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FSD2 Fe superoxide dismutase 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 835183, updated on 18-Sep-2024

Summary

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Official Symbol
FSD2
Official Full Name
Fe superoxide dismutase 2
Primary source
TAIR:AT5G51100
Locus tag
AT5G51100
See related
Araport:AT5G51100
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
Fe superoxide dismutase 2; MWD22.4; MWD22_4
Summary
Fe superoxide dismutase whose mRNA levels are increased in response to exposure to UV-B.
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Genomic context

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See FSD2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
7
Sequence:
Chromosome: 5; NC_003076.8 (20773235..20775739, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Transcriptional coactivator/pterin dehydratase Neighboring gene ECA1 gametogenesis family protein (DUF1278) Neighboring gene polyadenylate-binding protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Plastid-Encoded RNA Polymerase-Associated Protein PAP9 Is a Superoxide Dismutase With Unusual Structural Features. Favier A, et al. Front Plant Sci, 2021. PMID 34276730, Free PMC Article
  2. LSU network hubs integrate abiotic and biotic stress responses via interaction with the superoxide dismutase FSD2. Garcia-Molina A, et al. J Exp Bot, 2017 Feb 1. PMID 28207043, Free PMC Article
  3. A heterocomplex of iron superoxide dismutases defends chloroplast nucleoids against oxidative stress and is essential for chloroplast development in Arabidopsis. Myouga F, et al. Plant Cell, 2008 Nov. PMID 18996978, Free PMC Article
  4. PRDA1, a novel chloroplast nucleoid protein, is required for early chloroplast development and is involved in the regulation of plastid gene expression in Arabidopsis. Qiao J, et al. Plant Cell Physiol, 2013 Dec. PMID 24132784
  5. Superoxide dismutase in Arabidopsis: an eclectic enzyme family with disparate regulation and protein localization. Kliebenstein DJ, et al. Plant Physiol, 1998 Oct. PMID 9765550, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LSU1 interacts with the chloroplastic superoxide dismutase FSD2 and stimulates its enzymatic activity in vivo and in vitro. Pseudomonas syringae virulence effectors interfere with this interaction and preclude re-localization of LSU1 to chloroplasts.
    Title: LSU network hubs integrate abiotic and biotic stress responses via interaction with the superoxide dismutase FSD2.
  2. FSD2 and FSD3 act as ROS scavengers in the maintenance of early chloroplast development by protecting the chloroplast nucleoids from ROS.
    Title: A heterocomplex of iron superoxide dismutases defends chloroplast nucleoids against oxidative stress and is essential for chloroplast development in Arabidopsis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001344920.1
NM_001344921.1
NM_124489.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables superoxide dismutase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables superoxide dismutase activity IEA
Inferred from Electronic Annotation
more info
  
enables superoxide dismutase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within response to UV IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast nucleoid HDA PubMed 
located_in chloroplast nucleoid IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of plastid-encoded plastid RNA polymerase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in thylakoid IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Fe superoxide dismutase 2
NP_199923.1
  • Fe superoxide dismutase 2 (FSD2); FUNCTIONS IN: superoxide dismutase activity; INVOLVED IN: response to UV; LOCATED IN: chloroplast, nucleoid; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Manganese/iron superoxide dismutase, N-terminal (InterPro:IPR019831), Manganese/iron superoxide dismutase (InterPro:IPR001189), Manganese/iron superoxide dismutase, C-terminal (InterPro:IPR019832), Manganese/iron superoxide dismutase, binding site (InterPro:IPR019833); BEST Arabidopsis thaliana protein match is: Fe superoxide dismutase 1 (TAIR:AT4G25100.5); Has 11522 Blast hits to 11521 proteins in 3361 species: Archae - 194; Bacteria - 8106; Metazoa - 433; Fungi - 799; Plants - 399; Viruses - 1; Other Eukaryotes - 1590 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    20773235..20775739 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001344919.1 → NP_001330687.1  Fe superoxide dismutase 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8BBM1

  2. NM_001344918.1 → NP_001330683.1  Fe superoxide dismutase 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8BBM1

  3. NM_001344917.1 → NP_001330684.1  Fe superoxide dismutase 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8BBK0

  4. NM_124489.3 → NP_199923.1  Fe superoxide dismutase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_199923.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O04879, Q9LU64
    UniProtKB/TrEMBL
    A0A178UQJ4
    Conserved Domains (3) summary
    PLN02685
    Location:5 → 305
    PLN02685; iron superoxide dismutase
    pfam00081
    Location:53 → 136
    Sod_Fe_N; Iron/manganese superoxide dismutases, alpha-hairpin domain
    pfam02777
    Location:144 → 262
    Sod_Fe_C; Iron/manganese superoxide dismutases, C-terminal domain

  5. NM_001344920.1 → NP_001330686.1  Fe superoxide dismutase 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UQJ4, A0A1P8BBJ5

  6. NM_001344921.1 → NP_001330685.1  Fe superoxide dismutase 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8BBK0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LU64.1

Gene LinkOut

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