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MAP18 microtubule-associated protein 18 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 834489, updated on 18-Sep-2024

Summary

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Official Symbol
MAP18
Official Full Name
microtubule-associated protein 18
Primary source
TAIR:AT5G44610
Locus tag
AT5G44610
See related
Araport:AT5G44610
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
K15C23.5; K15C23_5; microtubule-associated protein 18; PCAP2; PLASMA MEMBRANE ASSOCIATED CA2+-BINDING PROTEIN-2
Summary
Encodes a protein with seven repeated VEEKK motifs. RNAi and overexpression experiments suggest that the gene is not involved in cell division but might be consequential for cell shape of epidermal and cortical cells. The protein encoded by this gene binds to cortical microtubules and inhibits tubulin polymerization. Associates to the plasma membrane and interacts with calmodulin and phosphatidylinositol phosphates, indicating an involvement in cellular signal transduction. Expression is enhanced by abiotic and hormonal factors. Induced during senescence.
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Genomic context

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See MAP18 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
3
Sequence:
Chromosome: 5; NC_003076.8 (17993535..17994722, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene cytochrome P450, family 706, subfamily A, polypeptide 3 Neighboring gene Terpenoid cyclases/Protein prenyltransferases superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Arabidopsis PCaP2 modulates the phosphatidylinositol 4,5-bisphosphate signal on the plasma membrane and attenuates root hair elongation. Kato M, et al. Plant J, 2019 Aug. PMID 30604455
  2. PCaP2 regulates nuclear positioning in growing Arabidopsis thaliana root hairs by modulating filamentous actin organization. Zhang Y, et al. Plant Cell Rep, 2015 Aug. PMID 25929794
  3. MAP18 regulates the direction of pollen tube growth in Arabidopsis by modulating F-actin organization. Zhu L, et al. Plant Cell, 2013 Mar. PMID 23463774, Free PMC Article
  4. The Ca(2+) -binding protein PCaP2 located on the plasma membrane is involved in root hair development as a possible signal transducer. Kato M, et al. Plant J, 2013 May. PMID 23445487
  5. Leaf senescence is accompanied by an early disruption of the microtubule network in Arabidopsis. Keech O, et al. Plant Physiol, 2010 Dec. PMID 20966154, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results indicate a function of MICROTUBULE-ASSOCIATED PROTEIN18 (MAP18) in the regulation of Rop GTPase ROP2 (ROP2) activation during root hair growth.
    Title: The Microtubule-Associated Protein MAP18 Affects ROP2 GTPase Activity during Root Hair Growth.
  2. maintains nucleus at fixed distance from the apex during root hair growth by modulating actin filaments
    Title: PCaP2 regulates nuclear positioning in growing Arabidopsis thaliana root hairs by modulating filamentous actin organization.
  3. MAP18 is required for normal pollen tube growth in vitro.
    Title: MAP18 regulates the direction of pollen tube growth in Arabidopsis by modulating F-actin organization.
  4. The N23 domain of PCaP2 negatively regulates root hair tip growth via processing Ca(2+) and phosphatidylinositol phosphates (PtdInsPs) signals on the plasma membrane, while the residual domain is involved in the polarization of cell expansion.
    Title: The Ca(2+) -binding protein PCaP2 located on the plasma membrane is involved in root hair development as a possible signal transducer.
  5. PCaP2 is involved in intracellular signaling through interaction with PtdInsPs and calmodulin in growing root hairs. [PCaP2]
    Title: An Arabidopsis hydrophilic Ca2(+) -binding protein with a PEVK-rich domain, PCaP2, is associated with the plasma membrane and interacts with calmodulin and phosphatidylinositol phosphates.
  6. MAP18 may play a role in regulating directional cell growth and cortical microtubule organization by destabilizing microtubules.[MAP18]
    Title: Arabidopsis MICROTUBULE-ASSOCIATED PROTEIN18 functions in directional cell growth by destabilizing cortical microtubules.
Submit: New GeneRIF Correction

General gene information

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NM_001344568.1
NM_001344569.1
NM_123828.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables 1-phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables signaling receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
NOT involved_in cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cortical microtubule organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within leaf senescence IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within negative regulation of microtubule polymerization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to abscisic acid IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to arsenic-containing substance IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to cold IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to gibberellin IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to metal ion IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to salt stress IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within root hair cell tip growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
colocalizes_with cortical microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in pollen tube IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
microtubule-associated protein 18
NP_568636.1
  • microtubule-associated protein 18 (MAP18); FUNCTIONS IN: microtubule binding, calmodulin binding, phosphatidylinositol binding; INVOLVED IN: in 9 processes; LOCATED IN: cortical microtubule, plasma membrane; EXPRESSED IN: 12 plant structures; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, 4 anthesis; CONTAINS InterPro DOMAIN/s: DREPP plasma membrane polypeptide (InterPro:IPR008469); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    17993535..17994722 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_123828.4 → NP_568636.1  microtubule-associated protein 18 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_568636.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C0Z2P4, Q9LU05
    UniProtKB/TrEMBL
    A0A178UQA7, A0A5S9YB01

  2. NM_001344568.1 → NP_001331522.1  microtubule-associated protein 18 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C0Z2P4, Q9LU05
    UniProtKB/TrEMBL
    A0A178UQA7, A0A5S9YB01

  3. NM_001344569.1 → NP_001331521.1  microtubule-associated protein 18 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C0Z2P4, Q9LU05
    UniProtKB/TrEMBL
    A0A178UQA7, A0A5S9YB01
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LU05.1

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