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KCO1 Outward rectifying potassium channel protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 835657, updated on 18-Sep-2024

Summary

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Official Symbol
KCO1
Official Full Name
Outward rectifying potassium channel protein
Primary source
TAIR:AT5G55630
Locus tag
AT5G55630
See related
Araport:AT5G55630
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATKCO1; ATTPK1; CA2+ ACTIVATED OUTWARD RECTIFYING K+ CHANNEL 1; MDF20.7; MDF20_7; TANDEM PORE K+ CHANNEL 1; TPK1; TWO PORE K CHANNEL; TWO PORE K CHANNEL 1
Summary
Encodes AtTPK1 (KCO1), a member of the Arabidopsis thaliana K+ channel family of AtTPK/KCO proteins. AtTPK1 is targeted to the vacuolar membrane. Forms homomeric ion channels in vivo. Voltage-independent and Ca2+-activated K+ channel. Activated by 14-3-3 proteins.
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Genomic context

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See KCO1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
3
Sequence:
Chromosome: 5; NC_003076.8 (22531358..22533122)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene uncharacterized protein Neighboring gene Na-translocating NADH-quinone reductase subunit A Neighboring gene uncharacterized protein Neighboring gene DEK domain-containing chromatin associated protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Assembly and sorting of the tonoplast potassium channel AtTPK1 and its turnover by internalization into the vacuole. Maîtrejean M, et al. Plant Physiol, 2011 Aug. PMID 21697507, Free PMC Article
  2. Targeting of vacuolar membrane localized members of the TPK channel family. Dunkel M, et al. Mol Plant, 2008 Nov. PMID 19825594
  3. The two-pore channel TPK1 gene encodes the vacuolar K+ conductance and plays a role in K+ homeostasis. Gobert A, et al. Proc Natl Acad Sci U S A, 2007 Jun 19. PMID 17563365, Free PMC Article
  4. TPK1 is a vacuolar ion channel different from the slow-vacuolar cation channel. Bihler H, et al. Plant Physiol, 2005 Sep. PMID 16113216, Free PMC Article
  5. Vacuolar membrane localization of the Arabidopsis 'two-pore' K+ channel KCO1. Czempinski K, et al. Plant J, 2002 Mar. PMID 12148538

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ATKCO1 can form functional potassium transport systems in E. coli
    Title: Arabidopsis thaliana vacuolar TPK channels form functional K⁺ uptake pathways in Escherichia coli.
  2. an essential role of the vacuolar potassium channel TPK1 in salt-stress adaptation
    Title: Salt stress triggers phosphorylation of the Arabidopsis vacuolar K+ channel TPK1 by calcium-dependent protein kinases (CDPKs).
  3. TPK1 must assemble correctly to pass endoplasmic reticulum quality control.
    Title: Assembly and sorting of the tonoplast potassium channel AtTPK1 and its turnover by internalization into the vacuole.
  4. findings show that AtTPK1 (KCO1), interacts with 14-3-3 proteins (general regulating factors, GRFs; TPK1 seems to provide for a Ca(2+)- and 14-3-3-sensitive mechanism capable of controlling cytoplasmic potassium homeostasis in plants
    Title: TPK1, a Ca(2+)-regulated Arabidopsis vacuole two-pore K(+) channel is activated by 14-3-3 proteins.
  5. data clearly demonstrate that TPK1 (KCO1) is a voltage-independent, Ca(2+)-activated, K(+)-selective ion channel in the vacuolar membrane that does not mediate SV-type ionic currents [TPK1]
    Title: TPK1 is a vacuolar ion channel different from the slow-vacuolar cation channel.
  6. The two-pore channel TPK1 gene encodes the vacuolar K+ conductance and plays a role in K+ homeostasis.
    Title: The two-pore channel TPK1 gene encodes the vacuolar K+ conductance and plays a role in K+ homeostasis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_124945.4
NM_180865.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables calcium-activated potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables outward rectifier potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables outward rectifier potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to electrical stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within intracellular potassium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within potassium ion export across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within potassium ion import across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of seed germination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of stomatal movement IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
colocalizes_with vacuolar membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vacuolar membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Outward rectifying potassium channel protein
NP_200374.1
  • TWO PORE K CHANNEL (KCO1); CONTAINS InterPro DOMAIN/s: Potassium channel, two pore-domain (InterPro:IPR003280), EF-Hand 1, calcium-binding site (InterPro:IPR018247), Ion transport 2 (InterPro:IPR013099); BEST Arabidopsis thaliana protein match is: Ca2+ activated outward rectifying K+ channel 5 (TAIR:AT4G01840.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
NP_851196.1
  • ATKCO1; CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), Potassium channel, two pore-domain (InterPro:IPR003280), Ion transport 2 (InterPro:IPR013099); BEST Arabidopsis thaliana protein match is: Ca2+ activated outward rectifying K+ channel 5 (TAIR:AT4G01840.1); Has 4513 Blast hits to 4370 proteins in 1126 species: Archae - 145; Bacteria - 2057; Metazoa - 1231; Fungi - 181; Plants - 220; Viruses - 0; Other Eukaryotes - 679 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    22531358..22533122
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_124945.4 → NP_200374.1  Outward rectifying potassium channel protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_200374.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O04718, Q0WNY4, Q8LBL1, Q9FM75
    UniProtKB/TrEMBL
    A0A178URA8, A0A5S9YEU9
    Conserved Domains (2) summary
    COG5126
    Location:235 → 353
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    pfam07885
    Location:202 → 277
    Ion_trans_2; Ion channel

  2. NM_180865.1 → NP_851196.1  Outward rectifying potassium channel protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_851196.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O04718, Q0WNY4, Q8LBL1, Q9FM75
    UniProtKB/TrEMBL
    A0A178URA8, A0A5S9YEU9
    Conserved Domains (2) summary
    COG5126
    Location:235 → 353
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    pfam07885
    Location:202 → 277
    Ion_trans_2; Ion channel
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8LBL1.2

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