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GFA2 gametophytic factor 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 834854, updated on 18-Sep-2024

Summary

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Official Symbol
GFA2
Official Full Name
gametophytic factor 2
Primary source
TAIR:AT5G48030
Locus tag
AT5G48030
See related
Araport:AT5G48030
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
gametophytic factor 2; MDN11.11; MDN11_11
Summary
encodes a mitochondrially targeted DNAJ protein involved in female gametophyte development.
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Genomic context

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See GFA2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
18
Sequence:
Chromosome: 5; NC_003076.8 (19465788..19469939, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene thalianol synthase 1 Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein Neighboring gene Ubiquitin carboxyl-terminal hydrolase family protein Neighboring gene Copia-like polyprotein/retrotransposon

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of gametophytic mutations affecting female gametophyte development in Arabidopsis. Christensen CA, et al. Dev Biol, 1998 Oct 1. PMID 9758709
  2. The molecular chaperone mtHSC70-1 interacts with DjA30 to regulate female gametophyte development and fertility in Arabidopsis. Zhai X, et al. Plant J, 2023 Sep. PMID 37294615
  3. Mitochondrial GFA2 is required for synergid cell death in Arabidopsis. Christensen CA, et al. Plant Cell, 2002 Sep. PMID 12215516, Free PMC Article
  4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_124177.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables heat shock protein binding IEA
Inferred from Electronic Annotation
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chaperone cofactor-dependent protein refolding IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within embryo sac cellularization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryo sac development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nuclear membrane fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within polar nucleus fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to heat IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within synergid death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
gametophytic factor 2
NP_568690.1
  • gametophytic factor 2 (GFA2); FUNCTIONS IN: unfolded protein binding, heat shock protein binding; INVOLVED IN: in 7 processes; LOCATED IN: mitochondrion; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Molecular chaperone, heat shock protein, Hsp40, DnaJ (InterPro:IPR015609), HSP40/DnaJ peptide-binding (InterPro:IPR008971), Chaperone DnaJ, C-terminal (InterPro:IPR002939), Heat shock protein DnaJ, N-terminal (InterPro:IPR001623), Heat shock protein DnaJ, conserved site (InterPro:IPR018253), Heat shock protein DnaJ, cysteine-rich domain (InterPro:IPR001305), Heat shock protein DnaJ (InterPro:IPR003095); BEST Arabidopsis thaliana protein match is: DNAJ heat shock family protein (TAIR:AT1G28210.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    19465788..19469939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_124177.4 → NP_568690.1  gametophytic factor 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_568690.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8GWW8, Q8L8A1, Q8LEU4, Q9FI35
    UniProtKB/TrEMBL
    A0A178UJR3, A0A5S9YC12, A0A654GA03
    Conserved Domains (1) summary
    COG0484
    Location:90 → 450
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8GWW8.1

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