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FRA1 P-loop containing nucleoside triphosphate hydrolases superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 834833, updated on 18-Sep-2024

Summary

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Official Symbol
FRA1
Official Full Name
P-loop containing nucleoside triphosphate hydrolases superfamily protein
Primary source
TAIR:AT5G47820
Locus tag
AT5G47820
See related
Araport:AT5G47820
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
FRAGILE FIBER 1; MCA23.16; MCA23_16
Summary
encodes a kinesin-like protein with an N-terminal microtubule binding motor domain. Protein is localized to the periphery of the cytoplasm and mutants in the gene exhibit altered orientation of cellulose microfibrils and reduced mechanical strength of fibers.
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Genomic context

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See FRA1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
23
Sequence:
Chromosome: 5; NC_003076.8 (19366133..19372815)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene miscRNA Neighboring gene uncharacterized protein Neighboring gene adenosine monophosphate kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Arabidopsis kinesin-4, FRA1, requires a high level of processive motility to function correctly. Ganguly A, et al. J Cell Sci, 2017 Apr 1. PMID 28219953
  2. The fragile Fiber1 kinesin contributes to cortical microtubule-mediated trafficking of cell wall components. Zhu C, et al. Plant Physiol, 2015 Mar. PMID 25646318, Free PMC Article
  3. Single molecule analysis of the Arabidopsis FRA1 kinesin shows that it is a functional motor protein with unusually high processivity. Zhu C, et al. Mol Plant, 2011 Sep. PMID 21914648
  4. A kinesin-like protein is essential for oriented deposition of cellulose microfibrils and cell wall strength. Zhong R, et al. Plant Cell, 2002 Dec. PMID 12468730, Free PMC Article
  5. Kinesin-4 Functions in Vesicular Transport on Cortical Microtubules and Regulates Cell Wall Mechanics during Cell Elongation in Plants. Kong Z, et al. Mol Plant, 2015 Jul. PMID 25600279

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FRA1 Kinesin Modulates the Lateral Stability of Cortical Microtubules through Cellulose Synthase-Microtubule Uncoupling Proteins.
    Title: FRA1 Kinesin Modulates the Lateral Stability of Cortical Microtubules through Cellulose Synthase-Microtubule Uncoupling Proteins.
  2. a high density of processive motility is necessary for the physiological function of FRA1.
    Title: The Arabidopsis kinesin-4, FRA1, requires a high level of processive motility to function correctly.
  3. FRA1 contributes to cell wall production by transporting Golgi-derived vesicles along cortical microtubules for secretion.
    Title: The fragile Fiber1 kinesin contributes to cortical microtubule-mediated trafficking of cell wall components.
  4. FRA1 is a functional motor protein to drive long-distance transport of cargo along cortical microtubules.
    Title: Single molecule analysis of the Arabidopsis FRA1 kinesin shows that it is a functional motor protein with unusually high processivity.
Submit: New GeneRIF Correction

General gene information

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Homology

NM_124156.5
NM_180820.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule motor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables plus-end-directed microtubule motor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellulose microfibril organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoskeleton-dependent intracellular transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within plant-type cell wall biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cortical microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
P-loop containing nucleoside triphosphate hydrolases superfamily protein
NP_199593.2
  • FRAGILE FIBER 1 (FRA1); CONTAINS InterPro DOMAIN/s: Kinesin, motor region, conserved site (InterPro:IPR019821), Kinesin, motor domain (InterPro:IPR001752); BEST Arabidopsis thaliana protein match is: ATP binding microtubule motor family protein (TAIR:AT3G50240.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_851151.1
  • FRAGILE FIBER 1 (FRA1); CONTAINS InterPro DOMAIN/s: Kinesin, motor region, conserved site (InterPro:IPR019821), Kinesin, motor domain (InterPro:IPR001752); BEST Arabidopsis thaliana protein match is: ATP binding microtubule motor family protein (TAIR:AT3G50240.1); Has 53631 Blast hits to 37823 proteins in 1811 species: Archae - 386; Bacteria - 4938; Metazoa - 26865; Fungi - 4658; Plants - 3439; Viruses - 113; Other Eukaryotes - 13232 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    19366133..19372815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_180820.2 → NP_851151.1  P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_851151.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8GS71, Q9FIJ9
    UniProtKB/TrEMBL
    A0A178UKL3, A0A5S9YC94, A0A654G9H8
    Conserved Domains (2) summary
    COG0419
    Location:490 → 912
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01372
    Location:10 → 371
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

  2. NM_124156.5 → NP_199593.2  P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_199593.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8GS71, Q9FIJ9
    UniProtKB/TrEMBL
    A0A178UKL3, A0A5S9YC94, A0A654G9H8
    Conserved Domains (2) summary
    COG0419
    Location:490 → 912
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01372
    Location:10 → 371
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8GS71.1

Gene LinkOut

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