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PORA protochlorophyllide oxidoreductase A [ Arabidopsis thaliana (thale cress) ]

Gene ID: 835507, updated on 18-Sep-2024

Summary

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Official Symbol
PORA
Official Full Name
protochlorophyllide oxidoreductase A
Primary source
TAIR:AT5G54190
Locus tag
AT5G54190
See related
Araport:AT5G54190
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
K18G13.7; K18G13_7; protochlorophyllide oxidoreductase A
Summary
light-dependent NADPH:protochlorophyllide oxidoreductase A
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Genomic context

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See PORA in Genome Data Viewer
Location:
chromosome: 5
Exon count:
4
Sequence:
Chromosome: 5; NC_003076.8 (21990864..21992814, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene plastid transcriptionally active 15 Neighboring gene miscRNA Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MGDG, PG and SQDG regulate the activity of light-dependent protochlorophyllide oxidoreductase. Gabruk M, et al. Biochem J, 2017 Mar 23. PMID 28188256
  2. Insight into the oligomeric structure of PORA from A. thaliana. Gabruk M, et al. Biochim Biophys Acta, 2016 Dec. PMID 27693048
  3. Arabidopsis light-dependent NADPH: protochlorophyllide oxidoreductase A (PORA) is essential for normal plant growth and development: an addendum. Kim C, et al. Plant Mol Biol, 2012 Sep. PMID 22850939
  4. Arabidopsis light-dependent protochlorophyllide oxidoreductase A (PORA) is essential for normal plant growth and development. Paddock T, et al. Plant Mol Biol, 2012 Mar. PMID 22278767
  5. Cell growth defect factor 1 is crucial for the plastid import of NADPH:protochlorophyllide oxidoreductase A in Arabidopsis thaliana. Reinbothe S, et al. Proc Natl Acad Sci U S A, 2015 May 5. PMID 25901327, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Photocatalytic LPOR forms helical lattices that shape membranes for chlorophyll synthesis.
    Title: Photocatalytic LPOR forms helical lattices that shape membranes for chlorophyll synthesis.
  2. The catalytic motifs of adjacent subunits become close to each other upon binding of substrates. Identified two mutations of PORA that disturbed its oligomerisation properties: Delta85-88 and Delta240-270. Additionally, a complete loss of the catalytic activity was observed for the following mutations: Delta189-194, Delta240-270, Delta318-331 and Delta392-393.
    Title: Insight into the oligomeric structure of PORA from A. thaliana.
  3. Monogalactosyldiacylglycerol, phosphatidylglycerol and sulfoquinovosyl diacylglycerol regulate the activity of light-dependent protochlorophyllide oxidoreductase.
    Title: MGDG, PG and SQDG regulate the activity of light-dependent protochlorophyllide oxidoreductase.
  4. reconstituted Pchlide-POR-NADPH complexes showed fluorescence maxima at 77 K
    Title: Photoactive protochlorophyllide-enzyme complexes reconstituted with PORA, PORB and PORC proteins of A. thaliana: fluorescence and catalytic properties.
  5. Cell growth defect factor 1 has a critical role in plastid import of NADPH: protochlorophyllide oxidoreductase A in Arabidopsis thaliana
    Title: Cell growth defect factor 1 is crucial for the plastid import of NADPH:protochlorophyllide oxidoreductase A in Arabidopsis thaliana.
  6. Results suggest that the lack of stomata in porA-1 may contribute to the dwarfed phenotype of the mutant and the essential role of PORA during plant development and stomata formation.
    Title: Arabidopsis light-dependent NADPH: protochlorophyllide oxidoreductase A (PORA) is essential for normal plant growth and development: an addendum.
  7. PORA-specific functions in photomorphogenesis and plant development, especially in etioplast development
    Title: Arabidopsis light-dependent protochlorophyllide oxidoreductase A (PORA) is essential for normal plant growth and development.
  8. In response to illumination, light-dependent chlorophyll production, thylakoid stacking and photomorphogenesis are also restored in PORA-overexpressing porB-1 porC-1 seedlings and adult plants.
    Title: Arabidopsis protochlorophyllide oxidoreductase A (PORA) restores bulk chlorophyll synthesis and normal development to a porB porC double mutant.
  9. Interaction of Toc33 and Oep16 with PORA protein transport in A. thaliana.
    Title: A role of Toc33 in the protochlorophyllide-dependent plastid import pathway of NADPH:protochlorophyllide oxidoreductase (POR) A.
  10. The analysis of PORA and PORB import into plastids of intact seedlings revealed an unexpected multiplicity of import routes that differed by their substrate, cell, tissue and organ specificities.
    Title: Multiplicity of different cell- and organ-specific import routes for the NADPH-protochlorophyllide oxidoreductases A and B in plastids of Arabidopsis seedlings.
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Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001036995.1
NM_124799.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protochlorophyllide reductase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protochlorophyllide reductase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables protochlorophyllide reductase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in chlorophyll biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chlorophyll biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in photomorphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to ethylene IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in skotomorphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast NAS
Non-traceable Author Statement
more info
 PubMed 
located_in chloroplast envelope HDA PubMed 
located_in chloroplast thylakoid HDA PubMed 

General protein information

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Preferred Names
protochlorophyllide oxidoreductase A
NP_001032072.1
  • protochlorophyllide oxidoreductase A (PORA); FUNCTIONS IN: oxidoreductase activity, protochlorophyllide reductase activity; INVOLVED IN: chlorophyll biosynthetic process, response to ethylene stimulus; LOCATED IN: chloroplast; EXPRESSED IN: 11 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Light-dependent protochlorophyllide reductase (InterPro:IPR005979), NAD(P)-binding domain (InterPro:IPR016040), Short-chain dehydrogenase/reductase SDR (InterPro:IPR002198); BEST Arabidopsis thaliana protein match is: protochlorophyllide oxidoreductase B (TAIR:AT4G27440.2); Has 5533 Blast hits to 5523 proteins in 759 species: Archae - 38; Bacteria - 1884; Metazoa - 1114; Fungi - 682; Plants - 679; Viruses - 0; Other Eukaryotes - 1136 (source: NCBI BLink).
NP_200230.1
  • protochlorophyllide oxidoreductase A (PORA); FUNCTIONS IN: oxidoreductase activity, protochlorophyllide reductase activity; INVOLVED IN: chlorophyll biosynthetic process, response to ethylene stimulus; LOCATED IN: chloroplast; EXPRESSED IN: 11 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Light-dependent protochlorophyllide reductase (InterPro:IPR005979), NAD(P)-binding domain (InterPro:IPR016040), Glucose/ribitol dehydrogenase (InterPro:IPR002347), Short-chain dehydrogenase/reductase SDR (InterPro:IPR002198); BEST Arabidopsis thaliana protein match is: protochlorophyllide oxidoreductase B (TAIR:AT4G27440.2); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    21990864..21992814 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_124799.4 → NP_200230.1  protochlorophyllide oxidoreductase A [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_200230.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DGY6, Q42536, Q9FK22
    UniProtKB/TrEMBL
    A0A178UR02, A0A5S9YDU5
    Conserved Domains (1) summary
    PLN00015
    Location:96 → 403
    PLN00015; protochlorophyllide reductase

  2. NM_001036995.1 → NP_001032072.1  protochlorophyllide oxidoreductase A [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001032072.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q42536
    Conserved Domains (1) summary
    PLN00015
    Location:1 → 282
    PLN00015; protochlorophyllide reductase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q42536.2

Gene LinkOut

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