HCT hydroxycinnamoyl-CoA shikimate/quinate hydroxycinnamoyl transferase [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: HCT
Official Full Name: hydroxycinnamoyl-CoA shikimate/quinate hydroxycinnamoyl transferase
Primary source: TAIR:AT5G48930
Locus tag: AT5G48930
See related: Araport:AT5G48930
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: hydroxycinnamoyl-CoA shikimate/quinate hydroxycinnamoyl transferase; K19E20.4; K19E20_4
Summary: At5g48930 has been shown to encode for the hydroxycinnamoyl-Coenzyme A shikimate/quinate hydroxycinnamoyltransferase (HCT) both synthesizing and catabolizing the hydroxycinnamoylesters (coumaroyl/caffeoyl shikimate and quinate) involved in the phenylpropanoid pathway. Influence on the accumulation of flavonoids which in turn inhibit auxin transport and reduce plant growth.
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Genomic context

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See HCT in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 2

Sequence:: Chromosome: 5; NC_003076.8 (19836299..19838235, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Findings indicate a structural basis for how dynamic conformational states of hydroxycinnamoyl-CoA:shikimate hydroxycinnamoyltransferase (HCT) favor native over non-native catalysis by reducing the number of futile encounters between the enzyme and shikimate.
Title: Dynamic Conformational States Dictate Selectivity toward the Native Substrate in a Substrate-Permissive Acyltransferase.
function of the acyltransferase in phenylpropanoid biosynthesis [hydroxycinnamoyl-coenzyme A shikimate/quinate hydroxycinnamoyltransferase [HCT]
Title: Silencing of hydroxycinnamoyl-coenzyme A shikimate/quinate hydroxycinnamoyltransferase affects phenylpropanoid biosynthesis.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_124270.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables quinate O-hydroxycinnamoyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables shikimate O-hydroxycinnamoyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within lignin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of flavonoid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: hydroxycinnamoyl-CoA shikimate/quinate hydroxycinnamoyl transferase

NP_199704.1

hydroxycinnamoyl-CoA shikimate/quinate hydroxycinnamoyl transferase (HCT); CONTAINS InterPro DOMAIN/s: Transferase (InterPro:IPR003480); BEST Arabidopsis thaliana protein match is: HXXXD-type acyl-transferase family protein (TAIR:AT5G57840.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

19836299..19838235 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_124270.4 → NP_199704.1 hydroxycinnamoyl-CoA shikimate/quinate hydroxycinnamoyl transferase [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_199704.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8LFT5, Q9FI78

UniProtKB/TrEMBL

A0A178UBG1

Conserved Domains (1) summary

PLN02663
Location:1 → 433

PLN02663; hydroxycinnamoyl-CoA:shikimate/quinate hydroxycinnamoyltransferase