U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CBP20 CAP-binding protein 20 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 834443, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
CBP20
Official Full Name
CAP-binding protein 20
Primary source
TAIR:AT5G44200
Locus tag
AT5G44200
See related
Araport:AT5G44200
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATCBP20; CAP-binding protein 20; MLN1.12; MLN1_12
Summary
Encodes a nuclear cap-binding protein that forms a heterodimeric complex with ABH1 (ATCBP80) and is likely to participate in RNA metabolism. Its mRNA is ubiquitously expressed.Loss of function mutations suggest a role in processing of pri-miRNA and mRNA splicing.
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CBP20 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
9
Sequence:
Chromosome: 5; NC_003076.8 (17801737..17804203, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Homeodomain-like transcriptional regulator Neighboring gene GOLDEN2-like 2 Neighboring gene erf domain protein 9 Neighboring gene F-box family protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. New phenotypes of the drought-tolerant cbp20 Arabidopsis thaliana mutant have changed epidermal morphology. Jäger K, et al. Plant Biol (Stuttg), 2011 Jan. PMID 21143728
  2. Cloning and characterization of two subunits of Arabidopsis thaliana nuclear cap-binding complex. Kmieciak M, et al. Gene, 2002 Jan 23. PMID 11867224
  3. Quantitative proteomics analysis reveals that the nuclear cap-binding complex proteins arabidopsis CBP20 and CBP80 modulate the salt stress response. Kong X, et al. J Proteome Res, 2014 May 2. PMID 24689873
  4. Involvement of the nuclear cap-binding protein complex in alternative splicing in Arabidopsis thaliana. Raczynska KD, et al. Nucleic Acids Res, 2010 Jan. PMID 19864257, Free PMC Article
  5. Selective recruitment of proteins to 5' cap complexes during the growth cycle in Arabidopsis. Bush MS, et al. Plant J, 2009 Aug. PMID 19453450

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we proposed that ethylene regulated phosphorylation of CBP20 is involved in the root growth and one pathway is through the regulation of miR319b and its target MYB33 in roots
    Title: Phosphorylation of CBP20 Links MicroRNA to Root Growth in the Ethylene Response.
  2. Data suggest that CBP20 and CBP80 (ABH1) have synergistic roles during the salt stress response.
    Title: Quantitative proteomics analysis reveals that the nuclear cap-binding complex proteins arabidopsis CBP20 and CBP80 modulate the salt stress response.
  3. SERRATE, CAP BINDING PROTEIN20 (CBP20), and CBP80 are regulators of lincRNA expression and biogenesis. RT-PCR experiments confirmed these three proteins are also needed for splicing of a small group of intron-containing lincRNAs.
    Title: Genome-wide analysis uncovers regulation of long intergenic noncoding RNAs in Arabidopsis.
  4. Some hitherto undescribed changes were found in the tissue structure and epidermal morphology of cbp20 mutant
    Title: New phenotypes of the drought-tolerant cbp20 Arabidopsis thaliana mutant have changed epidermal morphology.
  5. The cbp80(abh1) and cbp20/80 mutants had many more changes in alternative splicing in common than did cbp20 and cbp20/80 suggesting that CBP80 plays a more significant role in alternative splicing than CBP20.
    Title: Involvement of the nuclear cap-binding protein complex in alternative splicing in Arabidopsis thaliana.
  6. The N-terminal part of AtCBP20 is crucial for the formation of a complex with AtCBP80.
    Title: The Arabidopsis CBP20 targets the cap-binding complex to the nucleus, and is stabilized by CBP80.
  7. CBP20 and CBP80 function in miRNA biogenesis by binding to pri-miRNA transcripts, and are stabilized by ABA by a post-translational mechanism.
    Title: Two cap-binding proteins CBP20 and CBP80 are involved in processing primary MicroRNAs.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help
NM_001085236.2
NM_123787.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables RNA cap binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA metabolic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within RNA splicing, via endonucleolytic cleavage and ligation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within defense response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA cis splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within primary miRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

Go to the top of the page Help
Preferred Names
CAP-binding protein 20
NP_001078705.1
  • CAP-binding protein 20 (CBP20); FUNCTIONS IN: RNA binding, RNA cap binding; INVOLVED IN: RNA metabolic process, RNA splicing, via endonucleolytic cleavage and ligation, primary microRNA processing; LOCATED IN: mRNA cap binding complex; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: RNA-binding (RRM/RBD/RNP motifs) family protein (TAIR:AT3G46020.1); Has 9575 Blast hits to 9549 proteins in 2190 species: Archae - 96; Bacteria - 7682; Metazoa - 239; Fungi - 361; Plants - 280; Viruses - 2; Other Eukaryotes - 915 (source: NCBI BLink).
NP_199233.1
  • CAP-binding protein 20 (CBP20); FUNCTIONS IN: RNA binding, RNA cap binding; INVOLVED IN: RNA metabolic process, RNA splicing, via endonucleolytic cleavage and ligation, primary microRNA processing; LOCATED IN: mRNA cap binding complex; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: RNA-binding (RRM/RBD/RNP motifs) family protein (TAIR:AT3G46020.1); Has 1672 Blast hits to 1670 proteins in 70 species: Archae - 0; Bacteria - 6; Metazoa - 7; Fungi - 2; Plants - 1623; Viruses - 0; Other Eukaryotes - 34 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    17801737..17804203 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001085236.2 → NP_001078705.1  CAP-binding protein 20 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001078705.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XFD1
    UniProtKB/TrEMBL
    A0A178UGA0
    Conserved Domains (2) summary
    COG0724
    Location:33 → 118
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12240
    Location:36 → 113
    RRM_NCBP2; RNA recognition motif found in nuclear cap-binding protein subunit 2 (CBP20) and similar proteins

  2. NM_123787.4 → NP_199233.1  CAP-binding protein 20 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_199233.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XFD1
    UniProtKB/TrEMBL
    A0A178UGA0
    Conserved Domains (2) summary
    COG0724
    Location:33 → 118
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12240
    Location:36 → 113
    RRM_NCBP2; RNA recognition motif found in nuclear cap-binding protein subunit 2 (CBP20) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XFD1.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools