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CBL2 calcineurin B-like protein 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 835697, updated on 18-Sep-2024

Summary

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Official Symbol
CBL2
Official Full Name
calcineurin B-like protein 2
Primary source
TAIR:AT5G55990
Locus tag
AT5G55990
See related
Araport:AT5G55990
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATCBL2; calcineurin B-like protein 2; MDA7.3; MDA7_3; SCaBP1; SOS3-LIKE CALCIUM BINDING PROTEIN 1
Summary
Encodes a member of the Arabidopsis CBL (Calcineurin B-like Calcium Sensor) protein family.
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Genomic context

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See CBL2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
11
Sequence:
Chromosome: 5; NC_003076.8 (22671113..22674100)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene RING/U-box superfamily protein Neighboring gene serine-rich protein-like protein Neighboring gene HEAT SHOCK PROTEIN 81.4 Neighboring gene heat shock protein 81-3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The crystal structure of plant-specific calcium-binding protein AtCBL2 in complex with the regulatory domain of AtCIPK14. Akaboshi M, et al. J Mol Biol, 2008 Mar 14. PMID 18237745
  2. The vacuolar calcium sensors CBL2 and CBL3 affect seed size and embryonic development in Arabidopsis thaliana. Eckert C, et al. Plant J, 2014 Apr. PMID 24479654
  3. Dual fatty acyl modification determines the localization and plasma membrane targeting of CBL/CIPK Ca2+ signaling complexes in Arabidopsis. Batistic O, et al. Plant Cell, 2008 May. PMID 18502848, Free PMC Article
  4. Calcineurin B-Like Protein-Interacting Protein Kinase CIPK21 Regulates Osmotic and Salt Stress Responses in Arabidopsis. Pandey GK, et al. Plant Physiol, 2015 Sep. PMID 26198257, Free PMC Article
  5. Vacuolar CBL-CIPK12 Ca(2+)-sensor-kinase complexes are required for polarized pollen tube growth. Steinhorst L, et al. Curr Biol, 2015 Jun 1. PMID 25936548

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. crucial regulator of vacuolar dynamics and polarized pollen tube growth
    Title: Vacuolar CBL-CIPK12 Ca(2+)-sensor-kinase complexes are required for polarized pollen tube growth.
  2. the calcium-independent activation of PKS24 by SCaBP1 is dependent on interaction of PKS24 with the C-terminal tail of SCaBP1. [SCaBP1]
    Title: A calcium-independent activation of the Arabidopsis SOS2-like protein kinase24 by its interacting SOS3-like calcium binding protein1.
  3. While single cbl2 or cbl3 mutants did not display discernable phenotypes, cbl2/cbl3 mutants exhibited defects in vegetative growth and were severely impaired in seed development and morphology.
    Title: The vacuolar calcium sensors CBL2 and CBL3 affect seed size and embryonic development in Arabidopsis thaliana.
  4. CBL2-GFP exhibited dynamic patterns of subcellular localization, including several endomembrane compartments, the apical plasma membrane (PM), and cytoskeleton-like structures in pollen tubes. v
    Title: A genome-wide functional characterization of Arabidopsis regulatory calcium sensors in pollen tubes.
  5. Structural comparison of the two structures shows that the recognition of CBL by CIPK is performed in a similar manner, but inherent interactions confer binding affinity and specificity.
    Title: The crystal structure of plant-specific calcium-binding protein AtCBL2 in complex with the regulatory domain of AtCIPK14.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_124981.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within calcium-mediated signaling TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within potassium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosolic ribosome HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plant-type vacuole HDA PubMed 
located_in plant-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plastid HDA PubMed 
located_in vacuole HDA PubMed 

General protein information

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Preferred Names
calcineurin B-like protein 2
NP_200410.1
  • calcineurin B-like protein 2 (CBL2); FUNCTIONS IN: calcium ion binding; INVOLVED IN: calcium-mediated signaling; LOCATED IN: cytosolic ribosome, plant-type vacuole membrane, vacuole, membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Recoverin (InterPro:IPR001125), EF-HAND 2 (InterPro:IPR018249), Calcineurin B protein (InterPro:IPR015757), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048); BEST Arabidopsis thaliana protein match is: calcineurin B-like 3 (TAIR:AT4G26570.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    22671113..22674100
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001345176.1 → NP_001332655.1  calcineurin B-like protein 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O81446, Q8LAS7
    UniProtKB/TrEMBL
    A0A178UCE4, A0A654GBV2
    Conserved Domains (1) summary
    COG5126
    Location:36 → 198
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  2. NM_124981.4 → NP_200410.1  calcineurin B-like protein 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_200410.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O81446, Q8LAS7
    UniProtKB/TrEMBL
    A0A178UCE4, A0A654GBV2
    Conserved Domains (1) summary
    COG5126
    Location:36 → 198
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8LAS7.2

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