U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ACA8 autoinhibited Ca2+ -ATPase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 835815, updated on 24-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
ACA8
Official Full Name
autoinhibited Ca2+ -ATPase
Primary source
TAIR:AT5G57110
Locus tag
AT5G57110
See related
Araport:AT5G57110
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
''autoinhibited Ca2+ -ATPase; ''AUTOINHIBITED CA2+ -ATPASE; 'autoinhibited Ca2+ -ATPase; AT-ACA8; autoinhibited Ca2+ -ATPase; AUTOINHIBITED CA2+ -ATPASE; isoform 8; ISOFORM 8; isoform 8'; isoform 8''; ISOFORM 8''; MUL3.5; MUL3_5
Summary
Arabidopsis-autoinhibited Ca2+ -ATPase, isoform 8, contains all of the characteristic motifs of Ca2+ -transporting P-type Ca2+ -ATPases and is localized to the plasma membrane.
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ACA8 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
36
Sequence:
Chromosome: 5; NC_003076.8 (23109438..23117686, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Auxin efflux carrier family protein Neighboring gene Nucleotide/sugar transporter family protein Neighboring gene nucleolar/coiled-body phosphoprotein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Conserved N-terminal Regulation of the ACA8 Calcium Pump with Two Calmodulin Binding Sites. Larsen ST, et al. J Mol Biol, 2024 Oct 15. PMID 39168442
  2. At-ACA8 encodes a plasma membrane-localized calcium-ATPase of Arabidopsis with a calmodulin-binding domain at the N terminus. Bonza MC, et al. Plant Physiol, 2000 Aug. PMID 10938365, Free PMC Article
  3. Functional expression in yeast of an N-deleted form of At-ACA8, a plasma membrane Ca(2+)-ATPase of Arabidopsis thaliana, and characterization of a hyperactive mutant. Bonza MC, et al. Planta, 2004 Mar. PMID 14648121
  4. Ca2+-dependent phosphoregulation of the plasma membrane Ca2+-ATPase ACA8 modulates stimulus-induced calcium signatures. Costa A, et al. J Exp Bot, 2017 Jun 1. PMID 28531251, Free PMC Article
  5. The plasma membrane-localised Ca(2+)-ATPase ACA8 plays a role in sucrose signalling involved in early seedling development in Arabidopsis. Zhang J, et al. Plant Cell Rep, 2014 May. PMID 24585188

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Conserved N-terminal Regulation of the ACA8 Calcium Pump with Two Calmodulin Binding Sites.
    Title: Conserved N-terminal Regulation of the ACA8 Calcium Pump with Two Calmodulin Binding Sites.
  2. This study indicates that ACA10/8 and BON1 physically interact on plasma membrane and function in the generation of cytosol calcium signatures that are critical for stomatal movement and impact plant immunity.
    Title: Calcium Pumps and Interacting BON1 Protein Modulate Calcium Signature, Stomatal Closure, and Plant Immunity.
  3. This study identifies ACA8 as a prominent in vivo regulator of cellular Ca2+ dynamics and reveal the existence of a Ca2+-dependent CBL-CIPK-mediated regulatory feedback mechanism, which crucially functions in the termination of Ca2+ signals.
    Title: Ca2+-dependent phosphoregulation of the plasma membrane Ca2+-ATPase ACA8 modulates stimulus-induced calcium signatures.
  4. CML36 interacts directly with the regulative N terminus of the Arabidopsis plasma membrane Ca(2+)-ATPase isoform 8 (ACA8) and this interaction stimulates ACA8 activity
    Title: Arabidopsis calmodulin-like protein CML36 is a calcium (Ca(2+)) sensor that interacts with the plasma membrane Ca(2+)-ATPase isoform ACA8 and stimulates its activity.
  5. ACA8-mediated Ca(2+) signalling contributes to modulate early seedling development and coordinates root development with nutrient availability.
    Title: The plasma membrane-localised Ca(2+)-ATPase ACA8 plays a role in sucrose signalling involved in early seedling development in Arabidopsis.
  6. ACA8 and ACA10 contribute to plant immunity and have a role in plant development.
    Title: Plasma membrane calcium ATPases are important components of receptor-mediated signaling in plant immune responses and development.
  7. Phosphorylation of serine residues in the N-terminus modulates the activity of ACA8, a plasma membrane Ca2+-ATPase of Arabidopsis thaliana.
    Title: Phosphorylation of serine residues in the N-terminus modulates the activity of ACA8, a plasma membrane Ca2+-ATPase of Arabidopsis thaliana.
  8. regulatory domain works independently of its terminal localization
    Title: Plant and animal type 2B Ca2+-ATPases: evidence for a common auto-inhibitory mechanism.
  9. complex between calmodulin and the regulatory domain of the plasma-membrane Ca(2+)-ATPase ACA8 from Arabidopsis has been crystallized. Crystals belonged to space group C2, with unit-cell parameters a = 176.8, b = 70.0, c = 69.8 A, beta = 113.2 degrees.
    Title: Expression, purification, crystallization and preliminary X-ray analysis of calmodulin in complex with the regulatory domain of the plasma-membrane Ca2+-ATPase ACA8.
  10. The small cytoplasmic loop of a type 2B Ca(2+)-ATPase plays a role in the attainment of the auto-inhibited state.
    Title: Single point mutations in the small cytoplasmic loop of ACA8, a plasma membrane Ca2+-ATPase of Arabidopsis thaliana, generate partially deregulated pumps.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

NM_001345242.1
NM_125093.6
NM_180869.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables P-type calcium transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables P-type calcium transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables calmodulin binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to nematode HEP PubMed 
Component Evidence Code Pubs
located_in plasma membrane HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasmodesma HDA PubMed 
located_in plastid HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
autoinhibited Ca2+ -ATPase
NP_200521.3
  • ''autoinhibited Ca2+ -ATPase, isoform 8'' (ACA8); FUNCTIONS IN: protein self-association, calcium-transporting ATPase activity, calmodulin binding; INVOLVED IN: response to nematode; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, P-type, ATPase-associated domain (InterPro:IPR008250), ATPase, P-type, calcium-transporting, PMCA-type (InterPro:IPR006408), Haloacid dehalogenase-like hydrolase (InterPro:IPR005834), ATPase, P-type cation-transporter, N-terminal (InterPro:IPR004014), ATPase, P-type, H+ transporting proton pump (InterPro:IPR000695), ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (InterPro:IPR001757), ATPase, P-type cation-transporter, C-terminal (InterPro:IPR006068), ATPase, P-type phosphorylation site (InterPro:IPR018303); BEST Arabidopsis thaliana protein match is: autoinhibited Ca(2+)-ATPase 10 (TAIR:AT4G29900.1); Has 45517 Blast hits to 34552 proteins in 3221 species: Archae - 872; Bacteria - 31142; Metazoa - 4022; Fungi - 2709; Plants - 2112; Viruses - 3; Other Eukaryotes - 4657 (source: NCBI BLink).
NP_851200.1
  • ''autoinhibited Ca2+ -ATPase, isoform 8'' (ACA8); FUNCTIONS IN: protein self-association, calcium-transporting ATPase activity, calmodulin binding; INVOLVED IN: response to nematode; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, P-type, ATPase-associated domain (InterPro:IPR008250), ATPase, P-type, calcium-transporting, PMCA-type (InterPro:IPR006408), ATPase, P-type, H+ transporting proton pump (InterPro:IPR000695), ATPase, P-type cation-transporter, N-terminal (InterPro:IPR004014), Haloacid dehalogenase-like hydrolase (InterPro:IPR005834), ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (InterPro:IPR001757), ATPase, P-type phosphorylation site (InterPro:IPR018303), ATPase, P-type cation-transporter, C-terminal (InterPro:IPR006068); BEST Arabidopsis thaliana protein match is: autoinhibited Ca(2+)-ATPase 10 (TAIR:AT4G29900.1); Has 45378 Blast hits to 34457 proteins in 3207 species: Archae - 868; Bacteria - 31014; Metazoa - 4020; Fungi - 2704; Plants - 2112; Viruses - 3; Other Eukaryotes - 4657 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    23109438..23117686 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_125093.6 → NP_200521.3  autoinhibited Ca2+ -ATPase, isoform 8 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_200521.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LF79, Q9LU75
    UniProtKB/TrEMBL
    A0A178UCR0, A0A384L942, B9DH83, Q0WV19
    Conserved Domains (2) summary
    TIGR01517
    Location:133 → 1047
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12515
    Location:30 → 71
    CaATP_NAI; Ca2+-ATPase N terminal autoinhibitory domain

  2. NM_180869.3 → NP_851200.1  autoinhibited Ca2+ -ATPase, isoform 8 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_851200.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LF79, Q9LU75
    UniProtKB/TrEMBL
    A0A178UCR0, A0A384L942, B9DH83, Q0WV19
    Conserved Domains (2) summary
    TIGR01517
    Location:133 → 1047
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12515
    Location:30 → 71
    CaATP_NAI; Ca2+-ATPase N terminal autoinhibitory domain

  3. NM_001345242.1 → NP_001331281.1  autoinhibited Ca2+ -ATPase, isoform 8 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LF79, Q9LU75
    UniProtKB/TrEMBL
    A0A178UCR0, A0A384L942, B9DH83, Q0WV19
    Conserved Domains (2) summary
    TIGR01517
    Location:133 → 1047
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12515
    Location:30 → 71
    CaATP_NAI; Ca2+-ATPase N terminal autoinhibitory domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LF79.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools