FIB1 fibrillarin 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: FIB1
Official Full Name: fibrillarin 1
Primary source: TAIR:AT5G52470
Locus tag: AT5G52470
See related: Araport:AT5G52470
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATFBR1; ATFIB1; FBR1; fibrillarin 1; FIBRILLARIN 1; K24M7.22; K24M7_22; SKIP7; SKP1/ASK1-INTERACTING PROTEIN
Summary: encodes a fibrillarin, a key nucleolar protein in eukaryotes which associates with box C/D small nucleolar RNAs (snoRNAs) directing 2'-O-ribose methylation of the rRNA. This gene also encodes a novel box C/D snoRNA, U60.1f in its fifth intron that accumulates in seedlings and that their targeted residue on the 25 S rRNA is methylated.
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Genomic context

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See FIB1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 7

Sequence:: Chromosome: 5; NC_003076.8 (21294147..21296819)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001125946.1

Supported by ESTs:

NM_124626.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables snoRNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA methylation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within rRNA processing	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in nucleolus	HDA more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
located_in plastid	HDA more info	PubMed

General protein information

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Preferred Names: fibrillarin 1

NP_001119418.1

fibrillarin 1 (FIB1); FUNCTIONS IN: snoRNA binding; INVOLVED IN: RNA methylation, rRNA processing; LOCATED IN: nucleolus, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Fibrillarin (InterPro:IPR000692); BEST Arabidopsis thaliana protein match is: fibrillarin 2 (TAIR:AT4G25630.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NP_568772.3

fibrillarin 1 (FIB1); FUNCTIONS IN: snoRNA binding; INVOLVED IN: RNA methylation, rRNA processing; LOCATED IN: nucleolus, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Fibrillarin (InterPro:IPR000692); BEST Arabidopsis thaliana protein match is: fibrillarin 2 (TAIR:AT4G25630.1); Has 20161 Blast hits to 7736 proteins in 898 species: Archae - 267; Bacteria - 4851; Metazoa - 6936; Fungi - 1342; Plants - 4220; Viruses - 452; Other Eukaryotes - 2093 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

21294147..21296819

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_124626.5 → NP_568772.3 fibrillarin 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_568772.3

Status: REVIEWED

UniProtKB/Swiss-Prot

B3H6E7, Q0WLG3, Q9FEF8, Q9FUZ8, Q9SP30

UniProtKB/TrEMBL

A0A178UA89, A0A5S9YDW7, A0A654GA95

Conserved Domains (1) summary

PTZ00146
Location:64 → 304

PTZ00146; fibrillarin; Provisional
NM_001125946.1 → NP_001119418.1 fibrillarin 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001119418.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9FEF8

Conserved Domains (1) summary

cl17173
Location:64 → 226

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...