PLE Microtubule associated protein (MAP65/ASE1) family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PLE
Official Full Name: Microtubule associated protein (MAP65/ASE1) family protein
Primary source: TAIR:AT5G51600
Locus tag: AT5G51600
See related: Araport:AT5G51600
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA MICROTUBULE-ASSOCIATED PROTEIN 65-3; ATMAP65-3; K17N15.15; K17N15_15; MAP65-3; MICROTUBULE-ASSOCIATED PROTEIN 65-3; PLEIADE
Summary: Mutant has defective roots. Essential for giant cell ontogenesis. Role in organizing the mitotic microtubule array during both early and late mitosis in all plant organs.
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Genomic context

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See PLE in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 12

Sequence:: Chromosome: 5; NC_003076.8 (20960779..20964537, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

POK2 likely stabilizes the phragmoplast midzone via interaction with the conserved microtubule-associated protein MAP65-3/PLEIADE, a well-established microtubule cross-linker.
Title: Dual localized kinesin-12 POK2 plays multiple roles during cell division and interacts with MAP65-3.
Cell cycle-regulated PLEIADE/AtMAP65-3 links membrane and microtubule dynamics during plant cytokinesis.
Title: Cell cycle-regulated PLEIADE/AtMAP65-3 links membrane and microtubule dynamics during plant cytokinesis.
downy mildew and powdery mildew stimulate AtMAP65-3 expression to down-regulate salicylic acid signaling for infection.
Title: The Arabidopsis microtubule-associated protein MAP65-3 supports infection by filamentous biotrophic pathogens by down-regulating salicylic acid-dependent defenses.
MAP65-3 selectively cross-linked interdigitating microtubules (IMTs) to allow antiparallel microtubules (MTs) to be closely engaged in the phragmoplast.
Title: Interaction of antiparallel microtubules in the phragmoplast is mediated by the microtubule-associated protein MAP65-3 in Arabidopsis.
Data conclude that MAP65-3 contains a distinct C-terminal MT binding site with a specific role in cross-linking antiparallel MTs toward their plus ends in the phragmoplast.
Title: Arabidopsis microtubule-associated protein MAP65-3 cross-links antiparallel microtubules toward their plus ends in the phragmoplast via its distinct C-terminal microtubule binding domain.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_124539.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cytokinesis by cell plate formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within formation of syncytium involving giant cell for nutrient acquisition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within microtubule polymerization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to nematode	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to nematode	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cortical microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	HDA more info	PubMed
located_in phragmoplast	HDA more info	PubMed
located_in phragmoplast	IDA Inferred from Direct Assay more info	PubMed
located_in preprophase band	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Microtubule associated protein (MAP65/ASE1) family protein

NP_199973.1

PLEIADE (PLE); CONTAINS InterPro DOMAIN/s: Microtubule-associated protein, MAP65/ASE1-type (InterPro:IPR007145); BEST Arabidopsis thaliana protein match is: microtubule-associated protein 65-4 (TAIR:AT3G60840.1); Has 4514 Blast hits to 3795 proteins in 427 species: Archae - 120; Bacteria - 292; Metazoa - 2464; Fungi - 290; Plants - 515; Viruses - 1; Other Eukaryotes - 832 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

20960779..20964537 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_124539.4 → NP_199973.1 Microtubule associated protein (MAP65/ASE1) family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_199973.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9FHM4

UniProtKB/TrEMBL

A0A178UES8, A0A5S9YD24, A0A654G9Z9

Conserved Domains (1) summary

pfam03999
Location:56 → 619

MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)