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TOP1BETA DNA topoisomerase 1 beta [ Arabidopsis thaliana (thale cress) ]

Gene ID: 835624, updated on 18-Sep-2024

Summary

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Official Symbol
TOP1BETA
Official Full Name
DNA topoisomerase 1 beta
Primary source
TAIR:AT5G55310
Locus tag
AT5G55310
See related
Araport:AT5G55310
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
DNA topoisomerase 1 beta; DNA topoisomerase I alpha; MTE17.2; MTE17_2; TOP1; TOP1ALPHA; TOPOISOMERASE 1
Summary
Encodes one of two Arabidopsis type-I DNA topoisomerase I genes. Reducing the level of expression of this gene in a top1alpha (At5g55300) mutant background causes seedling lethality.
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Genomic context

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See TOP1BETA in Genome Data Viewer
Location:
chromosome: 5
Exon count:
16
Sequence:
Chromosome: 5; NC_003076.8 (22430105..22435134, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ATPase, V0 complex, subunit E Neighboring gene DNA topoisomerase I alpha Neighboring gene MBOAT (membrane bound O-acyl transferase) family protein Neighboring gene MBOAT (membrane bound O-acyl transferase) family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Disruption of a DNA topoisomerase I gene affects morphogenesis in Arabidopsis. Takahashi T, et al. Plant Cell, 2002 Sep. PMID 12215507, Free PMC Article
  2. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article
  3. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_124913.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA topoisomerase type I (single strand cut, ATP-independent) activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA topological change IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
DNA topoisomerase 1 beta
NP_200342.1
  • DNA topoisomerase 1 beta (TOP1BETA); FUNCTIONS IN: DNA topoisomerase type I activity; INVOLVED IN: DNA topological change; LOCATED IN: membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: DNA topoisomerase I, DNA binding, mixed alpha/beta motif, eukaryotic-type (InterPro:IPR013030), DNA topoisomerase I, DNA binding, eukaryotic-type (InterPro:IPR008336), DNA topoisomerase I, C-terminal (InterPro:IPR001631), DNA topoisomerase I, active site (InterPro:IPR018521), DNA topoisomerase I, catalytic core, alpha/beta subdomain, eukaryotic-type (InterPro:IPR014727), DNA topoisomerase I, catalytic core, eukaryotic-type (InterPro:IPR013500), DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type (InterPro:IPR014711), DNA topoisomerase I, C-terminal, eukaryotic-type (InterPro:IPR013499), DNA breaking-rejoining enzyme, catalytic core (InterPro:IPR011010); BEST Arabidopsis thaliana protein match is: DNA topoisomerase I alpha (TAIR:AT5G55300.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    22430105..22435134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_124913.4 → NP_200342.1  DNA topoisomerase 1 beta [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_200342.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FJ79
    UniProtKB/TrEMBL
    A0A178UT82, A0A5S9YEC9, A0A654GB65
    Conserved Domains (2) summary
    smart00435
    Location:508 → 884
    TOPEUc; DNA Topoisomerase I (eukaryota)
    pfam02919
    Location:367 → 579
    Topoisom_I_N; Eukaryotic DNA topoisomerase I, DNA binding fragment
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FJ79.1

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