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ATLIG4 DNA ligase IV [ Arabidopsis thaliana (thale cress) ]

Gene ID: 835822, updated on 18-Sep-2024

Summary

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Official Symbol
ATLIG4
Official Full Name
DNA ligase IV
Primary source
TAIR:AT5G57160
Locus tag
AT5G57160
See related
Araport:AT5G57160
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
DNA LIGASE IV; LIG4
Summary
Encodes the Arabidopsis orthologue of the yeast and mammalian DNA ligase IV. Involved in the repair of DNA damage but, unlike in yeast, not required for T-DNA integration. Interacts with the Arabidopsis homologue of XRCC4.
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Genomic context

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See ATLIG4 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
26
Sequence:
Chromosome: 5; NC_003076.8 (23154965..23161826, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Clp amino terminal domain-containing protein Neighboring gene purple acid phosphatase 28 Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene Tautomerase/MIF superfamily protein Neighboring gene chloroplast import apparatus 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Telomere dynamics and fusion of critically shortened telomeres in plants lacking DNA ligase IV. Heacock ML, et al. Nucleic Acids Res, 2007. PMID 17897968, Free PMC Article
  2. The Arabidopsis AtLIG4 gene is required for the repair of DNA damage, but not for the integration of Agrobacterium T-DNA. van Attikum H, et al. Nucleic Acids Res, 2003 Jul 15. PMID 12853643, Free PMC Article
  3. Involvement of AtPolλ in the repair of high salt- and DNA cross-linking agent-induced double strand breaks in Arabidopsis. Roy S, et al. Plant Physiol, 2013 Jun. PMID 23660835, Free PMC Article
  4. Arabidopsis DNA ligase IV is induced by gamma-irradiation and interacts with an Arabidopsis homologue of the double strand break repair protein XRCC4. West CE, et al. Plant J, 2000 Oct. PMID 11029705
  5. Rapid repair of DNA double strand breaks in Arabidopsis thaliana is dependent on proteins involved in chromosome structure maintenance. Kozak J, et al. DNA Repair (Amst), 2009 Mar 1. PMID 19070688

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DNA ligase IV (LIG4) is not essential for telomere joining.
    Title: Telomere dynamics and fusion of critically shortened telomeres in plants lacking DNA ligase IV.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001345245.1
NM_125098.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA ligase (ATP) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA ligase (ATP) activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in DNA integration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA ligation involved in DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within double-strand break repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within double-strand break repair via nonhomologous end joining IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to X-ray IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in plasmodesma HDA PubMed 

General protein information

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Preferred Names
DNA ligase IV
NP_568851.2
  • ATLIG4; FUNCTIONS IN: protein binding, DNA ligase (ATP) activity; INVOLVED IN: double-strand break repair, response to X-ray, response to DNA damage stimulus; LOCATED IN: intracellular; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold (InterPro:IPR012340), DNA ligase, N-terminal (InterPro:IPR012308), ATP dependent DNA ligase, central (InterPro:IPR012310), ATP dependent DNA ligase, C-terminal (InterPro:IPR012309), ATP-dependent DNA ligase, conserved site (InterPro:IPR016059), ATP-dependent DNA ligase (InterPro:IPR000977), BRCT (InterPro:IPR001357); BEST Arabidopsis thaliana protein match is: DNA ligase 1 (TAIR:AT1G08130.1); Has 7656 Blast hits to 6618 proteins in 1076 species: Archae - 317; Bacteria - 1869; Metazoa - 2250; Fungi - 907; Plants - 304; Viruses - 214; Other Eukaryotes - 1795 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    23154965..23161826 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_125098.4 → NP_568851.2  DNA ligase IV [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_568851.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LL84, Q9LU70
    UniProtKB/TrEMBL
    A0A178UKD7, A0A5S9YH46
    Conserved Domains (4) summary
    PTZ00121
    Location:909 → 1180
    PTZ00121; MAEBL; Provisional
    TIGR00574
    Location:61 → 600
    dnl1; DNA ligase I, ATP-dependent (dnl1)
    cd17717
    Location:802 → 898
    BRCT_DNA_ligase_IV_rpt2; second BRCT domain of DNA ligase 4 (LIG4) and similar proteins
    cd17722
    Location:655 → 741
    BRCT_DNA_ligase_IV_rpt1; first BRCT domain of DNA ligase 4 (LIG4) and similar proteins

  2. NM_001345245.1 → NP_001332576.1  DNA ligase IV [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8BHE2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LL84.1

Gene LinkOut

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