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NUDT2 nudix hydrolase homolog 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 834816, updated on 18-Sep-2024

Summary

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Official Symbol
NUDT2
Official Full Name
nudix hydrolase homolog 2
Primary source
TAIR:AT5G47650
Locus tag
AT5G47650
See related
Araport:AT5G47650
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS THALIANA NUDIX HYDROLASE HOMOLOG 2; ATNUDT2; ATNUDX2; MNJ7.24; MNJ7_24; nudix hydrolase homolog 2
Summary
Encodes an ADP-ribose pyrophosphatase that confers enhanced tolerance to oxidative stress.
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Genomic context

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See NUDT2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
9
Sequence:
Chromosome: 5; NC_003076.8 (19310192..19312747, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene mitochondrial acyl carrier protein 3 Neighboring gene Pollen Ole e 1 allergen and extensin family protein Neighboring gene ncRNA Neighboring gene nuclear factor Y, subunit B2 Neighboring gene Homeodomain-like superfamily protein Neighboring gene nuclear factor Y, subunit B6 Neighboring gene tRNA (guanine(9)-N1)-methyltransferase-like protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overexpression of an ADP-ribose pyrophosphatase, AtNUDX2, confers enhanced tolerance to oxidative stress in Arabidopsis plants. Ogawa T, et al. Plant J, 2009 Jan. PMID 18798872
  2. Comprehensive analysis of cytosolic Nudix hydrolases in Arabidopsis thaliana. Ogawa T, et al. J Biol Chem, 2005 Jul 1. PMID 15878881
  3. A mesoscale abscisic acid hormone interactome reveals a dynamic signaling landscape in Arabidopsis. Lumba S, et al. Dev Cell, 2014 May 12. PMID 24823379
  4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001344736.1
NM_001344737.1
NM_001344738.1
NM_001344739.1
NM_124139.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ADP-ribose diphosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NAD binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables NAD+ diphosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables NADH pyrophosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytosol ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
nudix hydrolase homolog 2
NP_568687.1
  • nudix hydrolase homolog 2 (NUDT2); FUNCTIONS IN: hydrolase activity, ADP-ribose diphosphatase activity, NAD or NADH binding; INVOLVED IN: response to oxidative stress; LOCATED IN: cytosol; EXPRESSED IN: 17 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: NUDIX hydrolase domain-like (InterPro:IPR015797), Nudix hydrolase 6-like (InterPro:IPR003293), NUDIX hydrolase domain (InterPro:IPR000086); BEST Arabidopsis thaliana protein match is: nudix hydrolase homolog 10 (TAIR:AT4G25434.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    19310192..19312747 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_124139.4 → NP_568687.1  nudix hydrolase homolog 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_568687.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94B74, Q9FGJ2
    UniProtKB/TrEMBL
    A0A7G2FKW1
    Conserved Domains (1) summary
    cd04670
    Location:111 → 242
    Nudix_Hydrolase_12; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

  2. NM_001344737.1 → NP_001331652.1  nudix hydrolase homolog 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94B74, Q9FGJ2
    UniProtKB/TrEMBL
    A0A7G2FKW1

  3. NM_001344736.1 → NP_001331651.1  nudix hydrolase homolog 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8BEH7, A0A5S9YBZ9

  4. NM_001344738.1 → NP_001331649.1  nudix hydrolase homolog 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8BEL5, A0A5S9YBZ9

  5. NM_001344739.1 → NP_001331650.1  nudix hydrolase homolog 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94B74, Q9FGJ2
    UniProtKB/TrEMBL
    A0A7G2FKW1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q94B74.1

Gene LinkOut

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