Members of this family include: At5g60810 (RGF1), At1g13620 (RGF2), At2g04025 (RGF3), At3g30350 (RGF4), At5g51451 (RGF5), At4g16515 (RGF6), At3g02240 (RGF7), At2g03830 (RGF8) and At5g64770 (RGF9).
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Genomic context

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See RGF1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
3
Sequence:
Chromosome: 5; NC_003076.8 (24466509..24467215, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene Putative membrane lipoprotein Neighboring gene RING/U-box superfamily protein Neighboring gene basic leucine-zipper 70 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The RGI1-BAK1 module acts as the main receptor-coreceptor pair for regulating primary root gravitropism and meristem activity in response to RGF1 peptide in Arabidopsis. Jeon BW, et al. Plant Signal Behav, 2023 Dec 31. PMID 37382066, Free PMC Article
  2. The YDA-MKK4/MKK5-MPK3/MPK6 Cascade Functions Downstream of the RGF1-RGI Ligand-Receptor Pair in Regulating Mitotic Activity in Root Apical Meristem. Shao Y, et al. Mol Plant, 2020 Nov 2. PMID 32916336
  3. RGF1 controls root meristem size through ROS signalling. Yamada M, et al. Nature, 2020 Jan. PMID 31801996, Free PMC Article
  4. Distinct sensitivities to phosphate deprivation suggest that RGF peptides play disparate roles in Arabidopsis thaliana root development. Cederholm HM, et al. New Phytol, 2015 Aug. PMID 25856240, Free PMC Article
  5. ROOT MERISTEM GROWTH FACTOR1 (RGF1)-RGF1 INSENSITIVE 1 peptide-receptor pair inhibits lateral root development via the MPK6-PUCHI module in Arabidopsis. Jeon BW, et al. J Exp Bot, 2023 Mar 13. PMID 36516421

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The RGI1-BAK1 module acts as the main receptor-coreceptor pair for regulating primary root gravitropism and meristem activity in response to RGF1 peptide in Arabidopsis.
    Title: The RGI1-BAK1 module acts as the main receptor-coreceptor pair for regulating primary root gravitropism and meristem activity in response to RGF1 peptide in Arabidopsis.
  2. ROOT MERISTEM GROWTH FACTOR1 (RGF1)-RGF1 INSENSITIVE 1 peptide-receptor pair inhibits lateral root development via the MPK6-PUCHI module in Arabidopsis.
    Title: ROOT MERISTEM GROWTH FACTOR1 (RGF1)-RGF1 INSENSITIVE 1 peptide-receptor pair inhibits lateral root development via the MPK6-PUCHI module in Arabidopsis.
  3. The YDA-MKK4/MKK5-MPK3/MPK6 Cascade Functions Downstream of the RGF1-RGI Ligand-Receptor Pair in Regulating Mitotic Activity in Root Apical Meristem.
    Title: The YDA-MKK4/MKK5-MPK3/MPK6 Cascade Functions Downstream of the RGF1-RGI Ligand-Receptor Pair in Regulating Mitotic Activity in Root Apical Meristem.
  4. Manipulating RITF1 expression leads to the redistribution of ROS along the root developmental zones
    Title: RGF1 controls root meristem size through ROS signalling.
  5. UBP12/13 are regulators of the RGF1-RGFR1-PLT1/2 signaling pathway and UBP12/13 can counteract RGF1-induced RGFR1 ubiquitination, stabilize RGFR1, and maintain root cell sensitivity to RGF1
    Title: Regulation of the stability of RGF1 receptor by the ubiquitin-specific proteases UBP12/UBP13 is critical for root meristem maintenance.
  6. A clade of leucine-rich repeat receptor-like kinases, designated as RGF1 INSENSITIVE 1 (RGI1) to RGI5, serving as receptors of RGF1, were identified.
    Title: RGF1 INSENSITIVE 1 to 5, a group of LRR receptor-like kinases, are essential for the perception of root meristem growth factor 1 in Arabidopsis thaliana.
  7. RGF2 influenced the longitudinal growth rate in the primary root in response to inorganic phosphate deprivation, whereas RGF1 affected circumferential cell number in the root meristem.
    Title: Distinct sensitivities to phosphate deprivation suggest that RGF peptides play disparate roles in Arabidopsis thaliana root development.
  8. root meristem growth factor 1(At5g60810 peptide) required for maintenance of root stem cell niche and transit amplifying cell proliferation; it defines expression levels and patterns of stem cell transcription factor PLETHORA
    Title: Secreted peptide signals required for maintenance of root stem cell niche in Arabidopsis.
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General gene information

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Homology

NM_001125996.2
NM_125474.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables growth factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptide receptor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to phosphate starvation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to phosphate starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lateral root development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of root meristem identity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of gene expression IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in post-transcriptional regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of asymmetric cell division ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of lateral root development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of root development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of root meristem growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of root meristem growth ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of root morphogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of root morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
root meristem growth factor 1
NP_001119468.1
  • root meristem growth factor 1 (RGF1); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: regulation of root meristem growth, positive regulation of gene expression; EXPRESSED IN: columella root cap initial cell, quiescent center; Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_200889.2
  • root meristem growth factor 1 (RGF1); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: regulation of root meristem growth, positive regulation of gene expression; LOCATED IN: endomembrane system; EXPRESSED IN: columella root cap initial cell, quiescent center; Has 4 Blast hits to 4 proteins in 2 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 4; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    24466509..24467215 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_125474.4 → NP_200889.2  root meristem growth factor 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_200889.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0MFQ8, B3H4B2, E5RQK8, Q1PDH0, Q3E880
    UniProtKB/TrEMBL
    A0A654GCW3

  2. NM_001125996.2 → NP_001119468.1  root meristem growth factor 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001119468.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q3E880
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3E880.2

Gene LinkOut

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Research Materials